Platyconic Acid A, a Genuine Triterpenoid Saponin from the Roots of Platycodon grandiflorum

Abstract

A genuine triterpenoid saponin, platyconic acid A (1) was isolated from the roots extract of Platycodon grandiflorum, together with five known saponins: deapioplatycoside E (2), platycoside E (3), platycodin D3 (4), platycodin D2 (5) and platycodin D (6). The structure of 1 was determined on the basis of spectral analysis and chemical evidence.

Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer

“…The column was washed with H 2 O (2 liters) and then eluted with MeOH (5 liters). Polygalacin D2 (PD2) was prepared from the extract of P. grandiflorum for experimental procedures using our method (15).…”

Screening and appraisal for immunological adjuvant-active fractions fromPlatycodon grandiflorumtotal saponins

“…(8) The root of Platycodon grandiflorum A. DC (Campanulaceae) is a well-known Traditional Chinese Medicine used as an expectorant for pulmonary diseases and a remedy for respiratory disorders. As the main bioactive principles of P. grandiflorum, about 40 oleanane-type saponins composed of four type of aglycones, i.e., platycodigenin, platycogenic acid A, platyconic acid A lactone, and polygalacic acid, have been reported so far (9,10) and are regarded as being responsible for the various biological activities such as antitumor, (11)(12)(13)(14) immunomodulatory, (15)(16)(17) hepatoprotective, (18)(19)(20) neuroprotective, (21)(22)(23) antihyperlipidemic, anti-adiposity, (24,25) analgesic, antioxidant, (26) anti hyperglycemic (27) and osteogenic (28) effects.…”

Structure–function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity

“…As the main bioactive principles of P. grandiflorum, about 40 oleananetype saponins, composed of four types of aglycones, i.e., platycodigenin, platycogenic acid A, platyconic acid A lactone, and polygalacic acid, have been reported so far [1][2][3][4][5][6][7][8][9], and are regarded as being responsible for the various biological activities such as antitumor [10][11][12][13][14][15][16], immunomodulatory [17][18][19], hepatoprotective [20][21][22][23][24], neuroprotective [25][26][27], anti-hyperlipidemic, anti-adiposity [28,29], analgesic, antioxidant [30], anti-hyperglycemic [31] and osteogenic [32] effects.…”