Pleurodesis using different agents in malignant pleural effusion

Bakr, Ramadan; El-Mahalawy, Ibrahim I.; Abdelaal, Gehan A.; Mabrouk, Ali A.; Ali, A. A.

doi:10.1016/j.ejcdt.2012.07.005

Cited by 16 publications

(15 citation statements)

References 12 publications

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“…During the last few years, the recently developed LENT score has allowed surgeons to stratify and predict survival/mortality; indirectly allowing better patient selection determining who will most likely fail pleurodesis with increased peri-operative mortality. 19 , 20 A low-risk LENT score (0-1) indicates a 319 days life expectancy increasing the candidacy for pleurodesis. A moderate LENT score (2-4) predicts an overall life expectancy of 130 days reducing the chances of benefitting from pleurodesis, a high LENT score (5-7) indicates a life expectancy of 44 days making patients poor candidates for pleurodesis because of high perioperative mortality.…”

Section: Discussionmentioning

confidence: 99%

“…A moderate LENT score (2-4) predicts an overall life expectancy of 130 days reducing the chances of benefitting from pleurodesis, a high LENT score (5-7) indicates a life expectancy of 44 days making patients poor candidates for pleurodesis because of high perioperative mortality. 19 , 20 Due to its recent introduction, the LENT score system has not yet been implemented as a standard in Latin America. Despite high-mortality and low-survival for high-risk LENT score patients, in this study, most patients 44 (97.7%) had moderate to high-risk LENT scores along with a 93.3% successful pleurodesis and improved respiratory function and symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Video-assisted thoracoscopic iodopovidone pleurodesis for malignant pleural effusions in moderate to high-risk Colombian patients

Garzón

Vinck

Cárdenas

et al. 2020

J Cardiovasc Thorac Res

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Introduction: In developing countries where talc may not be readily available, video-assisted thoracoscopic (VATS) iodopovidone pleurodesis offers an excellent alternative for the treatment of malignant pleural effusions (MPEs). Methods: This study analyzes a retrospective experience using VATS iodopovidone pleurodesis for malignant pleural effusions at a single cardiothoracic center in the capital of Colombia evaluating success according to LENT (Lactate, Eastern Cooperative Oncology Group-ECOG, Neutrophil-Lymphocyte ratio, Tumor type) scores. A total of 75 records of patients taken to VATS iodopovidone pleurodesis for MPEs were retrieved from our institutional database during a 5-year period from 2014-2019. Of these, 45 had complete clinical history data necessary to analyze both LENT scores and post-op follow-up imaging. Results: Of the 45 patients evaluated, 93.3% (42 patients) had either complete resolution of pleural effusions or partial resolution with an asymptomatic recovery within the first month post op. Chest pain was the most common postoperative complaint, which was present in 20% of patients. The mean postoperative ECOG score was 2±1.7. Patients with moderate to high-risk LENT scores had success rates of 96.7% and 92.3% respectively. Conclusion: Video-assisted thoracoscopic pleurodesis using Iodopovidone-iodine is an effective approach for MPEs. In developing countries where Iodopovidone iodine is readily available and affordable, patients may benefit from this agent with excellent results and minimal complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Video-assisted thoracoscopic iodopovidone pleurodesis for malignant pleural effusions in moderate to high-risk Colombian patients

Garzón

Vinck

Cárdenas

et al. 2020

J Cardiovasc Thorac Res

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“…Chest drain was left clamped and the patient's position rotated for 1 h after which the clamp was released and fluid allowed to drain out without negative suction application. [ 2 ] Chest drain was removed on the 14 th postoperative day [ Figure 3 ]. He was discharged on the 15 th postoperative day.…”

Section: Case Reportmentioning

confidence: 99%

Chylothorax after off-pump coronary artery bypass graft surgery: Management strategy

Waikar¹,

Kamalaneson²,

Zamri³

et al. 2018

Ann Card Anaesth

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Chylothorax is a rare complication after cardiac surgery but is associated with morbidity and mortality. The most common cause of chylothorax is damage to or avulsion of thoracic duct by electrocautery during left internal thoracic artery harvesting for coronary artery bypass graft (CABG) surgery. We describe a case of chylothorax after off-pump CABG, which was successfully treated with thoracostomy tube drainage, withholding of oral intake, total parenteral nutrition and subcutaneous octreotide, a somatostatin analog, and chemical pleurodesis.

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“…Pleurodesis is the obliteration of the pleural space by fusion of the visceral and parietal pleurae with fibrous tissue. [ 6 ] It is suggested that chemical agents used for the procedure, locally activates the coagulation system and production of fibrogenic cytokines and consequently production of collagen. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

“…), antibiotics (tetracyclines, minocycline, doxycycline), silver nitrate (SN), immunomodulating and biological agents have been investigated and different results have been achieved. [ 6 8 9 10 ] It seems that the ideal pleural sclerosing agent for each setting should be selected according to the characteristics of the patients and facilities of the center.…”

Section: Introductionmentioning

confidence: 99%

Silver nitrate versus tetracycline in pleurodesis for malignant pleural effusions; a prospective randomized trial

2015

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Pleurodesis using different agents in malignant pleural effusion

Cited by 16 publications

References 12 publications

Video-assisted thoracoscopic iodopovidone pleurodesis for malignant pleural effusions in moderate to high-risk Colombian patients

Video-assisted thoracoscopic iodopovidone pleurodesis for malignant pleural effusions in moderate to high-risk Colombian patients

Chylothorax after off-pump coronary artery bypass graft surgery: Management strategy

Silver nitrate versus tetracycline in pleurodesis for malignant pleural effusions; a prospective randomized trial

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