Pleuropulmonary Zygomycosis in a Diabetic Child

Devidayal,; Menon, Prema; Vaiphei, Kim; Singh, Meenu; Rao, K Janardhana; Singhi, Sunit

doi:10.1297/cpe.18.35

Cited by 3 publications

(5 citation statements)

References 15 publications

(22 reference statements)

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“… a & b: CECT chest showing cavitatory pneumonia on right side. ); 1 patient, described elsewhere, showed empyema in addition ( 10 ). Another patient had necrotic thick walled abscess in the thymus with consolidation of apical segment of right upper lobe and small subpleural nodular lesions in the right lower lobe ( 11 ).…”

Section: Resultsmentioning

confidence: 93%

“…In patients suspected to have rhinocerebral involvement, smear examination of scrapings from nasal or sinus cavity are useful aid to rapid diagnosis. The diagnosis of pulmonary IFI is highly probable if the CT scan shows cavitary pneumonia in a child with minimal pulmonary symptoms and previously described risk factors ( 10 ). Fine needle aspiration cytology can be very useful in reaching an early diagnosis of pulmonary IFIs as compared to more invasive transbronchial biopsy ( 10 , 18 ).…”

Section: Discussionmentioning

confidence: 98%

“…Poor compliance to therapy as evidenced by poor clinic attendance, risk taking behaviors and recurrent admissions for DKA has been documented to increase susceptibility to IFIs ( 12 ). Similarly malnourished state resulting either from a poor glycemic control or poor dietary management predispose diabetic children to IFIs ( 3 , 10 , 11 , 12 ). The presence of critical predisposing factors and an unusually high occurrence of IFIs in our patients is probably a result of the prevailing healthcare situation related to the management of T1D in children in our setup ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Dayal

Jain

Kumar

et al. 2015

Clin Pediatr Endocrinol

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There is scarcity of data on spectrum and outcome of invasive filamentous fungal infections (IFIs) in children with Type 1 diabetes (T1D) from developing countries. A retrospective review of medical records of children with T1D hospitalized with IFI over the past decade at the Pediatric Endocrinology and Diabetes Unit of a large tertiary care hospital of North India was performed with an aim to study their clinical spectrum, hospital course and final outcome. Of the 10 patients studied, nasal/paranasal involvement was seen in 6 and pulmonary involvement in 5 patients. One patient developed disseminated disease. Majority of the identified mycoses belonged to Class Zygomycetes Order Mucorales. Early surgery along with antifungal therapy helped limit the extension of infection and achieve a good outcome in majority of patients. Two patients died; one with a late diagnosis of pulmonary mucormycosis and the other with disseminated disease. The longterm morbidity in the survivors was minimal. In conclusion, rapid diagnosis followed by a multimodal approach involving aggressive surgical debridement, appropriate antifungal therapy and control of hyperglycemic state is the key to good outcome in this otherwise lethal infection.

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Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Dayal

Jain

Kumar

et al. 2015

Clin Pediatr Endocrinol

Self Cite

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“…1 The most common forms are rhinocerebral, pulmonary, cutaneous, digestive, or disseminated infections, although any organ system may be involved. [2][3][4] The outcome largely depends on a multimodal approach that often involves extensive surgical removal of the affected tissues along with the use of antifungals and effective control of the underlying condition. [5][6][7] Mucormycosis has presented new global challenges in the last few decades.…”

Section: Introductionmentioning

confidence: 99%

Global Mucormycosis Research: A Bibliometric Assessment Based on Scopus Database (1998-2021)

Gupta¹,

Mamdapur²,

Gupta³

et al. 2021

JYP

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Background:Mucormycosis is an invasive filamentous fungal infection that usually occurs in immunocompromised individuals. Although the disease is well-researched, the assessment of global research on mucormycosis is scarcely reported. Materials and Methods: We used Elsevier's Scopus database to retrieve mucormycosis publications from 1998 to 2021. Using various bibliometric tools, the publication data were analyzed with regard to the growth in the number of publications, their citations, top-yielding organizations and authors, collaborations, and productive journals. Results: One hundred twenty countries contributed 5658 publications to research on mucormycosis. The USA leads with a 30.6% share, followed by India (14.1%), France, Germany, and Spain (5.4% to 5.8%). The annual and absolute growth was 3.9% and 82.6%; only 11.2% of publications were funded. The average citations per paper decreased from 28.4 to 11.4 during the two 12-yr periods. The research involved 931 organizations and 1123 authors. The leading organizations were the

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“…1,2 The infection may involve any organ system in the body, but rhinocerebral, pulmonary, cutaneous, and gastrointestinal forms are the most common. [2][3][4][5] The infection may sometimes involve multiple organs even though the spread usually occurs in a contiguous manner. 2 The prognosis for survival is generally poor, and the outcome depends on an aggressive management strategy involving extensive surgical resection of the affected tissues, the use of antifungal drugs, and control of the underlying condition.…”

Section: Introductionmentioning

confidence: 99%

Black Fungus (Mucormycosis) Research in India during 1998-2021: A Scopus-based Scientometric Analysis

Gupta¹,

Mamdapur²,

Dayal³

2021

IJMEDPH

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Introduction: Mucormycosis is a well-researched infection worldwide. The Indian contribution to global Mucormycosis research remains unevaluated. Materials and Methods: Elsevier's Scopus database was used to retrieve Indian publications on mucormycosis during 1998-2021. The extracted data were analyzed in terms of the number of publications, citation metrics, top productive organizations and authors, research collaborations, and active journals, using appropriate bibliometric tools. Results: India produced 799 publications on mucormycosis during 1998-2021. The publications grew at 8.5% annually and 175.1% cumulatively and received on average 9.6 citations per paper (CPP). Only 8.7% of publications involved international collaboration. The most researched types of mucormycosis were pulmonary and gastrointestinal, while diabetes mellitus and diabetic ketoacidosis were the top risk factors studied. Most of the research focused on clinical studies and treatment, while genetics was the least researched aspect of mucormycosis. The top 20 of the 294 organizations and 384 authors that participated in research contributed 59.7% and 29.4% to the total national output, and 97.3% and 76.2% to total citations, respectively. The most productive organizations were PGIMER-Chandigarh, AIIMS-New Delhi, and CMC-Vellore, and the most prolific authors were A. Chakrabarti, M.R. Shivprakash, and J. Chander. Indian Journal of Otolaryngology and Head and Neck Surgery, Mycosis, and BMJ Case Reports were the high-yielding journals, whereas Medical Mycology, Mycosis, and Journal of Postgraduate Medicine were the most impactful. Conclusion: Indian research in mucormycosis has shown consistent growth during 1998-2021. There is, however, a need to improve on collaborative research and focus on emerging areas such as the genetics of mucormycosis.

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Pleuropulmonary Zygomycosis in a Diabetic Child

Cited by 3 publications

References 15 publications

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Global Mucormycosis Research: A Bibliometric Assessment Based on Scopus Database (1998-2021)

Black Fungus (Mucormycosis) Research in India during 1998-2021: A Scopus-based Scientometric Analysis

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