Pleomorphic adenoma arising in an incidental midline isthmic thyroid nodule: a case report and review of the literature

Levy, Gillian H.; Marti, Jennifer L.; Cai, Guoping; Kayne, Richard D.; Udelsman, Robert; Hammers, Lynwood; Kowalski, Diane; Prasad, Manju L.

doi:10.1016/j.humpath.2011.02.025

Cited by 14 publications

(5 citation statements)

References 9 publications

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“…(3) Finally, a third possibility as that the MASCs were truly primary to the thyroid gland. Thyroid tumors with morphology similar to their counterparts in the salivary gland are seen occasionally seen in the thyroid; these include pleomorphic adenoma and mucoepidermoid carcinoma [1][2][3][4]27]. An origin on ectopic rests of benign salivary gland tissue may be entertained as they are rarely seen within the thyroid gland [28].…”

Section: Discussionmentioning

confidence: 99%

Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Dettloff

Seethala

Stevens

et al. 2016

Head and Neck Pathol

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Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA). The patients were two females (52 and 55 years-old) and 1 male (74 years-old). The tumors were poorly circumscribed solid white tan nodules involving the thyroid. Histologically, they were invasive and showed solid, microcystic, cribriform, and tubular growth patterns composed of variably bland polygonal eosinophilic cells with vesicular nuclear chromatin and conspicuous nucleoli. All three cases showed metastasis to lymph nodes; one case showed lateral neck involvement. The tumor cells were positive for S100 and mammaglobin. GATA-3 and PAX-8 were positive in 2 cases, one of which only focally so. All three cases were negative for TTF-1 and thyroglobulin. Rearrangement of the ETV6 locus was confirmed in all cases and a diagnosis of MASC rendered for each case. A site of origin distinct from the thyroid gland was not identified, with a median follow up of 24 months. MASC may rarely involve the thyroid gland. The origin of these lesions is unknown; while an origin from ectopic salivary gland-type cells is entertained, a metastatic origin from an occult primary cannot be definitively excluded at this time. Given the histologic (follicular-like microcystic pattern with colloid-like secretions and papillary pattern), immunophenotypic (PAX-8), and even molecular overlap, MASC can be mistaken for papillary thyroid carcinoma and should be considered in the differential diagnosis of a thyroid mass.

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Section: Discussionmentioning

confidence: 99%

Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Dettloff

Seethala

Stevens

et al. 2016

Head and Neck Pathol

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“…As an example, the cumulative incidence for patients with up to 30 years of follow-up after the diagnosis of Hodgkin's lymphoma (HL) was 4.4% for thyroid carcinoma and the mean interval after HL diagnosis was 13.2 years (range 4.0-29.2 years). The most frequent thyroid carcinoma identified in these patients is PTC (Dorffel et al 2000, Levy et al 2012. This pediatric thyroid cancer peak incidence and a 'latency phase' reinforce that a long-term follow-up of patients should be undertaken for survivors of both the Fukushima Daiichi Nuclear Power Plant accident and any cancer during childhood involving radiotherapy to the thorax or head and neck region.…”

Section: Risk Factorsmentioning

confidence: 91%

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Cordioli¹,

Moraes²,

Cury³

et al. 2015

Endocrine-Related Cancer

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Data from the National Cancer Institute and from the literature have disclosed an increasing incidence of thyroid cancer in children, adolescents and adults. Although children and adolescents with thyroid cancer tend to present with more advanced disease than adults, their overall survival rate is excellent; however, there is no clear explanation for the differences observed in the clinicopathological outcomes in these age groups. There has been an ongoing debate regarding whether the clinicopathological differences may be due to the existence of distinct genetic alterations. Efforts have been made to identify these acquired genetic abnormalities that will determine the tumor's biological behavior and ultimately allow molecular prognostication. However, most of the studies have been performed in radiation-exposed pediatric thyroid carcinoma. Therefore, our understanding of the role of these driver mutations in sporadic pediatric differentiated thyroid cancer development is far from complete, and additionally, there is a strong need for studies in both children and adolescents. The aim of this review is to present an extensive literature review with emphasis on the molecular differences between pediatric sporadic and radiation-exposed differentiated thyroid carcinomas and adult population. Key Words" sporadic pediatric papillary thyroid carcinomas " radiation-exposed papillary thyroid carcinomas " RET/PTC

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“…HSGT has been well documented in numerous locations throughout the head and neck have been documented in literature such as the mandible, middle ear, palatine tonsil, gingiva, pituitary gland, cerebellopontine angle, thyroid gland, and the larynx [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] . However, the most common site of predilection is the intraparathyroid lymph nodes [10] .…”

Section: Discussionmentioning

confidence: 99%

A case report of ectopic salivary gland tissue in the tongue base

Soh,

Awan

2023

Radiology Case Reports

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Pleomorphic adenoma arising in an incidental midline isthmic thyroid nodule: a case report and review of the literature

Cited by 14 publications

References 9 publications

Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

A case report of ectopic salivary gland tissue in the tongue base

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