Platinum(II) complexes with carbazates and hydrazides: Synthesis, spectral characterization, computational modeling, and biological studies

Abstract

Platinum(II) complexes with carbazates and hydrazydes: Synthesis, spectral characterization, computational modeling, and biological studies, Polyhedron (2015), doi: http://dx. AbstractThis work reports on the synthesis and characterization of complexes of the type cis-[Pt(L) 2 X 2 ], where L = 4-methoxybenzylcarbazate (4-MC), benzyl carbazate (BC), 4-fluorophenoxyacetic acid hydrazide (4-FH), 3-methoxybenzoic acid hydrazide (3-MH), ethyl carbazate (EC), tert-butyl carbazate (TC), (4-hydroxy-phenyl)-acetic acid hydrazide (4-HH), and X = Cl -or I -.The structures of the platinum(II) complexes were optimized and theoretical data show good agreement with the experimental results, suggesting that the ligands are coordinated via the NH 2 groups. The cytotoxic activity of three representative compounds was evaluated in a chronic myelogenous leukemia cell line and health cell line from mouse (L929). The platinum complex with 4-fluorophenoxyacetic acid hydrazide was more active than the free ligand and carboplatin therefore it may be considered a promising antitumor agent. In addition, the platinum complexes with 4-methoxybenzylcarbazate (4-MC) and benzyl carbazate (BC) exhibited good activity. On the other hand, microbiological assays against Mycobacterium tuberculosis showed that all complexes and organic compounds are not very active.

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

“…Two intense bands between 1085 and 1045 cm − 1 are attributable to the presence of two unidentate perchlorate ions [37]. Hydrazides show characteristic absorptions between 3332 and 3150 cm − 1 which are attributable to the NH 2 and NH groups [22,23]. In all complexes studied, the bands originating from NH 2 group showed considerable shift as compared to the free ligands.…”

“…This class of compounds has the ability to readily coordinate to many transition metals. Therefore, several hydrazide complexes have been synthesized and characterized [22,23]. Some of these compounds exhibit remarkable biological properties, mainly antimycobacterial and antitumoral [24][25][26][27][28][29][30][31][32].…”

A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis‐[Pt(PPh3)2(L1‐O,S)]PF6 (L1‐O,S = N,N‐Morpholine‐N′‐benzoylthiourea)

“…According to the data from Table , the complex showed a moderate inhibitory action against mycobacterium tuberculosis (H37Rv ATCC 27294) when compared to the reference drug (ethambutol). Also, the observed MIC values suggest that the complex is active against the tumor cells MDA‐MB 231 (6.92 ± 0.60) and DU‐145 (3.09 ± 1.1), although lower than other platinum(II) and palladium(II) complexes previously obtained by us , , …”

“…Furthermore, the effect of the intramolecular Pt ··· H–C interaction on the donor phosphine ligand has been analyzed by the closely inspection of the infrared spectra in the C–H stretching vibration. This is a crowded region because of the many C–H bonds present in the complex, but a very strong band is observed at 3057 cm –1 , which can be assigned to the C–H stretching mode in the phosphine group , . It is accepted that anagostic interactions is mostly electrostatic in character, in line with the strong C–H absorption observed in the infrared spectrum.…”

Síntese, caracterização e estudos biológicos envolvendo complexos de paládio(II) e rutênio(II) com hidrazidas e carbazatos

“…Bandas de estiramento e deformação angular C=C do anel aromático dos ligantes, com exceção do EC e TC, foram localizadas entre 1530 -1505 cm -1 e entre 694-825 cm -1 , respectivamente. Além disso, o espectro do ligante 4-FH revela uma banda referente ao estiramento C-F em 1245 cm -1 , (PAVIA, 2010 (RODRIGUES et al, 2015). Além disso, os espectros dos complexos revelam uma nova banda entre 516-621 cm -1 que podem ser atribuídas ao  Pd-N .…”