Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma

Hokka, Daisuke; Uchino, Kenji; Tane, Kenta; Ogawa, Hiroyuki; Tane, Sinya; Tanaka, Yugo; Tauchi, Shunsuke; Nishio, Wataru; Yoshimura, Masahiro; Maniwa, Yoshimasa

doi:10.3892/mco.2014.416

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…One article was excluded because lavage cytology was not performed in the pleural cavity [ 43 ]. Finally, 28 articles were included in the present analysis [ 7 , 9 , 10 , 12 , 13 , 44 – 66 ]. The selection process is shown in Fig 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The sample size of the included trials ranged from 84 to 4,171 individuals. Among these studies, 6 were conducted in Europe [ 10 , 45 , 47 , 49 , 52 , 65 ]; 20 in Japan [ 7 , 9 , 12 , 13 , 44 , 46 , 50 – 51 , 53 – 57 , 59 – 64 , 66 ]; and one each in the USA and China [ 48 , 58 ]. Among the 28 studies included here, 22 reported the survival rate of positive PLC versus negative PLC before resection, 5 reported the survival rate after resection, and 2 had PLC data from both pre- and post-resection.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis

Wang

Ling

et al. 2016

PLoS ONE

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ObjectivePleural lavage cytology (PLC) is considered as a possible tool for assessing prognosis of lung cancer patients. We aimed to comprehensively review the prognosis value of PLC in patients undergoing surgical resection.MethodsWe searched 4 electronic databases for relevant studies comparing positive PLC and negative PLC. The primary outcomes included survival rate and recurrence rate at maximum follow-up.ResultsThe meta-analysis included 28 studies, with a total of 20,714 patients. For the overall survival rate of all stages, the results demonstrated that positive pre-resection, post-resection and pooled PLC were associated with unfavorable survival: hazard ratio (HR) 2.89 (95% confidence interval [CI] 2.48–3.37), 2.70 (1.90–3.83), and 2.89 (2.52–3.31), respectively. For the stage I survival rate, the combined results also suggested that positive pre-resection, post-resection and pooled PLC were associated with unfavorable survival: HR 3.29 (95% CI 2.55–4.25), 4.85 (2.31–10.20), and 3.16 (2.53–3.94), respectively. Furthermore, a meta-analysis of 14 studies included 14,279 patients showed that positive pre-resection, post-resection and pooled PLC were associated with an increased risk of overall recurrence: risk ratio (RR) 2.45 (95% CI 1.91–3.15), 2.37 (1.11–5.09), and 2.37 (95% CI 2.00–2.80), respectively. Positive PLC was also associated with a high pleural recurrence (RR 4.77; 95% CI 3.13–7.26) or distant recurrence (RR 2.33; 95% CI 1.65–3.29).ConclusionsBoth positive pre- resection and post-resection PLC are associated with not only higher tumor recurrence but also unfavorable survival outcomes in patients with lung cancer resection. This technique can therefore act as a strong prognostic factor for tumor recurrence and adverse survival rates.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis

Wang

Ling

et al. 2016

PLoS ONE

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“…The frequency at which they are found before any manipulation of the lung tumor during surgery is variable, but averaged 5.8 and 7.1% in two meta-analyses comprising 8763 [20] and 9935 [21] patients, respectively. A positive intraoperative PLC is an independent predictor of lung cancer recurrence (both local and distant) [21,22] and unfavorable survival [20,23]. For example, in a Japanese registry of 4171 patients with lung cancer who underwent PLC, 217 (5.2%) had positive results [24].…”

Section: Pleural Lavage Cytologymentioning

confidence: 99%

Malignant pleural effusions because of lung cancer

Porcel¹

2016

Current Opinion in Pulmonary Medicine

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“…It is positive in between 3 and 7% of patients, even in those with stage I adenocarcinoma. A positive pleural lavage is consistently associated with higher rates of recurrence and lower survival in reported series [143][144][145][146][147][148][149][150] and in meta-analyses [151][152][153]. It has been suggested to increase the T category of those tumours with positive pleural lavage cytology, but it already has a code in the TNM staging system: R1 (cy+).…”

Section: Intrathoracic Staging At Pulmonary Resectionmentioning

confidence: 99%

Lung cancer staging: a concise update

et al. 2018

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Diagnosis and clinical staging of lung cancer are fundamental to planning therapy. The techniques for clinical staging, anatomic and metabolic imaging, endoscopies and minimally invasive surgical procedures, should be performed sequentially and with an increasing degree of invasiveness. Intraoperative staging, assessing the magnitude of the primary tumour, the involved structures, and the loco-regional lymphatic spread by means of systematic nodal dissection, is essential in order to achieve a complete resection. In resected tumours, pathological staging, with the systematic study of the resected specimens, is the strongest prognostic indicator and is essential to make further decisions on therapy. In the present decade, the guidelines on lung cancer staging of the American College of Chest Physicians and the European Society of Thoracic Surgeons are based on the best available evidence and are widely followed. Recent advances in the classification of the adenocarcinoma of the lung, with the definition of adenocarcinoma , minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma, and the publication of the eighth edition of the tumour, node and metastasis classification of lung cancer, have to be integrated into the staging process. The present review complements the latest guidelines on lung cancer staging by providing an update of all these issues.

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Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma

Cited by 8 publications

References 18 publications

Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis

Prognostic Value of Pleural Lavage Cytology in Patients with Lung Cancer Resection: An Updated Meta-Analysis

Malignant pleural effusions because of lung cancer

Lung cancer staging: a concise update

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