Platinum(II) Bisisocyanide Cyclometallated Complexes: Synthesis, Structure, Photophysical Properties, and Mechanochromic Behavior

Katkova, Svetlana A.; Sokolova, Elina V.; Kinzhalov, Mikhail A.

doi:10.1134/s1070363223010073

Cited by 1 publication

(1 citation statement)

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“…Although these complexes share certain characteristics, they exhibit unique electrochemical properties, with the carbon-platinum bond demonstrating notably higher strength compared to the nitrogen-nitrogen bond. These complexes represent a distinct addition to the existing literature, as previous research on cyclometallated complexes has primarily focused on applications such as catalysis, organic light-emitting diodes (OLEDs), electrical conductors, optoelectronic devices, and molecular materials, with only a handful of examples pertaining to medicinal applications [15][16][17][18][19][20][21][22][23][24][25]. [11][12][13] and the comparable cyclometallated counterpart (C L ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterisation of Fluorescent Novel Pt(II) Cyclometallated Complexes with Anticancer Activity

McGhie

Sakoff

Gilbert

et al. 2023

IJMS

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Cancer poses a significant threat to global health and new treatments are required to improve the prognosis for patients. Previously, unconventional platinum complexes designed to incorporate polypyridyl ligands paired with diaminocyclohexane have demonstrated anticancer activity in KRAS mutated cells, previously thought to be undruggable and have cytotoxicity values up to 100 times better than cisplatin. In this work, these complexes were used as inspiration to design six novel cyclometallated examples, whose fluorescence could be exploited to better understand the mechanism of action of these kinds of platinum drugs. The cytotoxicity results revealed that these cyclometallated complexes (CMCs) have significantly different activity compared to the complexes that inspired them; they are as cytotoxic as cisplatin and have much higher selectivity indices in breast cancer cell lines (MCF10A/MCF-7). Complexes 1b, 2a, and 3b all had very high selectivity indexes compared to previous Pt(II) complexes. This prompted further investigation into their DNA binding properties, which revealed that they had good affinity to ctDNA, especially CMCs 1a and 3b. Their inherent fluorescence was successfully utilised in the calculation of their DNA binding affinity and could be useful in future work.

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