BackgroundLipomas arising from the intrathoracic pleura are exceedingly rare. Few cases have been reported worldwide. To our knowledge, this presented case is one of the few cases reported. Here we report a single case as intrathoracic lipoma that arose from the mediastinal pleura of the left pericardium. Here the tumor was completely resected by uniportal video assisted thoracic surgery. Case presentationA 64-year-old female presented with a symptomatic left chest pain, which was confirmed to be an lipomatous tumor using computed tomography. An oval extrapericardial lipoma originating from the mediastinal pleura was resected through uniportal video assisted thoracic surgery. Pathological examination indicated a diagnosis of pleura lipoma. ConclusionThe tumor was infectious and relatively hyperemia when detected during a medical checkup. We enabled the successful tumor excision via uniportal video assisted thoracic surgery approach. Extratumoral haemorrhage was confirmed during the operation. Although intrathoracic pleural lipomas are histologically benign, careful observation and follow-up are crucial due to the possibility of recurrence.