Platelets: Still a Therapeutical Target for Haemostatic Disorders

Geraldo, Reinaldo Barros; Sathler, P.C; Lourenço, André Luiz; Saito, Max Seidy; Cabral, Lúcio Mendes; Rampelotto, Pabulo Henrique; Castro, Helena C.

doi:10.3390/ijms151017901

Cited by 12 publications

(5 citation statements)

References 115 publications

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“…Human thrombopoiesis is finely tuned, since the number and function of circulating platelets are essential to maintain hemostasis [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Indeed, while excessive platelet release (thrombocytosis) and activation (platelet hyperreactivity) are usually associated with a higher thrombotic risk [ 25 ], reduced platelet counts (thrombocytopenia) and altered platelets function, due to inherited or acquired defects [ 26 ], might compromise wound healing, resulting in an increased risk of bleeding and hemorragic disorders [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

ROS in Platelet Biology: Functional Aspects and Methodological Insights

Masselli

Pozzi

Vaccarezza

et al. 2020

IJMS

111

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Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism. Indeed, several signaling pathways have been demonstrated to induce ROS production by NAPDH oxidase (NOX) and mitochondria, upon platelet activation. Platelet-derived ROS, in turn, boost further ROS production and consequent platelet activation, adhesion and recruitment in an auto-amplifying loop. This vicious circle results in a platelet procoagulant phenotype and apoptosis, both accounting for the high thrombotic risk in oxidative stress-related diseases. This review sought to elucidate molecular mechanisms underlying ROS production upon platelet activation and the effects of an altered redox balance on platelet function, focusing on the main advances that have been made in platelet redox biology. Furthermore, given the increasing interest in this field, we also describe the up-to-date methods for detecting platelets, ROS and the platelet bioenergetic profile, which have been proposed as potential disease biomarkers.

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Section: Introductionmentioning

confidence: 99%

ROS in Platelet Biology: Functional Aspects and Methodological Insights

Masselli

Pozzi

Vaccarezza

et al. 2020

IJMS

111

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“…The site of platelet reserve is the spleen and the senescent platelets undergo phagocytosis in the spleen and liver. The zones of platelet have been explained in Figure 1 (6).…”

Section: Platelet Kineticsmentioning

confidence: 99%

Platelet lysate for COVID-19 pneumonia—a newer adjunctive therapeutic avenue

Jeyaraman¹,

Muthu²,

Khanna³

et al. 2021

Stem Cell Investig

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The linchpin for COVID-19 pathogenesis is the severe inflammatory process in the respiratory tract wherein the accumulation of excessive cytokines paves the way for a series of systemic hemodynamic alterations and mortality. The mortality rate is higher in individuals with co-morbidities and advancing age. The absence of a specific therapy is responsible for this uncontrolled spread and the significant mortality. This renders potential insight for considering biologics as a plausible option to repair and regenerate the affected lung tissue and pulverize the causative organism. The plausible role of megakaryocytes against invading microbes was not clearly understood. Platelet lysate is an acellular product consisting of regenerative molecules released from a cluster of platelets. It attenuates the changes caused by immune reactions in allogenic utility with the introduction of growth factors, cytokines, and proteins at supraphysiologic levels and thereby serves as a regenerative immunomodulatory agent to combat COVID-19. This platelet lysate can be used in nebulized form for such acute respiratory distress conditions in COVID-19 elderly patients. Platelet lysate may emerge as a pivotal player provided investigations pace up in this context. Here, we discuss how the platelet lysate can plausibly perquisite to relegate COVID-19. Undertaking prospective randomized controlled trials to prove its efficacy is the need of the hour in this pandemic scenario.

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“…Pathological conditions occur because of nonspecific activity of platelets, stimulation of agonist secretion, and platelet aggregation in atheromatous plaques; these conditions decrease the number of platelets in circulation and cause ischemia. 85 The mechanism by which platelets engulf small molecules is different from conventional phagocytosis, in which an engulfed substance is metabolized. Compared with other carriers, encapsulated substances in the platelet remain intact, and are thus referred to as covercytes.…”

Section: Platelets As Drug Delivery Systemsmentioning

confidence: 99%

Recent advancements in erythrocytes, platelets, and albumin as delivery systems

Xu¹,

Wang

Wang³

et al. 2016

OTT

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In the past few years, nanomaterial-based drug delivery systems have been applied to enhance the efficacy of therapeutics and to alleviate negative effects through the controlled delivery of targeting and releasing agents. However, few drug carriers can achieve high targeting efficacy, even when targeting modalities and surface markers are introduced. Immunological problems have also limited their wide applications. Biological drug delivery systems, such as erythrocytes, platelets, and albumin, have been extensively investigated because of their unique properties. In this review, erythrocytes, platelets, and albumin are described as efficient drug delivery systems. Their properties, applications, advantages, and limitations in disease treatment are explained. This review confirms that these systems can be used to facilitate a specific, biocompatible, and smart drug delivery.

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Platelets: Still a Therapeutical Target for Haemostatic Disorders

Cited by 12 publications

References 115 publications

ROS in Platelet Biology: Functional Aspects and Methodological Insights

ROS in Platelet Biology: Functional Aspects and Methodological Insights

Platelet lysate for COVID-19 pneumonia—a newer adjunctive therapeutic avenue

Recent advancements in erythrocytes, platelets, and albumin as delivery systems

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Platelets: Still a Therapeutical Target for Haemostatic Disorders

Cited by 12 publications

References 115 publications

ROS in Platelet Biology: Functional Aspects and Methodological Insights

ROS in Platelet Biology: Functional Aspects and Methodological Insights

Platelet lysate for COVID-19 pneumonia—a newer adjunctive therapeutic avenue

Recent advancements in erythrocytes, platelets, and&nbsp;albumin as delivery systems

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Product

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Recent advancements in erythrocytes, platelets, and albumin as delivery systems