PLEK2 promotes lung adenocarcinoma progression via activating the PI3K/AKT signaling pathway through SPC25 Running title: PLEK2 promotes LUAD via SPC25/PI3K/AKT axis
Wenqian Zhang,
Lei Yu,
Cong Xu
et al.
Abstract:Lung adenocarcinoma (LUAD) is the most common form of NSCLC with poor outcomes and late diagnosis. Previous studies have demonstrated the abnormal expression and promoting role of Pleckstrin-2 (PLEK2) in several tumor types including LUAD, the molecular mechanism of PLEK2 to LUAD progression has not been elucidated clearly. In this study, the expression of PLEK2 in LUAD was analyzed using public available the Cancer Genome Atlas (TCGA) database and further confirmed in human tissue specimens. PLEK2-silencing L… Show more
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