Plattenepithelkarzinome des Gesichtes mit neurotropem Wachstum

Ständer, Sonja; Ständer, Hartmut; Kutzner, Heinz; Luger, T A; Metze, Dieter

doi:10.1007/s00105-003-0555-9

Cited by 12 publications

(2 citation statements)

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“…Based on several case reports of transition into squamous cell carcinoma [2] and neutropic metastazation [3][4][5], classification as a variant of squamous cell carcinoma is discussed [6]. While cutaneous squamous cell carcinomas of the head and neck histologically display perineural invasion with a frequency of 0.5-36 % [7], this is an unusual phenomenon in keratoacanthomas occurring in 1-4 % of cases [3,5]. Usually KAs on the head and neck are involved, probably due to the high number of nerve fibers in facial skin [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…While cutaneous squamous cell carcinomas of the head and neck histologically display perineural invasion with a frequency of 0.5–36 %[7], this is an unusual phenomenon in keratoacanthomas occurring in 1–4 % of cases [3, 5]. Usually KAs on the head and neck are involved, probably due to the high number of nerve fibers in facial skin [4, 5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Keratoacanthoma with perineural invasion: An indicator for aggressive behavior?

Basoglu

Metze

Nashan

et al. 2008

J Deutsche Derma Gesell

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Neurotropic invasion of keratoacanthoma (KA) is rare and can easily be missed histologically. A 36-year-old woman developed a KA on the upper lip four weeks after CO(2) laser skin resurfacing; it showed microscopic evidence of perineural invasion. Despite repeated treatment with intralesional methotrexate, the KA recurred after 6 months. She was then treated with ionizing radiation (56 Gy) and has been tumor-free for more than 3 years. Immunohistochemistry showed decreased expression of desmoglein 1 as it is seen in squamous cell carcinomas. In most cases not much importance is attached to perineural invasion which is frequently seen in KA because of the high rate of spontaneous regression. Our case suggests that perineural invasion may be an indicator for aggressive growth of head-and-neck KAs so that histologically-controlled excision is recommended.

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