Pleurodesis

Lamb, Carla; Li, Andrew; Thakkar, Dhaval; Lee, Pyng

doi:10.1055/s-0039-1693997

Cited by 15 publications

(9 citation statements)

References 99 publications

(152 reference statements)

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“…Differences in the efficacy of pleurodesis between silver nitrate and talc could partially explain the observed discrepancy in the results observed between 7 and 28 days in the two pleurodesis agent groups in the study by Teixeira and colleagues 45 . Silver nitrate has been associated with better efficacy (96% vs 84%) in achieving pleurodesis, while it has also been used as a backup agent after talc failure 68‐70 …”

Section: Discussionmentioning

confidence: 99%

The anti‐adhesive effect of anti‐VEGF agents in experimental models: A systematic review

Giannis

Geropoulos

Ziogas

et al. 2020

Wound Repair Regeneration

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Adhesions constitute a major problem in abdominal‐pelvic and thoracic surgery with significant impact in the postoperative quality of life and healthcare services utilization. Adhesiogenesis is the result of increased fibrin formation, impaired fibrinolysis, angiogenesis, and fibrosis. Despite the recent advancements, the ideal anti‐adhesive agent remains to be determined. To this end, we performed a comprehensive literature search in PubMed, EMBASE, and Scopus databases to identify studies investigating the antiadhesive role of anti‐VEGF agents in peritoneal, pleural, and pericardial experimental adhesion models. Fifteen studies were eligible for inclusion with a total population of 602 animals (334 rats, 180 rabbits, and 88 mice). The majority of included studies (11/15) used bevacizumab, while three studies used other anti‐VEGF antibodies and one study used an anti‐VEGFR‐antibody. A rat model was used in nine studies, while rabbit (n = 3) or mouse (n = 3) models were used less frequently. Eleven studies used peritoneal models, three studies used pleural models, and one study used a pericardial model. The scales (n = 12) and interval (Range: 1‐42 days) used for the evaluation of adhesions varied between the studies. All studies demonstrated a significant decrease in adhesion scores between the anti‐VEGF and control groups up to 42 days postprocedure. VEGF blockade resulted in decreased fibrosis in four out of five studies that used peritoneal models, while the effect on pleural models depended on the pleurodesis agent and was significant between 7 and 28 days. The effect of anti‐VEGF agents on anastomosis integrity depends on the dose and the model that is used (inconclusive results).Current data support the anti‐adhesive role of Anti‐VEGF agents in all three serosal surfaces up to 6 weeks postprocedure. Further studies are needed to confirm the anti‐adhesive role of anti‐VEGF agents in pleural and pericardial adhesion experimental models and investigate any effect on anastomosis integrity in peritoneal models.

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Section: Discussionmentioning

confidence: 99%

The anti‐adhesive effect of anti‐VEGF agents in experimental models: A systematic review

Giannis

Geropoulos

Ziogas

et al. 2020

Wound Repair Regeneration

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“…Findings from lymphangiography can help guide surgical options and may even be therapeutic in patients with low-volume lymphatic leakage [ 9 ]. Pleurodesis is another option for patients, though it is typically a salvage treatment for refractory chylothorax in non-surgical candidates [ 9 - 10 ]. It aims to create adhesions between the parietal and visceral pleura to prevent the accumulation of fluid in the space [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Left-Sided Transudative Chylothorax With Concomitant Chylous Ascites in the Setting of Liver Cirrhosis

Gukasyan¹,

Phan²,

Hu³

et al. 2023

Cureus

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Most chylothoraces are caused by trauma and malignancy, and pleural fluid analysis typically demonstrates an exudative effusion. Transudative chylothorax is a rare manifestation and has only been cited in case reports in the current literature. Here, we present the case of a 59-year-old male with a history of liver cirrhosis secondary to alcohol abuse, chronic kidney disease stage 3a, and hypertension who presented with a left-sided pleural effusion and abdominal ascites. A thoracentesis and abdominal paracentesis were performed, and fluid analyses demonstrated a transudative chylothorax with concomitant chylous ascites. In this review, we aim to highlight a rare case of transudative chylothorax and discuss the pathogenesis and management of this condition.

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“…As sclerosant agents, tetracycline, talc, iodopovidone are used to achieve chemical pleurodesis by triggering an inflammatory response [17,18]. According to Rice et al and Mc-Carthy et al, local tetracycline application had no effect on seroma formation after mastectomy and was associated with severe pain [19,20].…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Applications on Postoperative Seroma Formation and Wound Healing Following Mastectomy and Axillary Dissection in Rats

et al. 2021

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The most frequent postoperative complication after breast surgery is seroma formation. Seroma occurs due to lymphatic and vascular fluid leakage into the dead space created by surgical dissection. The objective of the research was to evaluate the effects of local fibrin glue, tetracycline, talc applications, and flap fixation technique on reducing seroma formation after mastectomy and axillary dissection. In addition, we aimed to determine the level of efficacy for these applications, as well as to identify the most appropriate method to be used in operations with high risk of seroma formation. Materials and Methods. This experimental study was conducted using a total of 60 female Wistar albino rats. They were allocated into six groups and each comprised ten rats. Unilateral mastectomy and axillary dissection were performed on all the rats. Local applications of fibrin glue, tetracycline, talc, and alcoholic iodine were performed in four separate groups. Flap fixation technique was applied in one group and those rats that did not receive any intervention constituted the control group. On the 10th postoperative day, seroma was aspirated under anesthesia, and the amount of seroma fluid was recorded. Seroma fluid was analyzed for interleukin 1-β, vascular endothelial growth factor, and C-reactive protein levels. Tissue samples were obtained from the skin overlaying the dissection area, the axilla, and the thoracic wall. Wound healing was evaluated with histopathological examination. Results. Seroma volume was lower and the wound healing scores were the highest in the flap fixation group and the tetracycline group as compared to the control group. However, the alcoholic iodine group and the talc group had a greater amount of seroma (p < 0.05). There was no difference between the fibrin glue group and the control group. Conclusions. In our mastectomy model, local application of alcoholic iodine and talc substances caused more wound site problems and postoperative seroma formation. While fibrin glue did not cause wound site problems, it did increase seroma formation. These three substances were determined to be inefficacious in postoperative seroma formation. Local tetracycline application and flap fixation technique were found to reduce postoperative seroma and benefit wound healing.

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Pleurodesis

Cited by 15 publications

References 99 publications

The anti‐adhesive effect of anti‐VEGF agents in experimental models: A systematic review

The anti‐adhesive effect of anti‐VEGF agents in experimental models: A systematic review

Left-Sided Transudative Chylothorax With Concomitant Chylous Ascites in the Setting of Liver Cirrhosis

Effects of Different Applications on Postoperative Seroma Formation and Wound Healing Following Mastectomy and Axillary Dissection in Rats

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