Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

Yang, Yang; Zhu, Delan; Liu, Ying; Jiang, Bing; Jiang, Wei; Yan, Xiyun; Fan, Kelong

doi:10.1039/d0nr02800b

Cited by 109 publications

(74 citation statements)

References 35 publications

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“…In addition to CAT, many metal‐based nanoenzymes including Pt (Equation (1)), [ 99,134–135 ] Mn (Equation (2)), [ 111,136–137 ] prussian blue (PB) (Equation (1)), [ 103,138–139 ] and Fe (Equations (3)–(7)) [ 105,108–109,110–141 ] based nanozymes possess CAT‐like catalytic capabilities for tumor reoxygenation. Some of these mechanisms are written below (Equations 1–7)

2 {normalH}_{2} {normalO}_{2} \overset{Pt or PB}{\to} 2 {normalH}_{2} O + {normalO}_{2}

{MnO}_{2} + {normalH}_{2} {normalO}_{2} + 2 {normalH}^{+} \to {Mn}^{2 +} + {normalO}_{2} + 2 {normalH}_{2} O

{Fe}^{2 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{3 +} +^{•} OH + {OH}^{-}

{Fe}^{3 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{2 +} + {HO}_{2}^{•} + {normalH}^{+}

{Fe}^{3 +} + {HO}_{2}

…”

Section: In Situ O2 Generationmentioning

confidence: 99%

Conquering the Hypoxia Limitation for Photodynamic Therapy

et al. 2021

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Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due to the hypoxic nature characteristic of many solid tumors, PDT is frequently limited in therapeutic effect. Moreover, the consumption of O2 during PDT may further aggravate the tumor hypoxic condition, which promotes tumor proliferation, metastasis, and invasion resulting in poor prognosis of treatment. Therefore, numerous efforts have been made to increase the O2 content in tumor with the goal of enhancing PDT efficacy. Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O2 to tumor directly, 2) generating O2 in situ, 3) reducing tumor cellular O2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia‐inducible factor 1 (HIF‐1) signaling pathway to relieve tumor hypoxia. Additionally, the O2‐independent Type‐I PDT is also discussed as an alternative strategy. By reviewing recent progress, it is hoped that this review will provide innovative perspectives in new nanomaterials designed to combat hypoxia and avoid the associated limitation of PDT.

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2 {normalH}_{2} {normalO}_{2} \overset{Pt or PB}{\to} 2 {normalH}_{2} O + {normalO}_{2}

{MnO}_{2} + {normalH}_{2} {normalO}_{2} + 2 {normalH}^{+} \to {Mn}^{2 +} + {normalO}_{2} + 2 {normalH}_{2} O

{Fe}^{2 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{3 +} +^{•} OH + {OH}^{-}

{Fe}^{3 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{2 +} + {HO}_{2}^{•} + {normalH}^{+}

{Fe}^{3 +} + {HO}_{2}

…”

Section: In Situ O2 Generationmentioning

confidence: 99%

Conquering the Hypoxia Limitation for Photodynamic Therapy

et al. 2021

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“…They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH). [13][14][15][16][17] Owing to the temporal and spatial management over the localization of the sound or light, the ROS can be generated precisely in the tumor tissues instead of normal tissue, thus minimizing the side effects. [18][19][20] The unique quantity of deep tissue penetration and little side The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment.…”

mentioning

confidence: 99%

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

Liu

et al. 2021

Advanced Materials

105

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clinical cancer treatments. [1] Though some conventional methods, such as surgery, radiotherapy, and chemotherapy, have been used to treat malignant melanoma in clinics, these methods have exhibited limited treatment efficiencies in inhibiting tumor growth, leading to low patient survival rates. Therefore, more creative and efficient ways are urgently needed to overcome these clinical bottlenecks; for instance, gene therapy, photodynamic therapy (PDT), photothermal therapy, sonodynamic therapy (SDT), and immunotherapy. [2][3][4][5][6] However, due to the diversity, complexity, and heterogeneity of the MM tumor, [7] mono-modal therapy has been found to show limited treatment efficiency for MM tumors. Consequently, searching for integrated therapeutic strategies with multi-modal therapeutics is highly necessary to achieve remarkable antitumor effects. [8][9][10][11][12] The SDT and PDT have been selected as potential clinical methods for treating a wide range of superficial and localized tumors. They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH). [13][14][15][16][17] Owing to the temporal and spatial management over the localization of the sound or light, the ROS can be generated precisely in the tumor tissues instead of normal tissue, thus minimizing the side effects. [18][19][20] The unique quantity of deep tissue penetration and little side The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment. Recently, multi-modal therapeutics with enhanced antitumor efficiencies have attracted increasing attention. However, designing a nanotherapeutic platform with uniform morphology in nanoscale that integrates with efficient chem-/sono-/phototrimodal tumor therapies is still a great challenge. Here, new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies are designed. The atomic morphology and chemical structure analysis prove that the biocatalyst consists of atomic Pd-N coordination networks with a Pd-N 2 -Cl 2 catalytic center. The characterization of peroxidase-like catalytic activities displays that the Pd-Pta/Por can generate abundant •OH radicals for chemodynamic therapies. The ultrasound irradiation or laser excitation can significantly boost the catalytic production of 1 O 2 by the porphyrin-based sono-/photosensitizers to achieve combined sono-/photodynamic therapies. The superior catalytic production of •OH is further verified by density functional theory calculation. Finally, the corresponding in vitro and in vivo experiments have demonstrated their synergistic chem-/sono-/photo-trimodal antitumor efficacies. It is believed that this study provides new promising single-atom-coordinated polymeric networks with highly efficient biocatalytic sites and synergistic trimodal therapeutic effects, which may inspire many new findings in rea...

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“…The Pt NPs [ 442 ] with CAT-mimicking capacity and Ru–Te hollow nanorods [ 436 ] with OXD, POD-, CAT- and SOD-type activity both acted as carriers and relieved TME hypoxia to enhance cancer PDT/PTT effect. Different from most nanozyme-based synergistic therapy, Yang et al [ 443 ] covered Pt-carbon integrated nanozymes as PSs via one-step reduction. Under NIR light lasering, the nanozymes provided brilliant photosensitivity and photothermal effect.…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

Abstract:
Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process.

Cited by 109 publications

References 35 publications

Conquering the Hypoxia Limitation for Photodynamic Therapy

Conquering the Hypoxia Limitation for Photodynamic Therapy

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

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Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

Abstract: Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process.

Cited by 109 publications

References 35 publications

Conquering the Hypoxia Limitation for Photodynamic Therapy

Conquering the Hypoxia Limitation for Photodynamic Therapy

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

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Product

Resources

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Abstract:
Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process.