Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review

Munğan, Sevdegül; Arslan, Selçuk; Küçüktülü, Eda; Ersöz, Şafak; Çobanoğlu, Bengü

doi:10.1155/2016/8135967

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…Pleomorphic rhabdomyosarcoma (PRMS) is a rare but highly malignant soft tissue cancer, accounting for 3% of soft tissue sarcomas which make up less than 1% of all adult malignancies. [4] Arising from striated muscle cells, PRMS is mostly located in the large muscles of the extremities, particularly the lower limbs and the trunk, such as the abdomen/retroperitoneum, chest, and abdominal wall, [3] although its occurrence around the head and neck area [5] and parenchymal organs, including the testis, [6] uterus, [7] and bladder, [8] has also been reported. In this study, we report a case of PRMS originated from the right shoulder but metastasized to the intestine, which is the first case reported to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic rhabdomyosarcoma metastasis to small intestine causing intussusception

Tong

2018

Medicine

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Rationale:Pleomorphic rhabdomyosarcoma (PRMS) is a rare soft tissue malignancy which is frequently misdiagnosed and associated with metastasis to the lungs, lymph nodes, and bone marrow. Case studies are needed to improve the awareness of the disease and our understanding of it.Patient concerns:In this study, we present a case of a 36-year-old man with a lesion on the right back shoulder. Lesion was confirmed by magnetic resonance imaging (MRI) around the right armpit, subscapularis, deltoid, and infraspinatus muscle, with oozing surrounding soft tissues.Diagnosis:The tumor was diagnosed as PRMS which metastasized to the intestine, where it caused intussusception.Interventions:The patient was treated by complete surgery in combination with neo-adjuvant chemotherapy including ifosfamide and epirubicin.Outcome:The patient remained alive 6 months after the treatment with no recurrence and metastasis.Lesson:PRMS can be aggressive, and surgical treatment in combination with multidrug chemotherapy can be used in the management.

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Section: Discussionmentioning

confidence: 99%

Pleomorphic rhabdomyosarcoma metastasis to small intestine causing intussusception

Tong

2018

Medicine

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“…Pleomorphic rhabdomyosarcoma is a high-grade sarcoma with poor prognosis affecting almost exclusively adults. On histological examination is characterized by a pattern less architecture with no evidence of embryonal or alveolar component and consist of large, bizarre polygonal, round and spindle cells which show skeletal muscle differentiation [10]. Immunohistochemically, desmin, myogenin and MyoD1 are currently considered the most reliable markes, being positive, with a variable intensity and extension, in all the subtypes of rhabdomyosarcoma.…”

Section: Rhabdomyosarcomamentioning

confidence: 99%

Rhabdomyoblasts in Pediatric Tumors: A Review with Emphasis on their Diagnostic Utility

Angelico¹,

Piombino²,

Broggi³

et al. 2017

J Stem Cell Ther Transplant

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SUMMARYRhabdomyosarcoma is a soft tissue pediatric sarcoma composed of cells which show morphological, immunohistochemical and ultrastructural evidence of skeletal muscle differentiation. To date four major subtypes have been recognized: embryonal, alveolar, spindle cell/sclerosing and pleomorphic. All these subtypes are defi ned, at least in part, by the presence of rhabdomyoblasts, i.e. cells with variable shape, densely eosinophilic cytoplasm with occasional cytoplasmic cross-striations and eccentric round nuclei. It must be remembered, however, that several benign and malignant pediatric tumours other than rhabdomyosarcoma may exhibit rhabdomyoblaststic and skeletal muscle differentiation. This review focuses on the most common malignant pediatric neoplasm that may exhibit rhabdomyoblastic differentiation, with an emphasis on the most important clinicopathological and differential diagnostic considerations.

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“…Primary laryngeal sarcomas constitute less than 1% of all malignant laryngeal tumors [ 1 ], and more than 50% of these tumors are fibrosarcomas, followed by osteosarcomas, chondrosarcomas, liposarcomas, leiomyosarcomas, and rhabdomyosarcomas (RMSs) [ 2 ]. RMSs usually involve in skeletal muscle, and thus can be localized in almost any site [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Lü

Ren

et al. 2020

BMC Surg

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Background Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. Case presentation A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. Conclusions Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor.

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Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review

Cited by 10 publications

References 13 publications

Pleomorphic rhabdomyosarcoma metastasis to small intestine causing intussusception

Pleomorphic rhabdomyosarcoma metastasis to small intestine causing intussusception

Rhabdomyoblasts in Pediatric Tumors: A Review with Emphasis on their Diagnostic Utility

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

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