As we face a worldwide pandemic, environmental disasters, social unrest, and economic uncertainty, each individual's mental as well as physical health is critical to workplace productivity. Employee physical and mental health are now recognized as significant concerns for companies around the world. Employee well-being is no longer a benefit in human resource management, but rather a strategic requirement. Workers' well-being and health are critical components of building a positive workplace culture, and human resources (HR) is responsible for prioritizing these areas. This chapter dives into identifying the role that firms must play in guaranteeing their staff's physical and mental health, examining the issues they confront, and providing insights into successful human resource management practices. More specifically, in this chapter, the authors will look at HR's role in worker's well-being and mental health, the advantages of putting staff wellness first, and the critical tactics HR can use to build a workforce that is productive and healthy.