Pleomorphic carcinoma of the lung: A surgical outcome

Yuki, Tsuyoshi; Sakuma, Takashi; Ohbayashi, Chiho; Yoshimura, Masahiro; Tsubota, Noriaki; Okita, Yutaka; Okada, Morihito

doi:10.1016/j.jtcvs.2007.04.018

Cited by 126 publications

(104 citation statements)

References 11 publications

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“…Since its pathological definition became widely recognized, pleomorphic carcinoma has been diagnosed more frequently: in our study, its frequency was 0.90% (22/2447 cases). In another recent study, it was found to be 1.6% (45/2743) of resected non-small cell lung cancer (NSCLC) [8]. As in previous reports [8][9][10][11][12], most cases in our study were male with a history of smoking; they exhibited symptoms such as hemoptysis and cough.…”

Section: Discussionsupporting

confidence: 75%

“…Recurrence after surgery was frequently observed, and it should be noted that five cases with pN0 disease also relapsed. While Raveglia et al reported that nodal involvement was a determinant prognostic variable of pleomorphic carcinoma of the lung [9], Yuki et al commented that even patients with pN0 disease frequently experienced vascular invasion (57.1%) [8]. We have to keep in mind that pleomorphic carcinoma of the lung has the potential to recur even if the primary lesion is resected at an early stage.…”

Section: Discussionmentioning

confidence: 93%

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Clinical characteristics of pleomorphic carcinoma of the lung

Ito¹,

Oizumi²,

Fukumoto³

et al. 2010

Lung Cancer

104

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Background: Pleomorphic carcinoma of the lung is a malignant epithelial tumor that contains carcinomatous and sarcomatoid components. Due to its rarity, few studies have been reported, and its clinical and pathological characteristics remain unclear.Method: We retrospectively investigated 22 cases of pleomorphic carcinoma of the lung.Results: Fifteen cases were diagnosed by surgical resection, four by autopsy, and three by transbronchial biopsy. Nineteen patients were male and three were female, and their mean age at diagnosis was 68.3 years (± 10.1).Eighteen were current-or ex-smokers with substantial smoking histories (mean 46.4 pack-years). Sixteen patients had symptoms: hemoptysis and cough were commonly seen. Chest computed tomography (CT) findings revealed that the tumors were quite large (mean diameter 45.3 ± 21.9 mm; range 14-110 mm), and 21 tumors were peripherally located. Positron emission tomography with 18-fluorodeoxy-glucose (FDG-PET) was performed in 12 patients, and the Standardized Uptake Value (SUV) tended to be high (9.44 ± 4.98). In the 15 patients who underwent surgical resection, recurrence was common; systemic metastases were also frequently found. Patients who had received surgical 3 treatment with proper follow-up care survived longer than those who did not undergo surgery. Responses to chemotherapy were generally poor, although one patient exhibited partial response to gefitinib.Conclusions: Pulmonary pleomorphic carcinoma has strong malignant potential with frequent distant metastases, as has already been reported. However, this study demonstrated that surgical treatment and appropriate follow-up therapy might result in better prognoses.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 93%

Clinical characteristics of pleomorphic carcinoma of the lung

Ito¹,

Oizumi²,

Fukumoto³

et al. 2010

Lung Cancer

104

View full text Add to dashboard Cite

show abstract

“…As reported previously, pulmonary pleomorphic carcinoma is prone to invasion of the chest wall and mediastinal tissues, 8 and the incidence in our patients was slightly lower than that previously reported. As reported by Ito et al, 4 because the biological behavior of pulmonary pleomorphic carcinoma is highly malignant and even an early tumor may invade the blood vessels, an early pulmonary pleomorphic carcinoma without lymphatic metastasis may recur or metastasize.…”

Section: Discussionsupporting

confidence: 49%

Surgical treatment for pulmonary pleomorphic carcinoma: A retrospective study of 60 patients

Zhong

Fang

et al. 2014

Thoracic Cancer

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Background: Pleomorphic carcinoma is a rare epithelial malignant tumor. Because the clinical characteristics and behavior of the disease remain unclear, we investigated the clinicopathological findings and prognosis of 60 patients with pleomorphic carcinoma. Methods: The clinicopathological characteristics of 60 cases of pulmonary pleomorphic carcinoma identified between 1999 and 2011 were studied. Of these, 55 patients had peripheral disease and five had central disease. The tumor size in all patients was 1-9.5 cm (mean, 5.8 ± 4.5 cm), while 30 had lesions with a diameter larger than 5 cm. All patients underwent pulmonary resection. Results: There were no in-hospital deaths. The three and five year survival rates of all patients were 47.2% and 25.6%, respectively. The three and five year survival rates were 57.3% and 32.5% for N0 patients, and 25.4% and 17.1% for N1-2 patients, respectively. Overall survival was significantly different between the radical resection and incomplete resection groups. Multivariate Cox regression analyses of overall survival for all 60 patients indicated that radical resection (P = 0.041), tumor node metastasis (TNM) stage (P = 0.044), and nodal status (P = 0.029) were significant independent prognostic factors. Conclusion: Pleomorphic carcinoma is a rare type of lung cancer. In our study, pleomorphic carcinoma of the lung was often found as a peripherally located large mass and was associated with a poor prognosis. Radical resection, TNM stage and nodal status were significant independent prognostic factors.

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“…According to several published reports of relatively large patient samples, the five‐year OS rate of patients with PC of the lung after surgery is < 40% 6, 11, 12. Yuki et al .…”

Section: Discussionmentioning

confidence: 99%

Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis

et al. 2018

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BackgroundPleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features and other clinicopathologic factors on survival.MethodsThirty‐five consecutive patients with PC of the lung who underwent surgery between October 2010 and December 2015 were enrolled in this study. The 35 tumors were classified with or without air bronchogram in the tumors, and with or without intratumoral ground glass opacity (GGO) on CT.ResultsAir bronchogram and GGO were detected in 12 (34.3%) and 5 (14.3%) tumors, respectively. Multivariate analysis revealed that air bronchogram was significantly associated with the presence of adenocarcinoma components with lepidic growth patterns (P = 0.005), and predominance of adenocarcinomas (P = 0.026). GGO was significantly associated with the presence of adenocarcinoma component with lepidic growth pattern (P = 0.010). Air bronchogram was an independent favorable prognostic factor for overall survival, whereas GGO did not have a significant effect on survival.ConclusionAir bronchogram observed in PCs of the lung is strongly related with histological components of the tumor and favorable outcome.

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Pleomorphic carcinoma of the lung: A surgical outcome

Cited by 126 publications

References 11 publications

Clinical characteristics of pleomorphic carcinoma of the lung

Clinical characteristics of pleomorphic carcinoma of the lung

Surgical treatment for pulmonary pleomorphic carcinoma: A retrospective study of 60 patients

Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis

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