Pleural and peritoneal leishmaniasis in an AIDS patient

Muñoz-Rodríguez, Francisco José; Padro, Silvina; Pástor, Pau; Rosa-Re, D; Valls, María Eugenia; Miró, Josep M.; Gatell, JM

doi:10.1007/bf01709591

Cited by 19 publications

(7 citation statements)

References 6 publications

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“…A similar pulmonary pathology involving foci of septal fibrosis and interstitial pneumonitis with a predominance of mononuclear cells has also been described in humans [85]. Other forms in which the disease presents itself are granulomatous inflammation of the bronchial mucosa and mediastinal lymph nodes [86], and the development of pleural effusions with the presence of the intracellular protozoon in macrophages [87,88]. In other types of samples of the respiratory apparatus, such as transbronchial biopsy [89] and bronchoalveolar lavage [90,91], the presence of Leishmania amastigotes has also been detected.…”

Section: Genus Leishmaniamentioning

confidence: 62%

Protozoa in respiratory pathology: a review

Martínez‐Girón¹,

Esteban²,

Ribas³

et al. 2008

European Respiratory Journal

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Among the micro-organisms that may affect the respiratory apparatus are the protozoa. The diseases they may give rise to constitute a relatively uncommon group of respiratory ailments with, in the majority of cases, an underlying clinical situation corresponding to states of suppressed immunity (AIDS, transplants, malign haemopathies, corticotherapy, etc.). Other factors, such as visits to endemic areas and immigration, also have to be taken into account.In view of the probable increase in the number of cases and the appearance of new emerging diseases, it is the intention of the present work to review the publications available, in different fields of medicine, that refer to the principal kinds of protozoa (Entamoeba,

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Section: Genus Leishmaniamentioning

confidence: 62%

Protozoa in respiratory pathology: a review

Martínez‐Girón¹,

Esteban²,

Ribas³

et al. 2008

European Respiratory Journal

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“…Involvement of the oral mucosa, esophagus, stomach, peritoneum and small intestine are reported as well (3,13,14). Another symptom previously reported among HIV-infected patients is the lower respiratory tract involvement in immunocompromised patients (3)(4)(5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 87%

“…The clinical manifestations of leishmaniasis depend on complex interactions resulting from the parasite's invasiveness, tropism and pathogenicity, and the host's genetically determined immune responses. Lower respiratory tract and peritoneal involvement in immunocompetent individuals are rare (3,4), but it has been described in HIV-infected patients (5)(6)(7)(8)(9). The present study reports an atypical case of visceral leishmaniasis with pulmonary and peritoneal involvement in a Brazilian patient with AIDS diagnosed by microscopy and polymerase chain reaction (PCR) detection of Leishmania chagasi in the pleural and ascitic fluid.…”

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confidence: 99%

Microscopy and Polymerase Chain Reaction Detection ofLeishmania chagasiin the Pleural and Ascitic Fluid of a Patient with AIDS: Case Report and Review of Diagnosis and Therapy of Visceral Leishmaniasis

Diehl

Santos

Zimmerman

et al. 2004

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Atypical visceral leishmaniasis is increasingly reported in immunocompromised patients, including patients with AIDS. A case of visceral leishmaniasis in an HIV-infected Brazilian patient with pulmonary and peritoneal involvement is reported. Histological evaluation of pleural fluid and ascites aspirate revealed macrophages with intracellular Leishmania. Polymerase chain reaction analysis was positive for Leishmania in the pleural and ascitic fluid with use of primers specific for Leishmania chagasi. In addition to classical methods for diagnosing leishmaniasis, such as microscopy and culture, polymerase chain reaction detection and identification of Leishmania species in pleural effusions and ascites are important diagnostic tools that should be considered by clinicians evaluating HIV-infected patients from endemic areas of visceral leishmaniasis. The authors review the clinical manifestations, diagnostic and therapeutic aspects of visceral leishmaniasis in immunocompetent and HIV-infected patients.

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“…Peritoneal effusion is an unusual clinical finding in canine leishmaniasis; 5 cases are reported in the literature, but Leishmania organisms were detected in the fluid of only 2 cases 1,4–6 . Based on reports in the literature and the authors' experience, amastigotes may be observed in almost any body tissue or fluid, but they are considered extremely rare in body cavity effusions, urine, synovial fluid, and cerebrospinal fluid in both humans and dogs 7–12 . The presence of Leishmania amastigotes in peritoneal fluid has been rarely described in humans, particularly those co‐infected with human immunodeficiency virus, in which an impaired immune system might play an essential role in dissemination of the parasite 11,12 …”

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Peritoneal effusion from a dog

Dell'Orco¹,

Bertazzolo

Paccioretti³

2009

Veterinary Clinical Pathol

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A 5-year-old, female Italian hound dog was presented with progressive weight loss, anorexia, and lethargy. Physical examination abnormalities included poor body condition, abdominal distension, splenomegaly, and areas of crusty alopecia on the head and limbs. Clinicopathologic abnormalities included mild normocytic normochromic anemia, moderate hyperproteinemia and hyperglobulinemia, mild hypoalbuminemia, and hyponatremia, a mild increase in serum alkaline phosphatase activity, and a moderate to marked increase in beta- and gamma-globulins on serum protein electrophoresis. Abdominal ultrasonography revealed peritoneal effusion. Abdominocentesis yielded approximately 200 mL of serosanguinous, slightly turbid fluid with 2.6 x 10(9) nucleated cells/L, and a protein concentration of 32 g/L. Cytologic specimens of the fluid contained a mixed population of inflammatory cells. Intracytoplasmic inclusions identified as Leishmania sp. amastigotes were observed in numerous macrophages and also free in the background. An ELISA for canine Leishmania sp. antibody was positive. The abdominal effusion resolved within a few days of beginning treatment with meglumine antimoniate and allopurinol. Finding Leishmania amastigotes in peritoneal fluid is rare in canine leishmaniasias and allows an easy, quick diagnosis of the disease.

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Pleural and peritoneal leishmaniasis in an AIDS patient

Cited by 19 publications

References 6 publications

Protozoa in respiratory pathology: a review

Protozoa in respiratory pathology: a review

Microscopy and Polymerase Chain Reaction Detection ofLeishmania chagasiin the Pleural and Ascitic Fluid of a Patient with AIDS: Case Report and Review of Diagnosis and Therapy of Visceral Leishmaniasis

What is your diagnosis? Peritoneal effusion from a dog

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