Pleural effusions in systemic amyloidosis

Berk, John L.

doi:10.1097/01.mcp.0000162378.35928.37

Cited by 40 publications

(35 citation statements)

References 29 publications

(12 reference statements)

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“…Pleural effusions are an uncommon complication of systemic amyloidosis, most frequently occurring in AL amyloidosis (*6%-18% of cases) [1]. Management of patients with primary systemic amyloidosis and pleural effusions is challenging and once refractory effusions develop, prognosis is poor.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis

et al. 2007

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Refractory pleural effusions present a challenging management problem and are associated with a poor prognosis in patients with primary systemic amyloidosis (AL). We report a series of four patients with AL who presented with bilateral pleural effusions that were refractory to diuretic therapy. After treatment with bevacizumab, an antivascular endothelial growth factor (VEGF) antibody, three of the four patients had improvement in their pleural effusions, peripheral edema, and functional status. Additional studies are needed to further define the role of bevacizumab in the management of this group of patients. Am. J. Hematol. 82:409-413, 2007. V V C 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

“…Management of patients with systemic amyloidosis (AL) who present with diuretic-refractory pleural effusions is challenging and is associated with a poor prognosis [1]. As there are few alternatives for patients who fail conventional treatment, new approaches for pleural effusion management in these patients are needed.…”

Section: Introductionmentioning

confidence: 99%

Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis

et al. 2007

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“…Pleural effusions appear to occur not infrequently in patients with systemic amyloidosis, (17), with the most frequent cause being congestive heart failure. Other explanations include liver failure, nephritic syndrome, and direct pleural deposition with amyloidosis (18).…”

Section: Discussionmentioning

confidence: 99%

Waldenström's Macroglobulinemia Accompanying Systemic Amyloidosis: The Usefulness of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Detecting Amyloid Deposits

Ishiguro¹,

Takayanagi²,

Katoh

et al. 2014

Intern. Med.

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A 75-year-old man with a history of dyspnea lasting for three years presented to our hospital. Chest computed tomography showed bilateral pulmonary nodules, some of which were calcified, in addition to mediastinal/hilar lymphadenopathy and bilateral pleural effusions. Endobronchial ultrasound-guided (EBUS) transbronchial needle aspiration (TBNA) of the subcarinal lymph nodes showed amorphous acellular material compatible with λ-light chain amyloid deposits. Sternal bone marrow aspiration demonstrated increased small lymphocytes admixed with plasma cells and plasmacytoid lymphocytes. Serum immunoglobulin values were decreased with the exception of immunoglobulin M monoclonal peak. We subsequently diagnosed the patient as having Waldenström's macroglobulinemia accompanying AL-type amyloidosis. In this case, EBUS-TBNA was useful for detecting AL-type amyloidosis.

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“…The English literature, between the years 1977 and 2010, includes 25 case reports of PEs associated with AL, 21 of which document pleural amyloid infiltration [10,41,42,43,44,45,46]. Pleural fluid analysis revealed that 10 out of 17 patients (60%) presented with an exudate, while the rest of the patients (40%), all with congestive heart failure associated with AL, had a transudate.…”

Section: Amyloidosismentioning

confidence: 99%

Mechanisms of Pleural Involvement in Orphan Diseases

Anevlavis

Τzouvelekis²,

Bouros³

2012

Respiration

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Over the past 10 years, the widespread clinical applicability of semi-invasive and noninvasive diagnostic tools including medical thoracoscopy and ultrasonography has expanded the occurrence of pleural effusions to include several rare diseases such as granulomatous, connective tissue and autoimmune disorders including sarcoidosis, granulomatosis with polyangiitis (Wegener’s), systemic sclerosis, lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, amyloidosis, Langerhans cell histiocytosis, and others. The purpose of this review is to summarize the current state of the knowledge regarding pathogenetic mechanisms of pleural involvement in rare disease entities and to highlight the need for more efforts to understand the underlying mechanisms for a more effective therapy.

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Pleural effusions in systemic amyloidosis

Cited by 40 publications

References 29 publications

Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis

Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis

Waldenström's Macroglobulinemia Accompanying Systemic Amyloidosis: The Usefulness of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Detecting Amyloid Deposits

Mechanisms of Pleural Involvement in Orphan Diseases

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