Pleural thickening caused by leukemic infiltration: CT findings.

Pleural masses may be caused by various conditions, including benign and malignant neoplasms and non-neoplastic tumorlike conditions. Primary pleural neoplasms include solitary fibrous tumor, malignant mesothelioma, and primary pleural non-Hodgkin's lymphoma. Metastatic disease is the most common neoplasm of the pleura and may uncommonly occur in patients with hematologic malignancy, including lymphoma, leukemia, and multiple myeloma. Pleural effusion is usually associated with pleural malignancy. Rarely, pleural malignancy may arise from chronic empyema, and the most common cell type is non-Hodgkin's lymphoma (pyothorax-associated lymphoma). Non-neoplastic pleural masses may be observed in several benign conditions, including tuberculosis, pleural plaques caused by asbestos exposure, and pleural loose body. Herein, we present a review of benign and malignant pleural neoplasms and tumorlike conditions with illustrations of their computed tomographic images.

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“…8B ). Most frequent cause of pleural effusion in patients with leukemia is infection, followed by malignancy, and volume overload ( 16 17 ).…”

Section: Secondary Malignant Neoplasmsmentioning

confidence: 99%

Imaging Features of Various Benign and Malignant Tumors and Tumorlike Conditions of the Pleura: A Pictorial Review

Bae

Kim

Kang

et al. 2020

J Korean Soc Radiol

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“…Leukemic involvement of the pleura manifests with (a) pleural effusion, (b) pleural masses or thickening, or (c) a combination of the two (Figs 8, 9) (27,39). Pleural effusions in patients with leukemia are more likely to be benign than malignant.…”

Section: Pleural Involvementmentioning

confidence: 99%

Leukemic Involvement in the Thorax

et al. 2019

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Leukemias are malignancies in which abnormal white blood cells are produced in the bone marrow, resulting in compromise of normal bone marrow hematopoiesis and subsequent cytopenias. Leukemias are classified as myeloid or lymphoid depending on the type of abnormal cells produced and as acute or chronic according to cellular maturity. The four major types of leukemia are acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia. Clinical manifestations are due to either bone marrow suppression (anemia, thrombocytopenia, or neutropenia) or leukemic organ infiltration. Imaging manifestations of leukemia in the thorax are myriad. While lymphadenopathy is the most common manifestation of intrathoracic leukemia, leukemia may also involve the lungs, pleura, heart, and bones and soft tissues. Myeloid sarcomas occur in 5%-7% of patients with acute myeloid leukemia and represent masses of myeloid blast cells in an extramedullary location. ©

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“…5,30 On CT, leukemic infiltration of the pleura can result in pleural masses or plaquelike areas of pleural thickening associated with areas of interstitial subpleural thickening. 31 Occasionally, subcutaneous nodules (myeloid sarcoma) may also be seen (Fig. 8).…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Myeloid Leukemias and Lung Involvement

Koh

Colby

Müller

2005

Seminars in Respiratory and Critical Care Medicine

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Myeloid leukemias are clonal malignancies characterized by the presence of increased numbers of immature myeloid cells in the marrow and peripheral blood. Pulmonary involvement by myeloid leukemia is relatively uncommon and seen mainly in patients with severe disease. The most common form of pulmonary involvement consists of leukemic infiltration along the lymphatics in the peribronchovascular, septal, and pleural interstitial tissue. Less common manifestations include myeloid sarcoma, leukostasis, leukemic cell lysis pneumopathy, and hyperleukocytic reaction. The radiological manifestations of pulmonary leukemic cell infiltration and leukostasis consist mainly of bilateral thickening of the peribronchovascular interstitium and interlobular septa, a pattern that resembles that of interstitial pulmonary edema. The radiological manifestations of leukemic cell lysis pneumopathy and hyperleukocytic reaction consist of symmetric bilateral areas of consolidation. This manuscript reviews the histological and radiological intrathoracic manifestations of myelogenous leukemias.

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Pleural thickening caused by leukemic infiltration: CT findings.

Cited by 14 publications

References 3 publications

Imaging Features of Various Benign and Malignant Tumors and Tumorlike Conditions of the Pleura: A Pictorial Review

Imaging Features of Various Benign and Malignant Tumors and Tumorlike Conditions of the Pleura: A Pictorial Review

Leukemic Involvement in the Thorax

Myeloid Leukemias and Lung Involvement

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