Platinum concentration in human tumors of head and neck, uterine cervix, and breast following treatment with cisplatin

Hecquet, B; Vennin, P; Fournier, Charles; Lefèbvre, Jean Louis; Caty, Armelle; Bonneterre, J.; Adenis, L; Demaille, A

doi:10.1007/bf00263908

Cited by 16 publications

(8 citation statements)

References 5 publications

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“…Platinum concentrations have been measured in biopsies of tumours of the head and neck after intravenous and intra-arterial infusions of cisplatin. The platinum concentrations found were in the range 0.71 to 7.9 ,ug g tumour (Gouyette et al, 1986;Hecquet et al, 1985).…”

Section: Introductionmentioning

confidence: 92%

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Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Holding¹,

Lindup²,

Bowdler³

et al. 1991

Brit J Clinical Pharma

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Section: Introductionmentioning

confidence: 92%

“…The platinum concentrations found Correspondence: Dr W. E. Lindup, Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147,Liverpool,L69 3BX were in the range 0.71 to 7.9 ,ug g tumour (Gouyette et al, 1986;Hecquet et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Holding¹,

Lindup²,

Bowdler³

et al. 1991

Brit J Clinical Pharma

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“…In order to quantify the activity content in the tumours, liver and kidneys in the patients, phantom studies were performed. A known activity of 191 Pt was filled in spheres with diameters of 15,20,25 and 30 mm simulating tumours, a MIRD (16) liver phantom and a kidney phantom consisting of two cylinders, 50 mm in diameter and 62 mm in length. The 'organs' were inserted in a water-filled, elliptical thorax phantom (adult MIRD (16)).…”

Section: Imaging and Quantitati6e Measurementsmentioning

confidence: 99%

Gamma Camera Imaging of Platinum in Tumours and Tissues of Patients after Administration of¹⁹¹Pt-Cisplatin

Areberg

1999

Acta Oncologica

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The aim of this study was to visualize non-invasively the uptake of platinum in tumours and tissues after treatment with cisplatin. 191Pt-cisplatin was synthesized from 191PtCl4 with rigorous pharmaceutical quality control. The uptake of platinum by both tumorous and healthy tissues was studied by gamma camera imaging in 14 patients, 5 of whom showed a clear uptake of platinum in regions corresponding to known tumour sites. Maximum concentrations of platinum in the tumours were on average 4.9+/-1.0 microg/g, when normalized to an administered amount of 180 mg cisplatin. In all the patients, the liver was the organ that showed the highest uptake. Platinum uptake was also seen in the spleen, gall bladder, gastrointestinal tract, bladder, kidneys, ureter, neck and mediastinum and urogenital region. By using in-house production of 191Pt-cisplatin, it was possible to monitor the uptake of platinum in tumorous tissues and healthy organs.

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“…Cisplatin (cis-diamminedichloroplatinum) was developed by Rosenberg (36) in the 1960s and was initially used in the treatment of head and neck, uterine and bladder cancers (37). Cisplatin is one of the most important drugs for the treatment of gastric cancer; it has demonstrated a high positive-response rate in the treatment of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line

et al. 2017

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Therapies for patients with scirrhous gastric cancer remain ineffective. Current treatments for gastric cancer based on systemic therapy, such as the combination of S-1 with cisplatin or docetaxel, show good clinical response rates. S-1 plus cisplatin is the standard treatment for HER2-negative advanced scirrhous gastric cancer in Japan. In spite of recent advances in the treatment of gastric cancer, a standard chemotherapy regimen is yet to be established for scirrhous gastric cancer. To develop new therapeutic approaches based on characteristic biological features of cancer cells, we examined the mechanisms underlying the cytotoxicity of anticancer drugs and reactive oxygen species (ROS) toward a human scirrhous cancer cell line, HSC-39, in vitro. Anticancer drugs such as 5-fluorouracil (5-FU), adriamycin (ADR) and irinotecan (CPT-11), as well as ROS, were previously shown to have important cytotoxic effects on these tumor cells. We demonstrated that 5-FU effectively induced apoptosis in HSC-39 cells in a dose‑dependent manner, while ADR and CPT-11 induced necrosis and/or aponecrosis. 5-FU effectively inhibited WST-1 decrease in the MTT viability assay, even at low doses where little LDH release was observed, while ADR and CPT-11 only inhibited WST-1 decrease at high doses where LDH release was induced. Moreover, HSC-39 cells showed high sensitivity to H2O2 and NOC-18, but less sensitivity to other ROS, suggesting a link between cell damage and membrane permeability changes induced by H2O2 and NOC-18 or related oxygen radical species such as OH· or ·O2. These results suggest that combination treatment of chemotherapeutics with a fluoropyrimidine such as 5-FU is effective chemotherapy for scirrhous gastric cancer.

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Platinum concentration in human tumors of head and neck, uterine cervix, and breast following treatment with cisplatin

Cited by 16 publications

References 5 publications

Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Gamma Camera Imaging of Platinum in Tumours and Tissues of Patients after Administration of¹⁹¹Pt-Cisplatin

Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line

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Platinum concentration in human tumors of head and neck, uterine cervix, and breast following treatment with cisplatin

Cited by 16 publications

References 5 publications

Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck.

Gamma Camera Imaging of Platinum in Tumours and Tissues of Patients after Administration of191Pt-Cisplatin

Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line

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Gamma Camera Imaging of Platinum in Tumours and Tissues of Patients after Administration of¹⁹¹Pt-Cisplatin