Pleiotropic effects of LDL apheresis

Ramunni, Alfonso; Burzo, Maria; Vernò, Lucia; Brescia, Paola

doi:10.1016/s1567-5688(09)71811-2

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…Low-density lipoprotein apheresis (LDLA) has been applied in patients with peripheral arterial disease (PAD) in Japan as guaranteed therapy by National Health Insurance. LDLA has pleiotropic actions including improvement of blood viscosity, microcirculation, plaque stabilization and regression, and anti-inflammatory effect (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Therefore, combination therapy of BK-EVT and LDLA might bring a beneficial effect, i.e., prevention of early restenosis or reocclusion after BK-EVT.…”

mentioning

confidence: 99%

Beneficial Effect of Endovascular Therapy and Low‐Density Lipoprotein Apheresis Combined Treatment in Hemodialysis Patients With Critical Limb Ischemia due to Below‐Knee Arterial Lesions

et al. 2016

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To assess the clinical benefit of combined treatment of below-knee endovascular therapy (BK-EVT) plus low-density lipoprotein apheresis (LDLA) compared with BK-EVT monotherapy, we retrospectively evaluated the clinical outcome of hemodialysis (HD) patients with critical limb ischemia (CLI) due to isolated BK arterial lesions who underwent BK-EVT or BK-EVT plus short-term LDLA. Between October 2011 and September 2014, 62 HD patients underwent isolated BK-EVT monotherapy (BK-EVT group), and 25 HD patients underwent BK-EVT plus LDLA (BK-EVT + LDLA group). LDLA was started within 1 week after BK-EVT and performed four times in total within next 2 weeks. Major adverse limb events (MALE) including major amputation and re-intervention, and all-cause mortality were examined by Kaplan-Meier method and the log-rank test. Baseline characteristics were not different other than low ABI and low dorsal SPP in BK-EVT + LDLA group. Cumulative MALE-free rate was significantly improved in BK-EVT + LDLA group over the BK-EVT group (72.0% and 45.1% respectively at 30 months after treatment, P = 0.04). All-cause mortality did not differ between the two groups. Major causes of death were heart failure and sepsis in both groups. Short-term LDLA hybrid treatment immediately after BK-EVT might improve the outcome of ischemic limbs after re-vascularization therapy.

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mentioning

confidence: 99%

Beneficial Effect of Endovascular Therapy and Low‐Density Lipoprotein Apheresis Combined Treatment in Hemodialysis Patients With Critical Limb Ischemia due to Below‐Knee Arterial Lesions

et al. 2016

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“…Several other factors may play important roles; for example, endothelial progenitor cells (EPC) derived from the bone marrow might mediate a long-term effect. Therapy with statins, erythropoietin, or estrogens demonstrated an increase in the circulating EPC [17]. Therapeutic apheresis was capable of mobilizing such cells [18].…”

Section: Discussionmentioning

confidence: 99%

“…Removing cytokines, inflammatory mediators, or yet-unknown plasma components might be another method to induce the long-term clinical effects of RHF. Thus, there appears to be a “pleiotropic effect” similar to that described in LDL apheresis [17]. …”

Section: Discussionmentioning

confidence: 99%

Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration: Possible Association with Clinical Changes

Košťál

Bláha

Rencová

et al. 2014

BioMed Research International

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Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin (P < 0.001), a decrease in leukocytes (P < 0.034), and an increase in platelets (P < 0.005). We found a negative correlation between the amount of platelets and their volume (P < 0.001, Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P = 0.003, sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).

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“…A cheaper silica gel column capable of regeneration, (Lipocollect 200; Medicollect, Rimbach, Germany) [58], is being developed. It may be that the achievement of very low levels of LDL-C by LDL apheresis has anti-inflammatory and rheological benefits [59,60] and may reduce oxidization of LDL [61]. The advantage of achieving very low levels of LDL-C by apheresis was shown by Borberg, who reviewed 33 years of treatment of seven HoFH patients using a immunoadsorption system with sufficient capacity to achieve posttreatment values of <2.6 mmol/l (100 mg/dl) or even 1.3 mmol/l (50 mg/dl) [62].…”

Section: Abnormal Lipid Metabolism In Hofhmentioning

confidence: 99%