Pleomorphic hyalinizing angiectatic tumor of the male breast: A heretofore unreported occurrence

Tallarigo, Federico; Squillaci, S; Putrino, I; Zizzi, Nicola; Bisceglia, Michele

doi:10.1016/j.prp.2008.07.010

Cited by 21 publications

(21 citation statements)

References 13 publications

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“…1 Fewer than 100 cases have been reported to date; the largest series included 41 cases. 1,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] PHATs mainly occur in adults of both sexes during their fifth or sixth decade of life (range, 10-86 years). Tumor sizes range from 0.3 to 19.7 cm.…”

Section: Pleomorphic Hyalinizing Angiectatic Tumors Of Soft Partsmentioning

confidence: 99%

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The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Liu

Sukov

2018

Archives of Pathology &Amp; Laboratory Medicine

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- Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

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Section: Pleomorphic Hyalinizing Angiectatic Tumors Of Soft Partsmentioning

confidence: 99%

“…The tumors were located in the extremities in 39 patients with tumor sites available. The distribution was feet (21), ankles (5), legs (9), fingers (1), hands (2), and forearms (1). Most of the patients (89.7%) had tumors at the lower extremities, with dorsal foot as the most frequent site.…”

Section: Clinicopathologic Features Of Soft Tissue Tumors With T(1;10mentioning

confidence: 99%

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Liu

Sukov

2018

Archives of Pathology &Amp; Laboratory Medicine

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“…PHAT most commonly presents in adults as a slow‐growing mass involving the lower extremity and may mimic a hematoma clinically. However, other sites of involvement, including the upper extremity and the chest wall, have been documented 10,14,15 . As PHAT tends to be infiltrative, it is prone to local recurrence.…”

Section: Hemosiderotic Fibrolipomatous Tumor and Phatmentioning

confidence: 99%

“…However, other sites of involvement, including the upper extremity and the chest wall, have been documented. 10, 14,15 As PHAT tends to be infiltrative, it is prone to local recurrence. Although local recurrence rates of up to 20% have been observed, metastatic spread has not been reported.…”

Section: Hemosiderotic Fibrolipomatous Tumor and Phatmentioning

confidence: 99%

New or unusual dermatopathology tumors: a review

Lewin

Montgomery

Barrett

2011

Journal of Cutaneous Pathology

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As experience is acquired, there is a constant evolution in both terminology and understanding of various relatively newly described tumors in the realm of dermatopathology. Several mesenchymal tumors of the lower extremity have undergone various changes in nomenclature, molecular discoveries, and histologic grading. Examples include hemosiderotic fibrohistiocytic lipomatous lesion/pleomorphic hyalinizing angiectatic tumor; superficial acral fibromyxoma; and myxoinflammatory fibroblastic sarcoma. Primary cutaneous myoepithelioma is also a relatively newly described entity for which grading and classification continue to evolve. Finally, even our understanding of the classic granular cell tumor has expanded to include a non-neural variant. This article reviews the current nomenclature, emerging concepts, and differential diagnosis of these evolving entities.

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“…Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare mesenchymal tumor of uncertain lineage, first described in 1996 by Smith et al Cellular features of PHAT in cytology specimens have been reported in several papers, in which pleomorphic cells and intranuclear pseudoinclusions were the characteristic findings. However, intracytoplasmic hemosiderin has not been shown conclusively, although fine granular hemosiderin pigments have been described as a conspicuous cytological feature of PHAT .…”

Section: Introductionmentioning

confidence: 99%

A case of a pleomorphic hyalinizing angiectatic tumor of soft parts with intracytoplasmic hemosiderin pigment apparent upon fine‐needle aspiration cytology

Yorita

Ishihara

Tokumitsu

et al. 2014

Diagnostic Cytopathology

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Pleomorphic hyalinizing angiectatic tumors of soft parts are extremely rare low‐grade mesenchymal lesions that frequently occur subcutaneously, especially in the lower extremity. The tumor is histologically characterized by sheets of plump, spindled or rounded cells, and clusters of ectatic blood vessels. It also has a number of previously characterized cytological features such as pleomorphic cells, intranuclear pseudoinclusion, and intracytoplasmic hemosiderin pigments. However, intracytoplasmic hemosiderin has not been carefully evaluated in cytology specimens. Here, we report the case of a 56‐year‐old Japanese man with an encapsulated pleomorphic hyalinizing angiectatic tumor of soft parts that included fine and coarse hemosiderin‐laden tumor cells. The tumor was clinically followed up as a hematoma, but malignant tumors, including malignant melanoma, were suspected because aspiration cytology specimens contained pleomorphic cells with intracytoplasmic brown pigments. The tumor was closely associated with an intratumoral hematoma and a few microscopic satellite lesions. Pleomorphic hyalinizing angiectatic tumor of soft parts should be included in the differential cytological diagnosis of soft tissue tumors if the three cytological features described earlier are present. Enucleation therapy could facilitate local recurrence, as the tumor may have the potential to infiltrate surrounding soft tissue or form satellite lesions. Diagn. Cytopathol. 2015;43:407–411. © 2014 The Authors. Diagnostic Cytopathology Published by Wiley Periodicals, Inc.

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Pleomorphic hyalinizing angiectatic tumor of the male breast: A heretofore unreported occurrence

Cited by 21 publications

References 13 publications

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

New or unusual dermatopathology tumors: a review

A case of a pleomorphic hyalinizing angiectatic tumor of soft parts with intracytoplasmic hemosiderin pigment apparent upon fine‐needle aspiration cytology

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