Platelets and platelet-derived vesicles as an innovative cellular and subcellular platform for managing multiple sclerosis

Mehdi-Alamdarlou, Sanaz; Ahmadi, Fatemeh; Shahbazi, Mohammad‐Ali; Azadi, Amir; Ashrafi, Hajar

doi:10.1007/s11033-023-08322-7

Cited by 5 publications

(4 citation statements)

References 85 publications

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“…They do so by affecting the activation and/or migration of leukocytes, endothelial cells, hematopoietic progenitor cells, and stem cells (34). Elevated expressions of CXCL9 and CXCL12 have been observed in various autoimmune diseases, including IBD, rheumatoid arthritis(35), Behcet's disease(36), and multiple sclerosis (37). These elevated expressions are positively correlated with disease activity and/or severity, which support the ndings of the study.…”

Section: Discussionsupporting

confidence: 66%

Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of Inflammatory bowel disease

liu,

Li,

Gao

et al. 2023

Preprint

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Objective The literature has previously reported the associations between inflammatory bowel disease (IBD) and certain inflammatory cytokines, such as CRP, IL-1, and TNFα. To additionally evaluate the causal relationships between 41 inflammatory cytokines and IBD, a Mendelian randomization (MR) study was conducted. Methods The two-sample MR investigation utilized data from three large publicly available genome-wide association studies (GWAS) on IBD, ulcerative colitis (UC), and Crohn's disease (CD) genetic variants. Additionally, inflammatory cytokine data from a GWAS meta-analysis, including 8,293 healthy individuals, were incorporated into the study. Causal relationships between exposures and outcomes were predominantly determined utilizing inverse variance-weighted methods. To evaluate the heterogeneity, pleiotropy, and stability of these genetic variants, the MR-Egger intercept test, Cochran's Q test, and leave-one-out sensitivity analysis were conducted. Results The findings revealed that IL13 was linked to an elevated risk of IBD, UC, and CD, while MIF demonstrated a correlation with an elevated risk of CD. Conversely, TNF-related apoptosis-inducing ligand (TRAIL) was linked to a decreased risk of IBD and UC. Additionally, reverse MR analyses revealed that IBD was correlated with elevated levels of Monokine Induced by Gamma Interferon (MIG) and Stromal Cell-Derived Factor-1α (SDF1A), while UC showed an association with elevated levels of MIG and IL10. The CD was linked to elevated levels of stem cell factor (SCF) and decreased levels of TNF-β. Conclusion In the MR study, three upstream regulatory factors and five downstream regulatory factors were identified for IBD and its subtypes, providing avenues for developing new therapies for IBD.

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Section: Discussionsupporting

confidence: 66%

Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of Inflammatory bowel disease

liu,

Li,

Gao

et al. 2023

Preprint

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“…PL-EVs are the most numerous EVs in the blood [77,78] and have shown immunomodulatory effects in endothelial cells, T cells and monocytes [79,80]. An increase in the number of PL-EVs and the presence of PL-EVs-Ig immunocomplexes (IC) has been reported in inflammatory conditions [81][82][83][84][85][86]. In systemic lupus erythematosus (SLE), PL-EVs showed increased levels of complement components and decreased TGF-β1 and lysosomalassociated membrane protein 1 (LAMP-1) [84,87].…”

Section: Plateletsmentioning

confidence: 99%

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Delgado Dolset,

Pablo‐Torres,

Contreras

et al. 2024

Clin Experimental Allergy

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Persistent and unresolved inflammation is a common underlying factor observed in several and seemingly unrelated human diseases, including cardiovascular and neurodegenerative diseases. Particularly, in atopic conditions, acute inflammatory responses such as those triggered by insect venom, food or drug allergies possess also a life‐threatening potential. However, respiratory allergies predominantly exhibit late immune responses associated with chronic inflammation, that can eventually progress into a severe phenotype displaying similar features as those observed in other chronic inflammatory diseases, as is the case of uncontrolled severe asthma. This review aims to explore the different facets and systems involved in chronic allergic inflammation, including processes such as tissue remodelling and immune cell dysregulation, as well as genetic, metabolic and microbiota alterations, which are common to other inflammatory conditions. Our goal here was to deepen on the understanding of an entangled disease as is chronic allergic inflammation and expose potential avenues for the development of better diagnostic and intervention strategies.

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“…PMPs represent the most abundant MPs in human circulation [ 12 , 13 , 14 ]. Many studies have recognized the role of PMPs in hemostasis, thrombosis, cardiovascular disease, autoimmune diseases and cancer [ 15 , 16 , 17 , 18 , 19 ]. However, the role of PMPs in autoimmune diseases has not yet been reviewed in detail.…”

Section: Overview Of Pmpsmentioning

confidence: 99%

Platelet-Derived Microparticles and Autoimmune Diseases

Wang

2023

IJMS

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Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the integrity of blood vessels. When platelets are activated, they can perform related tasks by secreting platelet-derived microparticles that contain lipids, proteins, nucleic acids, and even organelles. There are differences in the circulating platelet levels in many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren’s syndrome. In this paper, the latest findings in the research field of platelet-derived microparticles are reviewed, including the potential pathogenesis of platelet-derived microparticles in various types of immune diseases, their potential as related markers, and for monitoring the progress and prognosis of disease treatment are expounded.

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Platelets and platelet-derived vesicles as an innovative cellular and subcellular platform for managing multiple sclerosis

Cited by 5 publications

References 85 publications

Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of Inflammatory bowel disease

Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of Inflammatory bowel disease

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Platelet-Derived Microparticles and Autoimmune Diseases

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