Platyhelminthes

Adell, Teresa; Martín-Durán, José M.; Saló, Emili; Cebrià, Francesc

doi:10.1007/978-3-7091-1871-9_3

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…Whether these morphological commonalities are ancestral or derived in either extant acoels or extant planaria remains unknown. Both acoels and planaria exhibit atypical embryonic development [46,47]; whether these characteristics are ancestral or derived also remains unknown.…”

Section: Planaria Exemplify Basal Bilaterian Morphology and Wbr Capabilitymentioning

confidence: 99%

Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa

Fields

Levin

2020

Communicative & Integrative Biology

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Metazoan body plans combine well-defined primary, secondary, and in many bilaterians, tertiary body axes with structural asymmetries at multiple scales. Despite decades of study, how axisdefining symmetries and system-defining asymmetries co-emerge during both evolution and development remain open questions. Regeneration studies in asexual planaria have demonstrated an array of viable forms with symmetrized and, in some cases, duplicated body axes. We suggest that such forms may point toward an ancestral eumetazoan form with characteristics of both cnidarians and placazoa.

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Section: Planaria Exemplify Basal Bilaterian Morphology and Wbr Capabilitymentioning

confidence: 99%

Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa

Fields

Levin

2020

Communicative & Integrative Biology

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“…The other two are Trematoda and Cestoda. All these are united under the monophyletic Neodermata, whereas the free-living platyhelminths, commonly termed planarians or turbellarians, are distributed in several other subtaxa [1]. There are two subclasses of monogeneans, Monopisthocotylea and Polyopisthocotylea, whose members are commonly ectoparasites of freshwater and marine fishes, but there are also members infecting internal organs of aquatic or semi-aquatic tetrapods.…”

Section: Introductionmentioning

confidence: 99%

De novo transcriptome assembly and identification of G-Protein-Coupled-Receptors (GPCRs) in two species of monogenean parasites of fish

et al. 2022

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Genomic resources for Platyhelminthes of the class Monogenea are scarce, despite the diversity of these parasites, some species of which are highly pathogenic to their fish hosts. This work aimed to generate de novo-assembled transcriptomes of two monogenean species, Scutogyrus longicornis (Dactylogyridae) and Rhabdosynochus viridisi (Diplectanidae), providing a protocol for cDNA library preparation with low input samples used in single cell transcriptomics. This allowed us to work with sub-microgram amounts of total RNA with success. These transcriptomes consist of 25,696 and 47,187 putative proteins, respectively, which were further annotated according to the Swiss-Prot, Pfam, GO, KEGG, and COG databases. The completeness values of these transcriptomes evaluated with BUSCO against Metazoa databases were 54.1% and 73%, respectively, which is in the range of other monogenean species. Among the annotations, a large number of terms related to G-protein-coupled receptors (GPCRs) were found. We identified 109 GPCR-like sequences in R. viridisi, and 102 in S. longicornis, including family members specific for Platyhelminthes. Rhodopsin was the largest family according to GRAFS classification. Two putative melatonin receptors found in S. longicornis represent the first record of this group of proteins in parasitic Platyhelminthes. Forty GPCRs of R. viridisi and 32 of S. longicornis that were absent in Vertebrata might be potential drug targets. The present study provides the first publicly available transcriptomes for monogeneans of the subclass Monopisthocotylea, which can serve as useful genomic datasets for functional genomic research of this important group of parasites.

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“…The class Rhabditophora includes all free-living flatworms, while all members in classes of Monogenea, Trematoda, and Cestoda are parasitic flatworms [39]. The Platyhelminthes or flatworms include more than 20,000 species [40,41].…”

Section: Introductionmentioning

confidence: 99%

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

Esteves¹,

Alvite²

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

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Thanks to the increasing availability of the parasitic Platyhelminthes genomes in recent years, several studies have been directed to the identification of the nuclear receptors set expressed by these organisms. Nevertheless, important gaps in our knowledge remain to be addressed, concerning their mechanism of action, ligands, co-regulator proteins, and DNA binding sequences on target genes. The proposed review chapter will be an account of research into the nuclear receptors field of parasitic Platyhelminthes. Several in vitro effects of host steroid hormones on Taenia and Echinococcus species were observed, however, the classical mammalian estrogen, androgen, or progesterone receptors could not be identified in databases. Nonetheless, novel nuclear receptors and related proteins and genes, are being identified and characterized. The elucidation of their target genes as well as ligands in parasitic Platyhelminthes could allow discovery of new and specific pathways differing from those of their hosts. In this sense, these parasitic proteins seem to be good putative targets of new drugs.

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Platyhelminthes

Cited by 6 publications

References 46 publications

Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa

Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa

De novo transcriptome assembly and identification of G-Protein-Coupled-Receptors (GPCRs) in two species of monogenean parasites of fish

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

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