Pleural Mesothelioma and Membranous Nephropathy

Abstract

Underlying malignancy has been thought to be responsible for 5–10% of the cases of membranous nephropathy in adults, with the risk being highest in patients over the age of 60 years. Solid tumors such as carcinomas of lung or colon, are most often involved. It is presumed that tumor antigens are deposited in the glomeruli; this is followed by antibody deposition and complement activation, leading to epithelial cell and basement membrane injury and proteinuria due to the associated increase in glomerular permeability. We describe a patient with a resistant nephrotic syndrome and massive proteinuria due to membranous nephropathy associated with pleural mesothelioma.

Malignant mesothelioma‐associated antigens recognized by tumor‐infiltrating B cells and the clinical significance of the antibody titers

“…As shown in Figure 4, the antibody titers the antibody titers were examined by the ELISA system against 6 synthesized peptides of Gene-X and THBS-2. As shown in Figure 4, the antibody titers of Gene-X [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] and THBS-2 [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] were well correlated with the results by phage plaque assay. Therefore, antibody titers against Gene-X 40-59 and THBS-2 [26][27][28][29][30][31][32][33][34][35]…”

“…Moreover, membranous nephropathy had been reported to be associated with MPM. (40,41) The causal relationship between IFT-88 and membranous nephropathy should therefore be elucidated in a further study.…”

“…Therefore, antibody titers against Gene-X 40-59 and THBS-2 [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] Table 5). The titers of antibodies against Gene-X 40-59 and THBS-2 [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] were analyzed in lung cancer patients with or without asbestos exposure and breast cancer patients (Fig. 5a,b).…”

“…5a,b). Among the 47 patients with lung cancer and 16 patients with breast cancer, all patients showed negative levels of the antibodies against Gene-X 40-59 and THBS-2 [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] . In order to evaluate the effect of surgical resection of MPM on the antibody titers, postoperative sera of patients M15 and M18 were subjected to the analyses.…”

An Autopsy Case of Malignant Pleural Mesothelioma Associated with Nephrotic Syndrome

“…However, a review of the English literature identified seven reported cases of malignant mesothelioma associated with nephrotic syndrome (3)(4)(5)(6)(7)(8)(9). Among these seven cases, the primary site of mesothelioma was the pleura in five cases, peritoneum in one case and tunica vaginalis testis in one case.…”