Platinacycloalkane complexes containing [P,N] bidentate ligands: synthesis and decomposition studies

Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Smith, Gregory S.; Slootweg, J. Chris; Lammertsma, Koop

doi:10.1039/c3dt52798k

Cited by 7 publications

(5 citation statements)

References 65 publications

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“…It is known that cod-linked platinum(II) complexes exhibit an unusually high acute toxicity against HT-29 and MCF-7 cells. 74 Despite these findings, there have been, to the best of our knowledge, no further experiments with derivatized cod ligands until now.…”

Section: ■ Results and Discussionmentioning

confidence: 98%

“…Several studies have shown high cytotoxicity of platinum complexes with organic ligands, such as perfluoro or chloro ligands, against different cell lines. It is known that cod-linked platinum(II) complexes exhibit an unusually high acute toxicity against HT-29 and MCF-7 cells . Despite these findings, there have been, to the best of our knowledge, no further experiments with derivatized cod ligands until now.…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

et al. 2014

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The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC 3 F 7 , iC 3 F 7 , nC 8 F 17 , Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear ( 1 H, 13 C, 19 F, 195 Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.

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Section: ■ Results and Discussionmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

et al. 2014

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“…Nevertheless, in addition to several examples of seven-membered stannacycles or phosphacycles, , Jolly et al reported in 1997 that chromacycloheptane 105 could be synthesized utilizing 1,6-di(chloromagnesium)hexane with a supporting ligand (Scheme ). It was reported that d 8 transition-metal dichlorides supported by COD or phosphorus ligands could react with 1,6- or even 1,8- di- Grignard reagents to afford the corresponding metallacycloheptanes or metallacyclononanes . However, compared to their 1,4- or 1,5-analogues, much fewer examples have been realized for saturated 1,6- or longer dicarbanion compounds to synthesize heterocycles.…”

Section: 6- or Longer Dicarbanion Compoundsmentioning

confidence: 99%

Dicarbanion Compounds: The Bridge between Organometallic Reagents and Mononuclear Heterocycles

Chai

Zhang

2022

Organometallics

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Dicarbanion compounds, namely organo-bi-metallics in which two metal atoms are separated by all-carbon backbones, are of great importance in organometallic chemistry for not only the interest in the structure but also the wide application in synthesis, especially of mononuclear heterocycles. The synthetic methods and reactivities of dicarbanion compounds highly depend on the type of metals as well as the structure of backbones. For metal types, while there are examples of other metals, lithium and magnesium play important roles in the chemistry of dicarbanion compounds. For the backbone structure, different unsaturated bonds in the backbones result in different rigidities and orientations of carbon−metal bonds and thus have a great impact on the reactivity of dicarbanion compounds. Herein, a general review of the preparation, structure, and reactivity of dicarbanion compounds with different metals and backbones are presented, mainly focusing on the dicarbanion compounds that have been or may potentially be employed in mononuclear heterocycle synthesis. Heterocycles mentioned in this review are mostly metallacycles because of the limitation of synthetic methods.

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“…To investigate whether ligands bearing an imine group, as shown in Scheme 1, also form photophysically interesting complexes, the synthesis of a copper(I) iodide complex was undertaken with R = benzyl. The ligand with R = Bn is not new but has already been used for the complexation of Re(I) [33], Fe [34], Co [35], Pd [36][37][38][39][40], Rh [41], Ru [42], Au [9,43], Pt [9,44], Ir [45], and Cu [46].…”

Section: Introductionmentioning

confidence: 99%