Pleural fluid lysozyme in tuberculous and non-tuberculous pleurisy.

Klockars, Matti; Petterson, T; Riska, Henrik; Hellström, P E

doi:10.1136/bmj.1.6022.1381

Cited by 16 publications

(7 citation statements)

References 3 publications

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“…In bacterial meningitis the isoenzymic pattern of LDH in cerebrospinal fluid suggests that this enzyme does not originate either in serum or in the central nervous system but is derived from cere-brospinal granulocytes (1). That under normal conditions almost 80 % of plasma LZM is derived from the turnover of neutrophilic granulocytes (2); that LZM is present in high concentrations in other pyogenic exudates (3,7); and that in this study LZM levels correlated significantly with LDH levels in cerebrospinal fluid all point to the granulocytic origin of the LZM in cerebrospinal fluid. No correlation has been observed between the concentration of LDH and the granulocyte count in cerebrospinal fluid, neither did the LZM levels correlate with granulocyte counts.…”

Section: Discussionsupporting

confidence: 62%

Cerebrospinal Fluid Lysozyme in Bacterial and Viral Meningitis

Klockars

Reitamo

Weber

et al. 1978

Journal of Internal Medicine

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ABSTRACT. The concentration of lysozyme (LZM) in cerebrospinal fluid was determined in 25 patients with bacterial meningitis, in 18 patients with viral meningitis and in 25 control patients who had other febrile illnesses. The concentration of LZM was less than 1.5 μg/ml in all control patients, and slightly to markedly raised in 10 patients with viral meningitis and in 11 out of 13 patients with untreated bacterial meningitis. The concentration of LZM was significantly different in the viral and bacterial meningitis paitents (p <0.001). Most raised concentrations of cerebrospinal fluid LZM persisted for at least one week after the start of antibiotic treatment. The concentrations of LZM correlated well with concentrations of lactic dehydrogenase. These results show that the determination of cerebrospinal fluid LZM is a useful tool in the differential diagnosis of menigitis, particularly when the prehospital treatment with antibiotics may be responsible for a diagnostically misleading negative bacterial culture of the cerebrospinal fluid and altered cerebrospinal fluid cytology.

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Section: Discussionsupporting

confidence: 62%

Cerebrospinal Fluid Lysozyme in Bacterial and Viral Meningitis

Klockars

Reitamo

Weber

et al. 1978

Journal of Internal Medicine

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“…Others have indicated that malnutrition, impaired cellular immunity, disrupted microvascular circulation due to diabetes mellitus (15,16) and surgical procedures (17) can enhance the development of pleuritis in infections caused by NTM. Pleuritis caused by NTM in a non-immunocompromised patient is very rare (18,19 (20,21). In the previous reports of M. avium pleuritis, culture or PCR method of pleural effusion detected M. avium (15,(17)(18)(19) …”

Section: Although the Clinical Features Of Infection With Nontuberculmentioning

confidence: 99%

Mycobacterium avium Pleuritis in a Non-Immunocompromised Patient

et al. 2008

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“…66 Cultures of biopsy specimens are positive for growth of tubercle bacilli in 55 to 80 percent of patients. 104,105 In 60 to 80 percent of patients with proved tuberculosis, pleural biopsy specimens reveal caseous granulomas. 93 Among the 526 reported biopsies in patients who were ultimately proven to have tuberculosis, 65 percent were diagnostic of the underlying condition.…”

Section: Commentsmentioning

confidence: 99%