PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development

Galinha, Carla; Hofhuis, Hugo; Luijten, Marijn; Willemsen, Viola; Blilou, Ikram; Heidstra, Renze; Scheres, Ben

doi:10.1038/nature06206

Cited by 739 publications

(949 citation statements)

References 25 publications

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“…A role for BBM in activating genes involved in secondary cell wall modification seems contradictory, given that secondary cell walls form in cells that have stopped growing. However, in Arabidopsis, BBM is also expressed in the vascular stem cells (procambium) of the embryo and seedling root (Galinha et al 2007), possibly reflecting a role for BBM in vascular tissue development and differentiation.…”

Section: Discussionmentioning

confidence: 99%

BABY BOOM target genes provide diverse entry points into cell proliferation and cell growth pathways

Passarinho¹,

Ketelaar²,

Xing³

et al. 2008

Plant Mol Biol

103

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Ectopic expression of the Brassica napus BABY BOOM (BBM) AP2/ERF transcription factor is sufficient to induce spontaneous cell proliferation leading primarily to somatic embryogenesis, but also to organogenesis and callus formation. We used DNA microarray analysis in combination with a post-translationally regulated BBM:GR protein and cycloheximide to identify target genes that are directly activated by BBM expression in Arabidopsis seedlings. We show that BBM activated the expression of a largely uncharacterized set of genes encoding proteins with potential roles in transcription, cellular signaling, cell wall biosynthesis and targeted protein turnover. A number of the target genes have been shown to be expressed in meristems or to be involved in cell wall modifications associated with dividing/growing cells. One of the BBM target genes encodes an ADF/cofilin protein, ACTIN DEPOLYMERIZING FACTOR9 (ADF9). The consequences of BBM:GR activation on the actin cytoskeleton were followed using the GFP:FIMBRIN ACTIN BINDING DOMAIN2 (GFP:FABD) actin marker. Dexamethasone-mediated BBM:GR activation induced dramatic changes in actin organization resulting in the formation of dense actin networks with high turnover rates, a phenotype that is consistent with cells that are rapidly undergoing cytoplasmic reorganization. Together the data suggest that the BBM transcription factor activates a complex network of developmental pathways associated with cell proliferation and growth.

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Section: Discussionmentioning

confidence: 99%

BABY BOOM target genes provide diverse entry points into cell proliferation and cell growth pathways

Passarinho¹,

Ketelaar²,

Xing³

et al. 2008

Plant Mol Biol

103

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“…Arabidopsis BBM and the other arabidopsis AIL / PLT genes are expressed in the embryo and the root and/or shoot meristems, where they act redundantly to maintain embryo growth and to define and maintain the stem cell niches (Aida et al., 2004; Galinha et al., 2007; Mudunkothge & Krizek, 2012). Overexpression of AIL5 also triggers somatic embryo and adventitious organ formation (Tsuwamoto, Yokoi, & Takahata, 2010).…”

Section: A Network Of Arabidopsis Transcription Factors Controls Somamentioning

confidence: 99%

Section: A Network Of Arabidopsis Transcription Factors Controls Somamentioning

confidence: 99%

“…PLT2 has a role in root meristem maintenance, and plt2 mutant seedlings have shorter roots than wild‐type seedlings (Aida et al., 2004; Galinha et al., 2007). PLT2 functions redundantly with BBM during zygotic embryogenesis: plt2 or bbm mutant embryos do not show abnormal phenotypes, but the plt2 / bbm double mutant arrests at the two‐celled stage (Galinha et al., 2007; Horstman et al., 2015). Despite the lack of zygotic embryo phenotypes in the plt2 single mutant, secondary SE from plt2 immature zygotic embryo explants generates primary and secondary somatic embryos without roots, cotyledons, or shoot apical meristems (Su et al., 2015).…”

Section: A Network Of Arabidopsis Transcription Factors Controls Somamentioning

confidence: 99%

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A transcriptional view on somatic embryogenesis

2017

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Somatic embryogenesis is a form of induced plant cell totipotency where embryos develop from somatic or vegetative cells in the absence of fertilization. Somatic embryogenesis can be induced in vitro by exposing explants to stress or growth regulator treatments. Molecular genetics studies have also shown that ectopic expression of specific embryo‐ and meristem‐expressed transcription factors or loss of certain chromatin‐modifying proteins induces spontaneous somatic embryogenesis. We begin this review with a general description of the major developmental events that define plant somatic embryogenesis and then focus on the transcriptional regulation of this process in the model plant Arabidopsis thaliana (arabidopsis). We describe the different somatic embryogenesis systems developed for arabidopsis and discuss the roles of transcription factors and chromatin modifications in this process. We describe how these somatic embryogenesis factors are interconnected and how their pathways converge at the level of hormones. Furthermore, the similarities between the developmental pathways in hormone‐ and transcription‐factor‐induced tissue culture systems are reviewed in the light of our recent findings on the somatic embryo‐inducing transcription factor BABY BOOM.

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“…Plant hormones such as auxin and cytokinin act as key signaling molecules for regulating this balance. Under auxin signaling, PLETHORAs (PLTs) are known as key regulators of the maintenance of QC nitch cell activity at the root tip [4,5], and the balance between cell proliferation and differentiation. Auxin and cytokinin have been reported to create a transcriptional circuit for regulating PLT activity [6].…”

mentioning

confidence: 99%

MYB30 regulates root cell elongation under abscisic acid signaling

Sakaoka

Mabuchi

Morikami

et al. 2018

Communicative & Integrative Biology

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Reactive oxygen species (ROS) and plant hormones play important roles in regulating plant growth and stress responses as signaling molecules. Abscisic acid (ABA) is known as the key regulator of both abiotic and biotic stress responses. During stress responses, ABA is known to regulate ROS production, indicating that important crosstalk occurs between ROS and ABA signaling. We recently reported that MYB30, an MYB-type transcription factor, regulates root cell elongation under ROS signaling. In this study, we analyzed the molecular interaction between ROS and ABA signal during for root development, which is mediated through MYB30 transcriptional regulation. We showed that MYB30-regulated root cell elongation was mediated by ROS production under ABA signaling. Our findings will provide one piece of evidence of the complex cross talk between ROS and hormone signaling that regulates root development.

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PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development

Cited by 739 publications

References 25 publications

BABY BOOM target genes provide diverse entry points into cell proliferation and cell growth pathways

BABY BOOM target genes provide diverse entry points into cell proliferation and cell growth pathways

A transcriptional view on somatic embryogenesis

MYB30 regulates root cell elongation under abscisic acid signaling

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