Platelets in Neurological Disorders

Canobbio, Ilaria; Guidetti, Gianni Francesco; Torti, Mauro

doi:10.1007/978-3-319-47462-5_35

Cited by 8 publications

(8 citation statements)

References 207 publications

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“…They reported non-significant genetic correlations with both Plt and MPV in the largest PD case-control GWAS metaanalysis carried out so far (involving ∼ 56,300 PD cases and ∼ 1.4 million controls) (15). Of note, in spite of the previous implication of PDW in neurodegenerative disorders (4,(9)(10)(11) and, more recently, in comorbid disorders like major depression (16,17), this parameter has never been investigated with reference to PD risk at the genetic level.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is important to identify potential biomarkers that are easy to measure and that could predict the incident risk of such diseases, e.g., circulating biomarkers ( 3 ). Among these, platelets have received increasing attention ( 4 – 6 ), and their link with neurodegenerative disorders has long been hypothesized ( 7 ). Indeed, platelets are considered “circulating mirrors of neurons” and share many similarities with neural cells ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, platelets are considered “circulating mirrors of neurons” and share many similarities with neural cells ( 8 ). These include the molecular machinery that controls the secretory system ( 5 ), patterns of reciprocal interactions, and the metabolism of different neurotransmitters like serotonin and dopamine, but also of neurologically important proteins like the Amyloid Precursor Protein ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

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Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders

et al. 2020

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Neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) suffer from the lack of risk-predictive circulating biomarkers, and clinical diagnosis occurs only when symptoms are evident. Among potential biomarkers, platelet parameters have been associated with both disorders. However, these associations have been scarcely investigated at the genetic level. Here, we tested genome-wide coheritability based on common genetic variants between platelet parameters and PD/AD risk, through Linkage Disequilibrium Score Regression. This revealed a significant genetic correlation between platelet distribution width (PDW), an index of platelet size variability, and PD risk (r g [SE] = 0.080 [0.034]; p = 0.019), which was confirmed by a summarysummary polygenic score analysis, where PDW explained a small but significant proportion PD risk (<1%). AD risk showed no significant correlations, although a negative trend was observed with PDW (rg [SE] =-0.088 [0.053]; p=0.096), in line with previous epidemiological reports. These findings suggest the existence of limited shared genetic bases between PDW and PD and warrant further investigations to clarify the genes involved in this relation. Additionally, they suggest that the association between platelet parameters and AD risk is more environmental in nature, prompting an investigation into which factors may influence these traits.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders

et al. 2020

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“…Patients with complex neurological and neuropsychiatric disorders such as schizophrenia, Parkinson and Alzheimer’s diseases have already been described with altered platelet function several decades ago [ 1 , 2 , 3 , 4 , 5 , 6 ]. Since then, numerous studies have given better insight into those early observations, by deciphering the cellular, molecular and functional similarities between platelets and neurons [ 7 , 8 , 9 , 10 , 11 ], and they have set the basis for the use of blood platelets as a working model to study several neurological diseases [ 3 , 8 , 9 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

Izzi

Tirozzi

Cerletti

et al. 2020

IJMS

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Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.

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“…Among these mechanisms, the platelet activation is one of the most attractive, seeing platelets as a potential mirror of the brain (dys)-function [ 13 ]. Indeed, even though platelet and neurons are basically different cells, they share common characteristics in subcellular organization [ 14 ] and in protein composition [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ], representing as consequence an alternative tool to investigate neuronal dysfunction as well as a peripheral tracer of the onset and progression of brain-related pathologies.…”

Section: Introductionmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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Platelets in Neurological Disorders

Cited by 8 publications

References 207 publications

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders

Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

Depression and Cardiovascular Disease: The Viewpoint of Platelets

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