Pleural-Fluid Eosinophilia

MacMurray, Frank G.; Katz, S; Zimmerman, Hyman J.

doi:10.1056/nejm195008312430902

Cited by 22 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eosinophils are often observed in pleural effusion associated with pneumothorax, asbestosis, pulmonary infarction, sarcoidosis and collagen vascular disease [404,405]. In addition, eosinophils occur in pleural effusion of unknown cause.…”

Section: Eosinophilic Pleural Effusionmentioning

confidence: 99%

“…In addition, eosinophils occur in pleural effusion of unknown cause. Although the pathogenic significance of pleural eosinophils is not yet clear, their presence appear to reduce the likelihood of an underlying malignant disease or pulmonary tuberculosis [404][405][406][407][408]. Recent reports have shown that eosinophilic pleural effusions contain significant concentrations of IL-5, GM-CSF and interleukin-3 (IL-3) and that these factors contribute to eosinophil proliferation and survival [225].…”

Section: Eosinophilic Pleural Effusionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Kroegel¹,

Warner²,

Jc³

et al. 1994

Eur Respir J

View full text Add to dashboard Cite

The second part of this review on eosinophils focuses on biological cell functions and surveys the various deleterious mechanisms involved in the eosinophil-dominated inflammatory reaction. It discusses the possible pathogenic role of eosinophils in several eosinophil-related diseases, such as parasitic infections, interstitial lung disorders and bronchial diseases, graft rejection, vasculitic granulomatous disorders, pleural effusion, and bronchogenic tumours.The final section of the article highlights the possible recent pharmacological and future therapeutic approaches in modifying eosinophil recruitment and function. Eur Respir J., 1994, 7, 743-760 This paper is published as a follow-on to "Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)"* (Eur Respir J, 1994; 7: 519-543). Biological cell functionsThe eosinophil mediates its effector functions through various distinct cellular mechanisms, namely nonoxidative, oxidative, and humoral mechanisms ( fig. 7). Nonoxidative mechanismsAs mentioned previously, the three basic proteins as well as eosinophil peroxidase (EPO) have toxic properties independent of molecular oxygen species. For instance, major basic protein (MBP) [323], eosinophil cationic protein (ECP) [324] and EPO in the presence of hydrogen superoxide and a halide [99] kill helminthic parasites in vitro. In addition, these proteins are toxic for tumour cells and/or mammalian cells [325], including human pulmonary parenchyma and interstitial matrix [326,327], cultured human lung epithelial cells [328], and guinea-pig respiratory epithelium [252, 253,329]. Furthermore, it has been demonstrated that MBP damages human bronchial epithelium, which consists of desquamation and destruction of ciliated cells [329]. Finally, release of their granule proteins by plateletactivating factor (PAF)-activated intact eosinophils has been shown to imitate the characteristic pathological findings of airway epithelium in asthma [330].In addition to their cytotoxic action, eosinophil cationic proteins at certain subtoxic concentrations also stimulate other inflammatory cells. For instance, MBP and ECP have been shown to degranulate platelets [305], induce histamine release from mast cells and basophils [240, 245,331], as well as superoxide anion generation and lysosomal enzyme release by human neutrophils [264].Finally, eosinophil proteins may affect airway muscle function and hyperresponsiveness. Recent reports investigating the effects of direct intratracheal instillation of purified eosinophil granule proteins on pulmonary function and airway responsiveness in primates [281,332] have shown that MBP induces a dose-related increase in airway responsiveness to inhaled methacholine. In the same model, both MBP and EPO caused a transient bronchoconstriction immediately after instillation, that resolved within 1 h. Interestingly, other eosinophil granular proteins failed to effect airway responsiveness or pulmonary function.Mode of action. The mode of action of these basic proteins is n...

show abstract

Section: Eosinophilic Pleural Effusionmentioning

confidence: 99%

Section: Eosinophilic Pleural Effusionmentioning

confidence: 99%

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Kroegel¹,

Warner²,

Jc³

et al. 1994

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Eosinophilic pleural effusion from any cause is uncommon (Campbell and Webb, 1964), and only one reported case was associated with malignant lymphoma (MacMurray, Katz, and Zimmerman, 1950).…”

Section: Discussionmentioning

confidence: 99%