Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

Mishra, Anurag; Mishra, Shivani B.; Manav, Navneet; Kumar, Robin; Sharad,; Chandra, Ramesh; Saluja, Daman; Kaushik, N. K.

doi:10.1016/j.saa.2006.04.038

Cited by 15 publications

(8 citation statements)

References 23 publications

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“…value suggesting some sort of molecular association and/or weak magnetic exchange interactions [32]. The Transition Met Chem electronic spectrum of this complex exhibited bands at 690 and 550 nm attributed, respectively, to d x 2 Ày 2 !…”

Section: Magnetic Moment and Electronic Absorption Spectramentioning

confidence: 90%

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Synthesis, characterization and antioxidant evaluation of metal complexes derived from a dianil ligand with a flexible linkage: anomalous magnetic behavior of the nickel complex

Elhusseiny

Hassan

Hussien

et al. 2015

Transition Met Chem

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The synthesis and characterization of N,N 0 -bis (1-naphthaldimine)-p-oxydianiline, H 2 L, and its Zn(II), Cu(II), Ni(II) and Co(II) complexes are reported. Single crystal X-ray structural analysis showed that H 2 L consists of two tautomers where the central diphenylether unit is flanked by either two ketoamino forms or by one ketoamino and one enolimino form. Physico-chemical data revealed the formation of non-electrolytic [M 2 L 2 (2H 2 O) n ]Á mH 2 O (n and m = 0-2) complexes with variable geometries. The nickel complex exhibited anomalous magnetic behavior compared to literature analogues. This result is attributed to molecular association and suggests the existence of both planar and octahedral forms in a conformational equilibrium. These complexes exhibit thermal stability up to 700°C, except for the Ni(II) complex which degraded to its oxide. Antimicrobial screening data showed that H 2 L had no efficacy against a panel of pathogenic microorganisms, whereas the Ni(II) complex exhibited potency both as an antibacterial and antifungal agent. The properties of the complexes with respect to DPPH radical scavenging, acetyl cholinesterase inhibition and antihemolytic activity were evaluated.

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Section: Magnetic Moment and Electronic Absorption Spectramentioning

confidence: 90%

“…d xy and d x 2 Ày 2 ! d xz;yz transitions in a distorted square planar ligand field [32]. Interestingly, the l eff value of the nickel(II) complex is anomalously at 2.76 B.M.…”

Section: Magnetic Moment and Electronic Absorption Spectramentioning

confidence: 94%

Synthesis, characterization and antioxidant evaluation of metal complexes derived from a dianil ligand with a flexible linkage: anomalous magnetic behavior of the nickel complex

Elhusseiny

Hassan

Hussien

et al. 2015

Transition Met Chem

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“…Coordination chemistry of thiohydrazide, thiodiamine, and thiohydrazone has been reported [7][8][9]. Compounds containing thiol groups are easily converted to the corresponding methyl sulfides (methyl thioethers) and ligands with sulfur and nitrogen donors in their structures are good chelating agents for transition and non-transition metal ions [5][6][7][8][9][10][11]. Coordination of thiohydrazide, thiodiamine, and thiohydrazone compounds with transition metal ions often enhances their activities against microorganisms [9,10].…”

Section: Synthesis Characterization and In Vitro Antibacterial And mentioning

confidence: 99%

Synthesis, characterization, and in vitro antibacterial and antifungal studies of tin(IV) thiohydrazide complexes

Mishra

Tiwari

et al. 2011

Journal of Coordination Chemistry

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Reaction of tin dichloride and tin tetrachloride with cyclohexylamine-N-thiohydrazide (ChaThz) [L 1 ] and 1,3-propanediamine-N-thiohydrazide (PdaThz) [L 2 ] results in [Sn(ChaThz) 2 ] (1), Sn(ChaThz) 2 Cl 2 ] (2), [Sn(PdaThz) 2 ] (3), and [Sn(PdaThz) 2 Cl 2 ] (4), in which the thiohydrazide coordinates to tin through imine nitrogen and thioamide sulfur. The ratio metal : ligand was 1 : 2 for all complexes. The tin(IV) thiohydrazide complexes were characterized by elemental analysis, IR, UV-Vis, 1 H-NMR, 119 Sn NMR, and mass spectral studies. Using the disc diffusion method, the ligands and metal complexes were screened for in vitro antibacterial activities against four pathogenic bacteria, Escherichia coli, Staphylococcus aureus, P. aeruginosa, and Bacillus cereus and for antifungal activities against Aspergillus flavus, A. carbonarius, A. niger, and A. fumigatus. While the tin(IV) complexes exhibited moderate antifungal activities, their parent ligands showed much higher and long-lasting broad spectrum of bioactivity against fungal growth. This was particularly the case for L 1 whose fungal inhibitory activity by the end of the experimental period was comparable and, for the most part, more pronounced than that of AmB. This higher activity of L 1 was maintained specifically against S. Aureus but in general, bacteria were more susceptible to complexes than ligands.

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“…However, these compounds were abandoned due to severe neurotoxicity in the case of ormaplatin and the lack of superior performance in the case of iproplatin (6). Furthermore, numerous new complexes based on the platinum(IV)-ion have been synthesized, and their antitumor activities have been documented (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Platinum (IV) complexes with S-alkyl Derivatives of Thiosalicylic Acid and the Crystal Structure of the S-butyl Derivative of Thiosalicylic Acid

Mijajlović

Nikolić

Tomović

et al. 2017

Serbian Journal of Experimental and Clinical Research

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New platinum(IV)-complexes with S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl-(L1), methyl-(L2), ethyl-(L3), propyl-(L4), butyl-(L5)) have been synthesized and characterized by microanalysis, infrared spectroscopy, and 1 H and 13 C NMR spectroscopy. Th e bidentate S,O ligand precursor, the S-butyl derivative of thiosalicylic acid (S-bu-thiosal), was prepared, and its crystal structure was determined. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water system. S-bu-thiosal crystallized in a P2

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Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

Cited by 15 publications

References 23 publications

Synthesis, characterization and antioxidant evaluation of metal complexes derived from a dianil ligand with a flexible linkage: anomalous magnetic behavior of the nickel complex

Synthesis, characterization and antioxidant evaluation of metal complexes derived from a dianil ligand with a flexible linkage: anomalous magnetic behavior of the nickel complex

Synthesis, characterization, and in vitro antibacterial and antifungal studies of tin(IV) thiohydrazide complexes

Synthesis and Characterization of Platinum (IV) complexes with S-alkyl Derivatives of Thiosalicylic Acid and the Crystal Structure of the S-butyl Derivative of Thiosalicylic Acid

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