Pleural Effusion in Churg-Strauss Syndrome

Erzurum, Serpil C.; Underwood, Gregory A.; Hamilos, Daniel L.; Waldron, James A.

doi:10.1378/chest.95.6.1357

Cited by 54 publications

(12 citation statements)

References 6 publications

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“…The peripheral eosinophil count usually drops very rapidly after the onset of the corticosteroid treatment, and rises if the disease relapses [8]. Marked pleural eosinophilia is also common in patients with pleural effusions [9]. However, our patient's peripheral eosinophil count was not significantly correlated to disease activity, and eosinophils were not found in the pleural effusion.…”

Section: Discussionmentioning

confidence: 68%

Multiple Colonic Ulcers Caused by Churg–Strauss Syndrome in a 15-Year-Old Girl

Lin¹,

Wang²,

Liu³

et al. 2001

Clin Rheumatol

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Churg-Strauss syndrome (CSS), or allergic granulomatous angiitis, is an uncommon vasculitic syndrome that is found mainly in middle-aged adults. We describe a 15-year-old girl with CSS, diagnosed by histological findings and characteristic clinical features. The patient experienced two episodes of catastrophic gastrointestinal vasculitis, resulting in resection of 150 cm of small intestine and right hemicolectomy. Colonoscopic examination showed multiple colonic ulcers with active bleeding. The clinical course of the patient was grave and refractory to the therapy of steroid and cytotoxic drugs. In the world literature only two patients with multiple colonic ulcers caused by CSS have been reported, and very rare cases of childhood-onset CSS have been published. We reviewed CSS in children and found that the prognosis was poorer than that in adults.

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Section: Discussionmentioning

confidence: 68%

Multiple Colonic Ulcers Caused by Churg–Strauss Syndrome in a 15-Year-Old Girl

Lin¹,

Wang²,

Liu³

et al. 2001

Clin Rheumatol

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“…190 A PE may also be present in druginduced lupus, but typically resolves after drug withdrawal. [191][192][193][194][195][196][197][198][199][200][201][202] In systemic diseases, the PE may be produced by direct infiltration of the pleura, by an immune mechanism, by renal or cardiac involvement that can accompany these conditions, as well as by the presence of a thromboembolic disease or by drugs. 180 The rest of the systemic diseases in which a PE may be present, 146 as well as their principal characteristics, are summarized in Table 19.…”

Section: Systemic Lupus Erythematosus (Le)mentioning

confidence: 99%

The Art of Pleural Fluid Analysis

Sahn

Huggins

José³

et al. 2013

Clinical Pulmonary Medicine

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Although a pleural effusion (PE) is a common condition in clinical practice (with a prevalence of slightly > 400 patients/100,000), a definitive diagnosis is not established in approximately 20% of cases. In the classic publications, thoracentesis provided a definitive or presumptive diagnosis in 73% of cases, although it is estimated that today this percentage could reach 95%. An undiagnosed PE is defined as one that remains of unknown origin after performing complete pleural fluid analysis (nucleated cell counts with differential diagnosis, biochemistry, culture, cytology, and flow cytometry). The aim of this paper is to review the difficulties that may be encountered when attempting to establish the cause of a PE. The reason for this diagnostic dilemma may be an atypical clinical or radiologic presentation or falsepositive or false-negative results. Furthermore, the limited frequency of some PEs is often not considered when determining the differential diagnosis.

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“…1b) (11)(12)(13). In biopsy specimens of CSS, eosinophilic inflammation in the subpleural and interlobular connective tissue and lymphatic luminal dilatation has been reported (8,9). Marked extravascular infiltration of eosinophils in the pleura causes the development of EPE and also presents the early (prevasculitic) phase of the CSS.…”

Section: F I G U R E 3 Ct O F T H E C H E S T O N a D Mi S S I O N mentioning

confidence: 99%