Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland

Abstract

We report a case of a pleomorphic adenoma of the lacrimal gland with a prominent clear cell myoepitheliomatous component. An 81-year-old Caucasian woman experienced a 2 month history of right supraorbital swelling and proptosis. Excisional biopsy revealed a multi-component lesion including a stromal component featuring glandular structures made of small epithelioid and spindle cells and a trabecular component with small islands of vacuolated cells, displaced nuclei, and clear cytoplasm. Immunohistochemical analysis revealed strong cytokeratin AE1/3 reactivity and focal smooth muscle actin positivity. The pathologic findings including immunohistochemistry results were consistent with a pleomorphic adenoma with prominent clear cell myoepithelioma component.