Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis

Olumuyiwa-Akeredolu, Oore-ofe O.; Pagé, Martin; Soma, Prashilla; Pretorius, Etheresia

doi:10.1038/s41584-019-0187-9

Cited by 72 publications

(71 citation statements)

References 207 publications

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“…Platelets are small anucleate cell fragments circulating in the blood, originally derived from megakaryocytes in the bone marrow. While the relevance of platelet activation for blood clot formation after vascular injury is well established, more exploratory research has shown that platelets contribute to the (patho)physiological processes important for cancer, inflammation, infection, and neurological diseases . The parallel between platelets and serotonergic neurons was drawn in the early 1970s .…”

Section: Parallels Between Platelets and Neuronsmentioning

confidence: 99%

“…While the relevance of platelet activation for blood clot formation after vascular injury is well established, more exploratory research has shown that platelets contribute to the (patho)physiological processes important for cancer, inflammation, infection, and neurological diseases. [13][14][15][16] The parallel between platelets and serotonergic neurons was drawn in the early 1970s. 17,18 The link with neurological disorders still mostly relates to the similarities between the platelet release reaction of stored agonists following stimulation and the neurotransmitter release following an action potential in a neuron ( Figure 1).…”

Section: Parallels Between Platelets and Neuronsmentioning

confidence: 99%

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Blood platelet research in autism spectrum disorders: In search of biomarkers

Padmakumar

Raes

Geet

et al. 2019

Research and Practice in Thrombosis and Haemostasis

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Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for autism. None of them have delivered the holy grail that represents a reproducible, quantifiable, and sensitive biomarker. Though blood platelets are mainly known to prevent bleeding, they also play pivotal roles in cancer, inflammation, and neurological disorders. Platelets could serve as a peripheral biomarker or cellular model for autism as they share common biological and molecular characteristics with neurons. In particular, platelet‐dense granules contain neurotransmitters such as serotonin and gamma‐aminobutyric acid. Molecular players controlling granule formation and secretion are similarly regulated in platelets and neurons. The major platelet integrin receptor αIIbβ3 has recently been linked to ASD as a regulator of serotonin transport. Though many studies revealed associations between platelet markers and ASD, there is an important knowledge gap in linking these markers with autism and explaining the altered platelet phenotypes detected in autism patients. The present review enumerates studies of different biomarkers detected in ASD using platelets and highlights the future needs to bring this research to the next level and advance our understanding of this complex disorder.

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Section: Parallels Between Platelets and Neuronsmentioning

confidence: 99%

Section: Parallels Between Platelets and Neuronsmentioning

confidence: 99%

Blood platelet research in autism spectrum disorders: In search of biomarkers

Padmakumar

Raes

Geet

et al. 2019

Research and Practice in Thrombosis and Haemostasis

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“…(L) A representative clot after purified fibrinogen was simultaneously exposed to a combination of P. gingivalis LPS (10ng.L -1 ) and RgpA (500ng.L -1 ) . When inflammatory molecules are upregulated in circulation, they either cause direct endothelial damage (by binding to receptors on endothelial cells), or they may act as ligands that bind directly to platelet membrane receptors (Olumuyiwa-Akeredolu et al, 2019). When these inflammatory molecules disrupt endothelial cell structure, the endothelial cells release collagen and von Willebrand (vWF).…”

Section: The Presence Of Bacterial Inflammagens In Parkinson's Diseasementioning

confidence: 99%

“…In PD, changes in the normal clotting of blood have been described (Sato et al, 2003;Rosenbaum et al, 2013;Pretorius et al, 2014;Infante et al, 2016;de Waal et al, 2018;Pretorius et al, 2018c). Most of these circulating inflammatory biomarkers act as ligands to receptors on platelets (Olumuyiwa-Akeredolu et al, 2019), resulting in downstream signaling events with accompanying platelet hyperactivity and aggregation. RBCs also become eryptotic (programmed cell death in RBCs) due to ligand binding and oxidative stress (Pretorius et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…For this and other diseases (Potgieter et al, 2015;Kell and Kenny, 2016;Pretorius et al, 2016a;Pretorius et al, 2017a;de Waal et al, 2018;Kell and Pretorius, 2018a;Kell and Pretorius, 2018b) we have brought together evidence that a chief cause may be (dormant) microbes that upon stimulation, especially with unliganded iron (Kell, 2009), can briefly replicate and shed potent (and well known) inflammagens such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) Kell and Pretorius, 2018a). These are well-known ligands for receptors such as Toll-like receptor 4 (TLR4) and can thus stimulate inflammation, as observed through a variety of inflammatory cytokines (Olumuyiwa-Akeredolu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens

Adams

Nunes

Pagé

et al. 2019

Preprint

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Parkinson's disease (PD) is a well-known neurodegenerative disease. Recently, the role of gingipains from Porphyromonas gingivalis was implicated in Alzheimer's disease. Here we present evidence of systemic inflammation, accompanied by hypercoagulation; we also show that ginipains from P. gingivalis and its LPS may foster abnormal clotting, and that ginipains are present in PD blood, and thus that ginipain's action on blood may be relevant to PD pathology. Bloods from both PD and healthy blood samples were analysed using thromboelastography (TEG), confocal and electron microscopies, and for cytokine and other circulating biomarkers. We also probed PD and healthy plasma clots with a polyclonal antibody for the bacterial protease, gingipain R1, from P. gingivalis. Low concentrations of recombinant gingipain R1 were also added to purified fluorescent fibrinogen. TEG, fibrin(ogen) amyloid formation and platelet ultrastructure analysis confirmed profound hypercoagulation, while the biomarker analysis confirmed significantly increased levels of circulating proinflammatory cytokines. We provide evidence for the presence of the protease, gingipain R1 in PD blood, implicating inflammatory microbial cell wall products in PD.

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Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Han

Pang

2021

Adv Funct Materials

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Rheumatoid arthritis (RA) affects the joints and extra-articular organs and poses a significant health care problem in the modern era. Although current standard treatment modalities successfully control RA flares, no curative treatment modality for RA has been developed. Nanomedicines have addressed the drug side effects and limited efficacy of RA treatment. However, synthetic nanoparticles (NPs) can be toxic and induce immune responses in vivo, posing a risk of further RA progression. Biomimetic nanodrug delivery systems have the potential to improve the biocompatibility of synthetic NPs and the stability and targeting of pharmaceuticals in vivo. For many immune-related diseases with a complex pathogenesis and that involve a large number of different cell types, biomimetic nanodelivery systems can reduce the immunogenicity of NPs. Furthermore, some bioinspired strategies can mimic certain components of the pathological process, allowing for a more precise drug delivery and effective disease control via the carriers. This article highlights recent research on biomimetic nanodelivery systems for the treatment of RA and categorizes the design methodologies for various targets and carriers.

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Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis

Cited by 72 publications

References 207 publications

Blood platelet research in autism spectrum disorders: In search of biomarkers

Blood platelet research in autism spectrum disorders: In search of biomarkers

Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

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