Pleural synovial sarcoma patient treated with combined chemotherapy and Endostar, plus sunitinib maintenance therapy: A case report and review of the literature

Abstract

Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human endostatin (Endostar) combined with chemotherapy for a total of six cycles, followed by sunitinib maintenance therapy. To the best of our knowledge, this is the first reported use of sunitinib for maintenance therapy in pleural synovial sarcoma. The patient survived for 25 months after the recurrence of the disease following surgery. The results indicate that this combination therapy was effective in the treatment of pleural synovial sarcoma. The present study also briefly reviews the literature on pleural synovial sarcoma, and the features and treatments for this rare case are discussed.

Recombined humanized endostatin (Endostar) combined with chemotherapy for advanced bone and soft tissue sarcomas in stage IV

“…The results show that Endostar combined with chemotherapy result in a higher CBR and a longer median PFS in the patients with advanced sarcoma (8.6 months versus 4.4 months), with tolerable toxicity, which are consistent with previous reports of endostar combined with chemotherapy in other solid tumors [26–28]. In our study, the PFS of the combined group is significantly longer than that of the control group.…”

Extensive surgical resections for rare pleural neoplasms: A single-center experience with a yolk sac tumor and synovial sarcoma.

“…(18) Since then, few cases have been reported by others. (17,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) A range of treatments have been suggested for pleural synovial sarcoma including extensive surgical resection, (neo)adjuvant chemotherapy (with ifosfamide and doxorubicin), and radiotherapy. (19,(24)(25)(26)(28)(29)(30)(31) Complete surgical resection appears to be associated with improved survival outcomes.…”

Successful treatment of relapsed testicular embryonal rhabdomyosarcoma with Endostar and traditional chemotherapy: a case report

“…In a study of advanced bone and STSs, Endostar combined with chemotherapy had significant activity toward increasing PFS and improving the clinical benefit rate 11. Teng et al reported that the treatment of a pleural synovial sarcoma patient with combined chemotherapy and Endostar plus sunitinib was effective 12. A retrospective case series study with a total of 71 patients suffering from advanced STSs suggested that Endo-star combined with chemotherapy had a higher disease control rate and longer PFS than traditional chemotherapy 13…”