Pleomorphic adenoma of the parotid gland: Report of a case with review of literature

A clinicopathological study on morphological pattern and management of parotid tumours: a multicentric experience

“…The mean age of presentation in our study was comparable with other series [9,10]. In contrast to literature, left sided tumours were more frequent and female preponderance was more in our study [11].…”

Descriptive analysis of neoplasias diagnosed as pleomorphic adenoma (PA) that presented at the University of Nigeria Teaching Hospital Ituku-Ozalla Enugu

“…No case of malignant transformation was seen in our study, however, previous researches have shown that long standing pleomorphic adenoma may transform to malignant tumor (carcinoma ex pleomorphic adenoma) in any of the affected gland and this risk is also believed to increase in recurrent cases (Freeman et al, 2003;Rowley et al, 2006;Jain et al, 2015).…”

“…Etiology of pleomorphic adenoma is not clear but studies have suggested that exposure to radiation and Simian virus (S40) may be implicated in causing its development (Jain et al, 2015).…”

“…This finding concurs with similar previous studies which reported high frequencies in the parotid gland as compared to other glands (Everson and Cawson, 1985;Otoh et al, 2005;Nzegwu et al, 2011;Patil et al, 2014). Palate is the most common site for tumors involving the minor salivary glands (Nzegwu et al, 2011;Sahoo et al, 2013;Jain et al, 2015). In contrast, Odukoya (1990) reported higher frequency of pleomorphic adenoma (68.9%) in the minor salivary glands as against 21.1% in the major glands.…”

A Rare Case Report of Pleomorphic Adenoma Arising From Minor Salivary Gland.

“…There is intermixing of the clearly recognizable epithelial component with mucoid, myxoid and chondroid component. 5 Pleomorphic adenoma consists of cells with epithelial and mesenchymal differentiation (mixed tumor).The highly variable morphology of this neoplasm is the result of interplay between these elements. Now it is widely accepted that both epithelial and mesenchymal (myxoid, hyaline, chondroid, osseous) elements often arise from same cell clone, which may be a myoepithelial or ductal reserve cell.…”