Platinum(II) complexes of 8-quinolylmethylphosphonates: Synthesis, characterization and antitumour activity

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

“…In the spectra of 1-4, the ion [(M + Na) -NaX -HX] + that is the parent ion of the nonpalladium containing species is formed easily by elimination of two halides and has intensities in range 24%-64% (Table S1). For other complexes, fragments analogous to [(M + Na) -NaX -HX] + were assigned as (9)(10)(11)(12). To produce these species, at least one more fragmentation step is required comparing to the chelate complexes.…”

“…The derivatives containing pyridine and quinoline heterocyclic rings are also very attractive metalcomplexing agents that might form biologically important metal complexes. Thus, a number of aminophosphonate complexes of platinum group metals have been found to possess remarkable antitumor activity in vitro [7][8][9][10][11]. With this regard, there is a steadily growing interest for search of new biologically active aminophosphonate derivatives and their metal complexes, especially esters of α-aminophosphonic acids.…”

“…With this regard, there is a steadily growing interest for search of new biologically active aminophosphonate derivatives and their metal complexes, especially esters of α-aminophosphonic acids. Our research program in this area has been directed to the synthesis and characterization of new biologically active palladium(II) and platinum(II) complexes with dialkyl and monoalkyl esters of phosphonic acids derived from quinoline and aniline [8,9,[12][13][14]. It was found that different types of investigated complexes, such as molecular dihalide adducts with trans and cis configuration, mononuclear and binuclear metallocyclic and ion-pair halide salt complexes, have shown good cell growth inhibitory effects.…”

N–H···O=P hydrogen-bonded dimers as the main structural motif of aminophosphonate diesters

“…These compounds are widely used as broad-spectrum antiviral agents [6] and for treatment of bone diseases [7], while some complexes of platinum group metals exhibit remarkable antitumor activity [8][9][10][11]. a-Aminophosphonates act as isosteres of naturally occurring a-amino acids [3,12] and phosphates [12,13] and can be used as inhibitors of various enzymes and in metabolism regulation [1][2][3][4]13].…”