Pleomorphic Angioleiomyoma

Kawagishi, Naoko; Kashiwagi, Takayuki; Ibe, Masaki; Manabe, Akira; Ishida‐Yamamoto, Akemi; Hashimoto, Yuichi; Iizuka, Hajime

doi:10.1097/00000372-200006000-00012

Cited by 25 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously described cases show bizarre cytologic changes in the background of a cirsoid aneurysm (arteriovenous hemangioma) or capillary‐type hemangioma. Since its original description, a further three cases were reported in the German literature by Kutzner et al 2 Histologically similar vascular lesions with pleomorphic stromal cells probably representing further examples of SH 3 have been described as pleomorphic angioleiomyoma 4–7 cutaneous angiomyolipoma with pleomorphic changes 8 and bizarre angiomyomas of soft tissue 9 . Herein, we describe an additional two cases of this distinctive but poorly recognized entity.…”

mentioning

confidence: 99%

Symplastic hemangioma: report of two cases

2006

View full text Add to dashboard Cite

Symplastic hemangioma is characterized by degenerative atypia of vascular smooth muscle and interstitial cells within a pre-existing vascular lesion with minimal endothelial cell atypia. We describe an additional two cases of this distinctive but poorly recognized entity. On histology, both lesions revealed a cirsoid aneurysm-type appearance with thick-walled and variably dilated blood vessels. The vascular endothelial cells showed mild nuclear hyperchromasia with no multilayering or mitoses. The atypical cells, either located within the vascular smooth muscle wall or within the interstitium, were spindle or epithelioid with varying degrees of hyperchromasia, nuclear enlargement, pleomorphism, and multinucleation. Perivascular hemorrhage, vascular thrombosis, and focal papillary endothelial hyperplasia were uniformly present. The variably fibrous to edematous stroma showed hemosiderin deposits and a mononuclear inflammatory infiltrate. Clusters of adipocytes were present within the superficial dermis. Rare atypical mitoses and occasional bizarre lipoblast-like stromal cells were identified in one tumor. Immunohistochemistry showed focal smooth muscle actin positivity in the pleomorphic cells of the vascular walls. CD68 and CD34 stained occasional stromal cells in the interstitial location. Both the cases showed no recurrence. The bizarre cytologic changes are interpreted as degenerative in nature and probably akin to that observed in ancient schwannoma and uterine symplastic leiomyoma.

show abstract

mentioning

confidence: 99%

Symplastic hemangioma: report of two cases

2006

View full text Add to dashboard Cite

show abstract

“…Kawagishi et al [6] and J. A. Martínez et al [7] have reported cases of pleomorphic angioleiomyomas in the subcutis of lower extremities and scrotum.…”

Section: Discussionmentioning

confidence: 99%

Uterine Angioleiomyoma with Atypia, Raised CA-125 Levels, and Pseudo-Meigs Syndrome: An Alarming Presentation

Thomas

Radhakrishnan

Abraham

et al. 2012

Case Reports in Pathology

View full text Add to dashboard Cite

Angioleiomyomas are benign mesenchymal tumours commonly occurring in the subcutis of extremities. They are typically composed of interlacing fascicles of smooth muscle cells with intersecting vascular channels. Angioleiomyomas of the uterus are rare with only very few case reports available in literature. Herein, we report a case of this rare entity in a 47-year-old woman owing to its highly unusual features of cellular atypia, raised CA-125 levels, and pseudo Meigs syndrome.

show abstract

“…They are solid or capillary, cavernous, and venous. 4,15 A pleomorphic variant has recently been described by Martinez et al 16,17 This is a benign variant containing many bizarre, pleomorphic cells that simulate malignancy. Although the most common form is the solid subtype, which is three times more commonly seen in females and predominately affects the legs, the cavernous type is four times more commonly seen in males and principally affects the upper limb and head.…”

Section: Discussionmentioning

confidence: 99%