Pleiotropic Microenvironment Remodeling Micelles for Cerebral Ischemia-Reperfusion Injury Therapy by Inhibiting Neuronal Ferroptosis and Glial Overactivation

Li, Chao; Wu, Yuxing; Chen, Qinjun; Luo, Yifan; Liu, Peixin; Zhou, Zheng; Zhao, Zhenhao; Zhang, Tongyu; Su, Boyu; Sun, Tao; Jiang, Chen

doi:10.1021/acsnano.3c05038

Cited by 3 publications

(1 citation statement)

References 55 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, there has been increasing recognition that the tumor microenvironment (TME) is a crucial indicator of cancer survival and progression. − Cancer-associated fibroblasts (CAFs) stand as one of the most important components of TME, − synthesizing fibronectin (FN), various types of collagens, and adhesins to participate in the construction and remodeling of the extracellular matrix (ECM). ,, As an abundant molecule in several types of malignant tumors, FN takes part in a variety of processes that facilitate the progression of cancer cells, by interacting with other cells and ECM molecules. ,− FN-targeting probes have been devised as promising cancer imaging approaches. ,− The Cys-Arg-Glu-Lys-Ala (CREKA) peptide is an effective targeting ligand with high specificity for the fibrin–FN complex in various models, including cancer, myocardial ischemia, and atherosclerosis. − Previous studies show that the contrasts conjugated with CREKA peptide enable excellent detection of breast cancer by magnetic resonance (MR) or NIRF imaging. , …”

Section: Introductionmentioning

confidence: 99%

Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis

Yang,

Huang,

Wang

et al. 2024

Bioconjugate Chem.

View full text Add to dashboard Cite

The prevalence and fatality rates of gastric cancer (GC) remain elevated, with advanced stages presenting a grim prognosis. Noninvasive diagnosis of GC cancer often proves challenging until the disease has progressed to an advanced stage or metastasized. Initially, the level of fibronectin (FN) in cancer-associated fibroblasts (CAFs) of GC was at least 3.7 times higher than that in normal fibroblasts. Herein, two FN-targeting magnetic resonance/near-infrared fluorescence (MR/NIRF) imaging contrast agents were developed to detect GC and peritoneal metastasis noninvasively. The probes CREKA-Cy7-(Gd-DOTA) and CREKA-Cy7-(Gd-DOTA)3 demonstrated significant FN-targeting capability (with dissociation constants of 1.0 and 2.1 mM) and effective MR imaging performance (with proton relaxivity values of 9.66 and 27.44 mM–1 s–1 at 9.4 T, 37 °C). In vivo imaging revealed a high signal-to-noise ratio and successful visualization of GC metastasis using NIRF imaging as well as successful tumor detection in MR imaging. Therefore, this study highlights the potential of FN-targeting probes for GC diagnosis and aids in the advancement of new diagnostic strategies for the clinical detection of GC.

show abstract

Section: Introductionmentioning

confidence: 99%

Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis

Yang,

Huang,

Wang

et al. 2024

Bioconjugate Chem.

View full text Add to dashboard Cite

show abstract

The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke

Delgado‐Martín,

Martínez‐Ruiz

2024

FEBS Letters

View full text Add to dashboard Cite

Ferroptosis is a unique form of cell death that was first described in 2012 and plays a significant role in various diseases, including neurodegenerative conditions. It depends on a dysregulation of cellular iron metabolism, which increases free, redox‐active, iron that can trigger Fenton reactions, generating hydroxyl radicals that damage cells through oxidative stress and lipid peroxidation. Lipid peroxides, resulting mainly from unsaturated fatty acids, damage cells by disrupting membrane integrity and propagating cell death signals. Moreover, lipid peroxide degradation products can further affect cellular components such as DNA, proteins, and amines. In ischemic stroke, where blood flow to the brain is restricted, there is increased iron absorption, oxidative stress, and compromised blood–brain barrier integrity. Imbalances in iron‐transport and ‐storage proteins increase lipid oxidation and contribute to neuronal damage, thus pointing to the possibility of brain cells, especially neurons, dying from ferroptosis. Here, we review the evidence showing a role of ferroptosis in ischemic stroke, both in recent studies directly assessing this type of cell death, as well as in previous studies showing evidence that can now be revisited with our new knowledge on ferroptosis mechanisms. We also review the efforts made to target ferroptosis in ischemic stroke as a possible treatment to mitigate cellular damage and death.

show abstract

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

Xie,

Liao,

Zhang

et al. 2024

Chinese Chemical Letters

View full text Add to dashboard Cite

Pleiotropic Microenvironment Remodeling Micelles for Cerebral Ischemia-Reperfusion Injury Therapy by Inhibiting Neuronal Ferroptosis and Glial Overactivation

Cited by 3 publications

References 55 publications

Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis

Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis

The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

Contact Info

Product

Resources

About