Platinum nanoparticles confined in metal–organic frameworks as excellent peroxidase-like nanozymes for detection of uric acid

Xia, Mingyuan; Chu, Shushu; Wang, Shuna; Dong, Xuyang; Chen, Chuanxia; Jiang, Yuanyuan; Li, Zhe; Lu, Yizhong

doi:10.1007/s00216-022-04453-1

Cited by 15 publications

(6 citation statements)

References 51 publications

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“…Based on the peroxidase-like activity, KCN-8 may be designed to quantitatively detect H 2 O 2 . Therefore, the detection platform of H 2 O 2 (the KCN-8 method) was constructed with TMB as the chromogenic substrate and KCN-8 as the peroxidase mimic.…”

Section: Resultsmentioning

confidence: 99%

“…Based on the peroxidase-like activity, KCN-8 may be designed to quantitatively detect H 2 O 2 . 61 Therefore, the detection platform of H 2 O 2 (the KCN-8 method) was constructed with TMB as the chromogenic substrate and KCN-8 as the peroxidase mimic. As shown in Figure 6a, as the concentration of H 2 O 2 increases from 0 to 50 mM, there is a gradual increase in the intensity of absorption.…”

Section: Detection Of H 2 Omentioning

confidence: 99%

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Potassium Intercalated into Carbon Nitride Nanosheets as Bifunctional Catalysts for the Simultaneous Photosynthesis and Detection of Hydrogen Peroxide

Li,

He,

Chu

et al. 2023

ACS Appl. Nano Mater.

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The photocatalytic production of hydrogen peroxide (H 2 O 2 ) could provide a green and safe approach for synthesizing H 2 O 2 on demand. However, the common offline methods for the quantitative monitoring of H 2 O 2 concentration are cost-ineffective and not reliable during the in situ photocatalytic process, which is necessary to understand the structure−activity relationship of photocatalysts for H 2 O 2 generation successfully. Herein, we demonstrated a simple and real-time simultaneous photocatalytic production and detection of H 2 O 2 by using potassium (K) ions intercalated into carbon nitride nanosheets (KCN-8). The high crystallinity and K intercalation could synergistically improve the photocatalytic performance of KCN-8. An H 2 O 2 production rate of 158.20 μM mg −1 h −1 was obtained under visible light (λ ≥ 420 nm), which is superior to that of most CN-based photocatalysts. Simultaneously, based on the inherent peroxidase-like property of KCN-8, the colorimetric detection platform of H 2 O 2 was constructed, achieving a precise quantitative detection of H 2 O 2 produced during photocatalysis. Finally, the preparation and detection of H 2 O 2 were realized by KCN-8 nanosheets. This paper not only provides a CN-based catalyst with high photocatalytic performance toward H 2 O 2 production but also demonstrates a cost-effective and real-time method for the quantitative concentration determination of H 2 O 2 .

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Section: Resultsmentioning

confidence: 99%

Section: Detection Of H 2 Omentioning

confidence: 99%

Potassium Intercalated into Carbon Nitride Nanosheets as Bifunctional Catalysts for the Simultaneous Photosynthesis and Detection of Hydrogen Peroxide

Li,

He,

Chu

et al. 2023

ACS Appl. Nano Mater.

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“…26 They have unique multiple channels and cavities, which can serve as coordination environments, similar to natural enzymes. To date, a large variety of MOFs have been applied to simulate the activity of various enzymes, including oxidase, 27,28 peroxidase, 29–31 catalase, 32,33 hydrolase 34,35 and superoxide dismutase, 36,37 etc . Hence, MOF-based nanozymes have extensive application prospects in a variety of fields, such as catalysis, sensing, biochemical analysis, disease diagnosis, gas separation and drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Recent progress of metal–organic framework-based nanozymes with oxidoreductase-like activity

Chi,

Gu,

et al. 2024

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“…To develop a functional POD-based ALP sensor, the essential step is to synthesize an optimized POD nanozyme. Platinum nanoparticles (Pt NPs) exhibit considerable potential in POD catalysis; consequently, they are extensively employed in bioassays and biosensors. − To date, research has continuously explored various Pt-based nanozymes with enhanced catalytic activity by modifying synthesis methods, altering material structures, and reducing the density of stabilizers. − The doping of ruthenium (Ru) has been confirmed as an effective method to enhance the POD activity of Pt nanoparticles (NPs) while simultaneously reducing costs due to the lower price of the Ru element. , Additionally, the type of stabilizer is a key factor in the activity of Pt-derived nanozymes. , However, there is an absence of studies focusing on platinum–ruthenium bimetallic nanoparticles to screen out the optimized stabilizer. Therefore, a systematic investigation into Ru doping and stabilizer types is advantageous for further research to improve the performance of Pt-based POD nanozymes.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Embedded Platinum–Ruthenium Alloy Peroxidase Mimic as a Visual Sensor for “Signal-on” Alkaline Phosphatase Detection

Zhang,

Gong,

Liu

et al. 2024

ACS Appl. Nano Mater.

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Nanozyme-assisted alkaline phosphatase (ALP) assay is a commonly used detection technique. However, this type of sensor faces several challenges, including a "signal-off" detection model, dependence on oxidase mimics, and the need for spectrometers. In this study, by optimizing stabilizers, we obtain chitosan-coated platinum−ruthenium nanoparticles (CS-Pt/Ru NPs) for the first time, which have superior peroxidase (POD) mimic activity. CS-Pt/Ru nanozymes can catalyze phenol oxidation in the presence of 4-aminoantipyrine and hydrogen peroxide to produce an enhanced red color, while phenol can be obtained by ALP-mediated hydrolysis. Thus, ALP activity is quantified by absorbance in a "signal-on" model. This approach demonstrates a remarkably low limit of detection (0.01 U•L −1 ) and a wide linear range (0.03−10 U•L −1 ). In addition, we combine CS-Pt/Ru nanozymes with a hydrogel to form a CS-Pt/Ru@Gel sensor, which enables a visual ALP assay using a smartphone. It can detect ALP activity as low as 0.1 U•L −1 , with a linear range of 0.15−10 U•L −1 . Finally, both Pt/Ru NPs and Pt/Ru@Gel are successfully employed to detect ALP activity in clinical blood samples. Our study develops an excellent hydrogel-supported POD nanozyme system and paves the way for an ALP assay using a "signal-on" and visual model.

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Platinum nanoparticles confined in metal–organic frameworks as excellent peroxidase-like nanozymes for detection of uric acid

Cited by 15 publications

References 51 publications

Potassium Intercalated into Carbon Nitride Nanosheets as Bifunctional Catalysts for the Simultaneous Photosynthesis and Detection of Hydrogen Peroxide

Potassium Intercalated into Carbon Nitride Nanosheets as Bifunctional Catalysts for the Simultaneous Photosynthesis and Detection of Hydrogen Peroxide

Recent progress of metal–organic framework-based nanozymes with oxidoreductase-like activity

Hydrogel-Embedded Platinum–Ruthenium Alloy Peroxidase Mimic as a Visual Sensor for “Signal-on” Alkaline Phosphatase Detection

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