Platelets as Peripheral Model of Glutamate-Related Excitotoxicity in Parkinson’s Disease

Ferrarese, Carlo; Bianchi, G.; Bugiani, Marianna; Cogliati, Tiziana; Frigo, M.; Passoni, Davide; Pecora, N.; Piolti, Roberto; Pozzi, Clara; Tortorella, Rachele; Frattola, L.

doi:10.1007/978-1-4899-0209-2_9

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the dietetic origin, which has been proposed for them, does not satisfy wholly the criteria of a 'classic' endocoid [13,14]. In the same vein, DBI, which is the precursor of a family of negative allosteric ligands and has been found in the cerebrospinal fluid of neuropsychiatric patients [6,[15][16][17][18][19], has a low affinity for central BDZ receptors and appears to interact more specifically with peripheral BDZ receptors, whose role in anxiety is debatable [20],…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine Binding Inhibitory Activity: New Supportive Findings on Its Presence in Psychiatric Patients and Further Biochemical Analyses

Marazziti

Giannaccini²,

Martini³

et al. 1996

Neuropsychobiology

View full text Add to dashboard Cite

The authors investigated the presence of a serum activity inhibiting the specific binding of ³H-flunitrazepam (which labels the central benzodiazepine receptors) (BBIA) in patients with different psychiatric disorders and analyzed it by means of high performance liquid chromatography (HPLC) analysis. The results showed that the lowest activity was present in healthy controls who were not different from patients with schizophrenia and obsessive-compulsive disorder. On the contrary, the BBIA values of these 3 groups of patients were significantly lower than those found in patients with bipolar disorder in various phases (depressive, mixed or manic), in unipolar depressives and in patients with panic and delusional disorders. The HPLC analysis of the serum extracts revealed the presence of 3 peaks of activity which were differently distributed in the patients and in the healthy controls, peak 3 being totally absent in the last group and mainly represented in bipolar depressives. The GABA ratio values showed that peaks 1 and 2 behave as agonists while peak 3 behaves as an inverse agonist. The mass fragmentography of the different peaks is in progress.

show abstract