Pleural mesothelioma of connective tissue type, localized fibrous tumour of the pleura, and reactive submesothelial hyperplasia. An immunohistochemical comparison

Abstract

Ten diffuse pleural mesotheliomas of connective tissue type have been compared with 14 examples of pleural granulation tissue and 7 localized fibrous tumours of the pleura, using immunohistochemistry to identify cytokeratins of low and high molecular weight and vimentin. Low molecular weight cytokeratin and vimentin were both detected in 8 of the 10 mesotheliomas and in 12 of the 14 reactive lesions. High molecular weight cytokeratin was rarely detected in either lesion. The seven localized fibrous tumours of the pleura were all positive for vimentin and negative for both cytokeratins. These findings support an origin of connective tissue type mesotheliomas from multipotential submesothelial spindle cells and of localized fibrous tumours of the pleura from either conventional fibroblasts or resting submesothelial spindle cells. Antibodies to cytokeratin help distinguish these two neoplasms but provide no assistance in the more difficult diagnostic problem of distinguishing mesotheliomas of connective tissue type from pleural reactions characterized by abundant granulation tissue.

Tumor Fibroso Solitario De Pleura: A Propósito De Un Caso Clínico en El Hospital Nacional Edgardo Rebagliati Martins

“…El desarrollo posterior de la microscopía electrónica e inmunohistoquímica estableció su origen en la capa submesotelial descartando un origen mesotelial 5,6 ,permitiendo diferenciar los tumores fibrosos solitarios de la pleura de los mesoteliomas.…”

Tumor fibroso solitario de la pleura asociado a síndromes paraneoplásicos

“…El desarrollo posterior de la microscopía electrónica e inmunohistoquímica estableció su origen en la capa submesotelial descartando un origen mesotelial 9,10 , permitiendo diferenciar los TFSP de los mesoteliomas.…”

Solitary Fibrous Tumor of the Pleura: A Clinicopathologic Analysis of Five Patients

“…Zamanla elektron mikroskopi ve immünohistokimyasal çalışmalarla mezotel dışında submezotelyal mezenkim kökenli olduğu tespit edilerek soliter (veya lokalize) fibröz tümör terimi kullanılmaya başlanmıştır [12]. Plevra kaynaklı tüm tümörlerin %5'inden azını oluştur-maktadır [2].…”