Pleural fluid neopterin levels in tuberculous pleurisy

Çok, Gürsel; Parildar, Zuhal; Basol, Gunes; Kabaroğlu, Ceyda; Bayındır, Ülkü; Habif, Sara; Bayındır, Oya

doi:10.1016/j.clinbiochem.2007.04.009

Cited by 18 publications

(17 citation statements)

References 30 publications

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“…However, variability in its sensitivity and specificity precludes its regular use. [30][31][32] Leptin is an adipose-derived hormone involved in metabolism. Celik et al found that pleural-fluid leptin levels were lower in tuberculous effusions than in other exudates, with both a sensitivity and specificity of 82%.…”

Section: Pleural Fluid: Adenosine Deaminasementioning

confidence: 99%

Pleural fluid characteristics of tuberculous pleural effusions

McGrath¹,

Warriner²,

Anderson³

2010

Heart & Lung

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Section: Pleural Fluid: Adenosine Deaminasementioning

confidence: 99%

Pleural fluid characteristics of tuberculous pleural effusions

McGrath¹,

Warriner²,

Anderson³

2010

Heart & Lung

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“…Very high levels of neopterin have been observed in uremic pleural effusions [27], raising doubts about its specificity for TB. In one study that used histological evidence of caseating granuloma as the reference standard for TB, the sensitivity and specificity of neopterin were 44 and 85%, respectively [25]. In a second study, which used ADA as the reference standard, the sensitivity was 85% and the specificity was 93% [26].…”

Section: Neopterinmentioning

confidence: 99%

“…Neopterin levels in pleural fluid have been found to be higher in patients with TB than patients with malignancy [24,25] or other [26] conditions. Very high levels of neopterin have been observed in uremic pleural effusions [27], raising doubts about its specificity for TB.…”

Section: Neopterinmentioning

confidence: 99%

Novel tests for diagnosing tuberculous pleural effusion: what works and what does not?

Trajman

Pai²,

Dheda³

et al. 2008

European Respiratory Journal

138

121

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Tuberculous pleuritis is a common manifestation of extrapulmonary tuberculosis and is the most common cause of pleural effusion in many countries. Conventional diagnostic tests, such as microscopic examination of the pleural fluid, biochemical tests, culture of pleural fluid, sputum or pleural tissue, and histopathological examination of pleural tissue, have known limitations. Due to these limitations, newer and more rapid diagnostic tests have been evaluated. In this review, the authors provide an overview of the performance of new diagnostic tests, including markers of specific and nonspecific immune response, nucleic acid amplification and detection, and predictive models based on combinations of markers. Directions for future development and evaluation of novel assays and biomarkers for pleural tuberculosis are also suggested.

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“…Similar to this study, we did not observe any conversion to exudate in pleural effusions of congestive heart failure patients, although they were using the diuretics. A lot of work associated with neopterin metabolism were based on the measurement of completely oxidized neopterin with high-performance liquid chromatography (HPLC) or radioimmunassay [14][15][16]. In our study, we used the enzymeimmune-assay method to find pleural fluid neopterin level.…”

Section: Discussionmentioning

confidence: 99%

Place of neopterin level in the differential diagnosis of tuberculosis pleurisy

Duksal¹,

Döngel

Duksal³

et al. 2013

Basic Clin Sci

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AbsractAim. Tuberculous pleurisy is one of the most common form of pulmonary tuberculosis, and may be confused with many other diseases. This study was designed to assess the diagnostic value of pleural fluid neopterin levels in patients with tuberculous pleurisy. Methods. A total of 57 patients [tuberculosis pleurisy (n=30), malignant pleural effusion (n=17), pleural effusion due to congestive heart failure (n=10)] were included in the study. The measurement of neopterin levels was conducted by the enzymeimmunassay method and Trinity-Biotech XL fully automatic ELISA kit device and neopterin IBL kit. Results. The neopterin levels in patients with tuberculous pleurisy were significantly higher than that of both malignancy and congestive heart failure (p<0.001). The neopterin levels of patients with congestive heart failure and malignancy were found as similar (p=0.920). There was no significant difference in the neopterin levels with regard to age and sex (p>0.05). Conclusions. Tuberculous pleurisy increases neopterin levels of pleural fluid when compared with malignancy and congestive heart failure. In this respect, neopterin level in the pleural fluid may be a useful diagnostic marker of tuberculous pleurisy.Keywords: Neopterin; pleural effusion; tuberculous pleurisy Özet Amaç. Tüberküloz plörezi akciğer tüberkülozunun en sık formlarından biri olup birçok hastalıkla karışabilir. Bu çalışma tüberküloz plörezili hastaların plevral sıvılarındaki neopterin seviyelerinin tanısal değerini belirlemek için yapılmıştır. Yöntem. Toplam 57 hasta [tüberküloz plörezi (n=30), malign plevral efüzyon (n=17) ve konjestif kalp yetmezliği

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Pleural fluid neopterin levels in tuberculous pleurisy

Cited by 18 publications

References 30 publications

Pleural fluid characteristics of tuberculous pleural effusions

Pleural fluid characteristics of tuberculous pleural effusions

Novel tests for diagnosing tuberculous pleural effusion: what works and what does not?

Place of neopterin level in the differential diagnosis of tuberculosis pleurisy

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