PLCβ-Mediated Depletion of PIP<sub>2</sub>and ATP-Sensitive K<sup>+</sup>Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus

Lei, Saobo; Boyle, Cody A.; Mastrud, Morgan

doi:10.1523/eneuro.0120-22.2022

Cited by 4 publications

(2 citation statements)

References 98 publications

(120 reference statements)

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“…In addition, AVP is also known to increase the excitability of neurons directly via V 1a receptors as initially shown in neonatal neurons of the facial nucleus in the brainstem (Raggenbass et al, 1991). Recent data also show a direct increase in neuronal excitability by AVP via suppression of K + -channels in the hippocampal formation including subiculum (Lei et al, 2021), CA1 (Hu et al, 2022) and dentate gyrus (Lei et al, 2022) as well as in the medial aspect of the central amygdala (Boyle et al, 2021). V 1a receptors are coupled to Gα q/11 proteins activating phospholipase C β (PLC β ), which hydrolyses phosphatidylinositol 4-5-biphosphate (PIP 2 ) to inositol triphosphate (IP 3 ) and diacylglycerol (DAG).…”

Section: Discussionmentioning

confidence: 98%

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Orav,

Kokinovic,

Teppola

et al. 2024

Preprint

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Birth stress is a strong risk factor for psychiatric disorders and associated with an exaggerated release of the stress hormone arginine vasopressin (AVP) into circulation and in the brain. While it has been shown that AVP promotes firing of GABAergic interneurons leading to suppression of spontaneous perinatal hippocampal network events that suggest a protective function, its effect on developing subcortical networks is not known. Here we tested the effect of AVP on the neonatal dorsal raphe nucleus (DRN) 5-hydroxytryptamine (5-HT, serotonin) system, since early 5-HT homeostasis is critical for the development of cortical brain regions and emotional behaviors. Using in vitro electrophysiological recording techniques, we show that AVP strongly excites neonatal 5-HT neurons via V1A receptors by increasing their excitatory synaptic inputs. Accordingly, AVP also promotes action potential firing through a combination of its effect on glutamatergic synaptic transmission and a direct effect on the excitability of 5-HT neurons. Our in vivo single unit recordings of identified neonatal 5-HT neurons under light urethane anaesthesia revealed two major firing patterns of neonatal 5-HT neurons, tonic regular firing and low frequency oscillations of regular spike trains. We confirmed that AVP also increases firing activity of putative 5-HT neurons in neonatal DRN in vivo. Finally, we show that neonatal DRN contains a sparse vasopressinergic innervation that is strongly sex dependent and originates exclusively from vasopressinergic cell groups in medial amygdala and bed nucleus of stria terminalis (BNST). Our results show, that in contrast to developing cortical networks where AVP promotes inhibition, AVP can also be strongly excitatory in immature subcortical networks such as the DRN 5-HT system. Hyperactivation of the neonatal 5-HT system by AVP during birth stress may impact its own ongoing functional development as well as affect maturation of cortical target regions, which may increase the risk for psychiatric conditions later on.

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Section: Discussionmentioning

confidence: 98%

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Orav,

Kokinovic,

Teppola

et al. 2024

Preprint

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“…The hippocampus, a critical hub of spatial memory formation, seems to be a key point of AVP-mediated memory formation as well. In mice, AVP injections into the ventral hippocampus decreased, while antisera increased forgetting in a Go-No-Go visual discrimination task [ 140 ]. At a cellular level, AVP administration increased the in vitro electrical activity of the dentate gyrus cells (a gate that governs the inflow of information to the hippocampus) [ 141 ].…”

Section: Memory Disturbances Associated With Improper Sleepmentioning

confidence: 99%

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

Török

Várga

Zelena

2022

IJMS

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Normal biological rhythms, including sleep, are very important for a healthy life and their disturbance may induce—among other issues—memory impairment, which is a key problem of many psychiatric pathologies. The major brain center of circadian regulation is the suprachiasmatic nucleus, and vasopressin (AVP), which is one of its main neurotransmitters, also plays a key role in memory formation. In this review paper, we aimed to summarize our knowledge on the vasopressinergic connection between sleep and memory with the help of the AVP-deficient Brattleboro rat strain. These animals have EEG disturbances with reduced sleep and impaired memory-boosting theta oscillation and show memory impairment in parallel. Based upon human and animal data measuring AVP levels, haplotypes, and the administration of AVP or its agonist or antagonist via different routes (subcutaneous, intraperitoneal, intracerebroventricular, or intranasal), V1a receptors (especially of hippocampal origin) were implicated in the sleep-memory interaction. All in all, the presented data confirm the possible connective role of AVP between biological rhythms and memory formation, thus, supporting the importance of AVP in several psychopathological conditions.

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Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons

Kola,

Oraegbuna,

Lei

2024

Molecular and Cellular Neuroscience

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PLCβ-Mediated Depletion of PIP₂and ATP-Sensitive K⁺Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus

Abstract: Title: PLCβ-mediated depletion of PIP 2 and ATP-sensitive K + channels are involved in arginine vasopressin-induced facilitation of neuronal excitability and LTP in the dentate gyrus

Cited by 4 publications

References 98 publications

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons

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PLCβ-Mediated Depletion of PIP2and ATP-Sensitive K+Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus

Abstract: Title: PLCβ-mediated depletion of PIP 2 and ATP-sensitive K + channels are involved in arginine vasopressin-induced facilitation of neuronal excitability and LTP in the dentate gyrus

Cited by 4 publications

References 98 publications

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Arginine vasopressin activates serotonergic neurons in the dorsal raphe nucleus during neonatal developmentin vitroandin vivo

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons

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PLCβ-Mediated Depletion of PIP₂and ATP-Sensitive K⁺Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus