Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy

Mallah, Haneen; Ball, Somedeb; Sekhon, Jasmine; Parmar, Kanak; Nugent, Kenneth

doi:10.1016/j.rmed.2020.106098

Cited by 35 publications

(25 citation statements)

References 43 publications

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“…Among many mitochondrial diseases, the COX dysfunction complex is considered to be the most serious. Recent studies have shown that the lung is vital for platelet biogenesis ( Mallah et al, 2020 ). Previous studies have confirmed that cigarette smoking could induce platelet aggregation and reduce the ability of the platelet mitochondrial electron transport system.…”

Section: Discussionmentioning

confidence: 99%

Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects

Sun

Zhang

et al. 2022

Front. Mol. Biosci.

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Air pollution exposure is now considered a growing concern for global public health. RNA or DNA methylation changes caused by air pollution may be related to the development of cardiovascular disease. To investigate the early biomarkers of air pollution exposure, a panel study of eight college students recorded after a business trip from Qingdao to Shijiazhuang and back to Qingdao was performed in this work. The concentration of PM2.5, PM10, SO2, NO2, and CO in Shijiazhuang was higher than that in Qingdao during the study period. The platelet count was positively correlated with air pollutants of 0–6 day moving averages (βPM2.5 = 88.90; βPM10 = 61.83; βSO2 = 41.13; βNO2 = 57.70; βCO = 62.99, respectively, for an IQR increased). Additionally, internal dose biomarkers 2-OHNa, 1-OHNa, 2-OHFlu, 2,3-OHPhe, and ∑PAHs were also significantly associated with platelet count in participants. Furthermore, PM2.5 and PM10 are positively linked with methylation of one CpG site at platelet mitochondrial gene CO2 (PM2.5 = 0.47; PM10 = 0.25, respectively, for an IQR increase). Both platelet counts and methylation levels returned to their pre-exposure levels after leaving the highly contaminated area. In short, this study investigated the relationship between platelet properties and air pollution exposure, revealing that short-term exposure to air pollution might increase the risk of thrombosis. Our research suggests that platelet count and mitochondrial DNA methylation of mtCO2 site 2 in platelets from healthy adults may be the novel biomarker for acute exposure to air pollution.

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Section: Discussionmentioning

confidence: 99%

Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects

Sun

Zhang

et al. 2022

Front. Mol. Biosci.

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“…The thrombo-inflammatory impact of platelets in respiratory diseases is well investigated and characterized in acute infectious pulmonary diseases inflicted by Streptococcus pneumoniae [ 147 , 148 ], Pseudomonas aeruginosa [ 149 ], influenza A virus H1N1 (A/H1N1) [ 150 , 151 ], severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 85 , 86 , 87 ]. Platelets also effectively contribute to chronic respiratory diseases like asthma [ 152 , 153 ], chronic obstructive pulmonary disease (COPD) [ 154 ] and aspirin-exacerbated respiratory disease (AERD) [ 155 ]. Platelet-derived inflammatory mediators, platelet interaction with inflammatory cells of the innate (monocyte, neutrophils) or the adaptive immune wing play a decisive role in disease progression and severity [ 156 ].…”

Section: Therapeutic Implication Of Ackr3/cxcr7 In Platelet-associated Cardiovascular Diseasementioning

confidence: 99%

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

Chatterjee

2022

Cells

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The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7. Platelets express CXCR4, ACKR3/CXCR7, and are a vital source of CXCL12/SDF-1α themselves. In recent years, a regulatory impact of the CXCL12-CXCR4-CXCR7 axis on platelet biogenesis, i.e., megakaryopoiesis, thrombotic and thrombo-inflammatory actions have been revealed through experimental and clinical studies. Platelet surface expression of ACKR3/CXCR7 is significantly enhanced following myocardial infarction (MI) in acute coronary syndrome (ACS) patients, and is also associated with improved functional recovery and prognosis. The therapeutic implications of ACKR3/CXCR7 in myocardial regeneration and improved recovery following an ischemic episode, are well documented. Cardiomyocytes, cardiac-fibroblasts, endothelial lining of the blood vessels perfusing the heart, besides infiltrating platelets and monocytes, all express ACKR3/CXCR7. This review recapitulates ligand induced differential trafficking of platelet CXCR4-ACKR3/CXCR7 affecting their surface availability, and in regulating thrombo-inflammatory platelet functions and survival through CXCR4 or ACKR3/CXCR7. It emphasizes the pro-thrombotic influence of CXCL12/SDF-1α exerted through CXCR4, as opposed to the anti-thrombotic impact of ACKR3/CXCR7. Offering an innovative translational perspective, this review also discusses the advantages and challenges of utilizing ACKR3/CXCR7 as a potential anti-thrombotic strategy in platelet-associated cardiovascular disorders, particularly in coronary artery disease (CAD) patients post-MI.

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“…Moreover, aspirin was associated with a significantly improved quality of life and lower odds of dyspnoea development in COPD patients, and lower risk of in-hospital death and need for invasive mechanical ventilation in patients hospitalised for acute exacerbation. Finally, a meta-analysis suggested that antiplatelet treatment might significantly reduce all-cause mortality in COPD patients (reviewed in [150]). These clinical studies do not allow the discrimination of the mechanisms involved in the improvement of COPD patients.…”

Section: Antiplatelet Therapy In Chronic Respiratory Diseasesmentioning

confidence: 99%

Platelets: a potential role in chronic respiratory diseases?

et al. 2021

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Platelets are small anucleate cells known for their role in haemostasis and thrombosis. In recent years, an increasing number of observations have suggested that platelets are also immune cells and key modulators of immunity. They express different receptors and molecules that allow them to respond to pathogens, and to interact with other immune cells. Platelets were linked to the pathogenesis of some inflammatory disorders including respiratory diseases such as asthma and idiopathic pulmonary fibrosis. Here, we discuss the involvement of platelets in different immune responses, and we focus on their potential role in various chronic lung diseases.

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Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy

Cited by 35 publications

References 43 publications

Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects

Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

Platelets: a potential role in chronic respiratory diseases?

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