Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement

Commentary: The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples

“…Malignant pleural mesothelioma is an aggressive malignancy that has been associated with various controversies in regard to its prevention, diagnosis and treatment ( 2 , 3 ). Among these controversies one could include the amphibolous role of iron homeostasis after exposure to asbestos in the development of mesothelioma ( 1 , 6 ).…”

“…(i) Malignant pleural mesothelioma remains one of the most controversial and scientifically interesting malignancies as far as pathogenesis, prevention and treatment are concerned. Well-known are, for example, the long debates about the role of extended surgical therapy in form of extrapleural pneumonectomy in comparison with less radical procedures (pleurectomy/decortication) ( 2 ) and the role of the still under investigation novel therapies in form of monoclonal antibodies ( 3 ).…”