Platelets and Granulocytes, in Particular the Neutrophils, Form Important Compartments for Circulating Vascular Endothelial Growth Factor

Kusumanto, Yoka H.; Dam, Wendy; Hospers, Geke A.P.; Meijer, Coby; Mulder, Nanno

doi:10.1023/b:agen.0000029415.62384.ba

Cited by 483 publications

(379 citation statements)

References 12 publications

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“…On the other hand, high neutrophil counts in blood causes an increase in vascular endothelial growth factor (VEGF) emission which plays an important role in tumor progression and angiogenesis. Accordingly; increased tumor recurrence, poor prognosis and decreased survival were seen (Kusumanto et al, 2003;Fondevila et al, 2004) For this reason, similar studies have been conducted on NLR in urological malignancies in recent years . It has been found that neutrophilia and lymphocytopenia were associated with poor prognosis in metastatic renal tumors (Ohno et al, 2010).…”

Section: Discussionmentioning

confidence: 91%

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Gazel¹,

Taştemur²,

Açıkgöz³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aim of this study was to research the importance of the neutrophil to lymphocyte ratio (NLR) in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far. Materials and Methods: The data of 175 patients who were diagnosed with localised prostate cancer and underwent retropubic radical prostatectomy was retrospectively examined. Patient pre-operative hemogram parameters of neutrophil count, lymphocyte count and NLR were assessed. The patients whose PSAs were too low to measure after radical prostatectomy in their follow-ups, and then had PSAs of 0,2 ng/mL were considered as patients with PSA recurrence. Patients with recurrence made up Group A and patients without recurrence made up Group B. Results: In terms of the power of NLR value in distinguishing recurrence, the area under OCC was statistically significant (p<0.001) .The value of 2.494 for NLR was found to be a cut-off value which can be used in order to distinguish recurrence according to Youden index. According to this, patients with a higher NLR value than 2.494 had higher rates of PSA recurrence with 89.7% sensitivity and 92.6% specificity. Conclusions: There are certain parameters used in order to predict recurrence with today's literature data.We think that because NLR is easy to use in clinics and inexpensive, and also has high sensitivity and specificity values, it has the potential to be one of the parameters used in order to predict biochemical recurrence in future.

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Section: Discussionmentioning

confidence: 91%

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Gazel¹,

Taştemur²,

Açıkgöz³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…First, cancer cells release myeloid growth factors (e.g., granulocyte colony-stimulating factor) resulting in production of neutrophils (Lord et al, 1989). Second, circulating neutrophils secrete various cytokines, including vascular DOI:http://dx.doi.org/10.7314/APJCP.2014.15.2.945 Neutrophils and Inflammation Predict Survival in Patients with Advanced Gastric Cancer endothelial growth factor (VEGF), tumor necrosis factor-α, and interleukins, which contribute to the progression of cancer (Ulich et al, 1987;Mahmoud et al, 2002;Kusumanto et al, 2003;Fondevila et al, 2004). Further, we found that elevated neutrophil count was associated with poor pathological differentiation, more advanced stage, more metastatic sites, peritoneal metastasis and higher GPS, all of which are associated with poor prognosis, suggesting that higher neutrophil count was probably related to great tumor burden.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR , GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

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“…Therefore, in the present research, the absolute neutrophil count was used as a predictor. Furthermore, studies have shown that neutrophils are associated with the systemic release of growth factors and proteolytic enzymes, such as VEGF and matrix metalloproteinase-9, which promote tumor invasion, metastasis and angiogenesis (32,33).…”

Section: Univariate Analysismentioning

confidence: 99%

Peripheral blood neutrophil count as a prognostic factor for patients with hepatocellular carcinoma treated with sorafenib

Yuan

Liang

et al. 2017

Molecular and Clinical Oncology

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Abstract. Sorafenib is currently the only efficient molecular targeted therapy for hepatocellular carcinoma (HCC), although its effect is relatively moderate and variable between individuals. The present study aimed to evaluate the significance of peripheral blood neutrophils in the prognosis of HCC patients treated with sorafenib. A total of 464 patients with HCC were treated with sorafenib at Zhongshan Hospital (Shanghai, China) between January 1st, 2008 and December 31st, 2012, among which 120 patients were enrolled in the study. The optimal cutoff point for low vs. high neutrophil count (3.65x10 9 ) was obtained from a receiver operating characteristic curve. Overall survival (OS) was compared between the patients with low and high peripheral neutrophil counts. Univariate and multivariate analyses were used to explore the prognostic factors associated with OS in the patients treated with sorafenib. A nomogram model was also performed to predict the OS times of these patients. The median OS time was 9.0 months (95% confidence interval, 5.9-12.1 months) in the whole group of patients, with 1-, 2-and 3-year OS rates of 36, 24 and 16%, respectively. Using a cutoff level of 3.65x10 9 neutrophils/l, the median OS time was longer in the group of patients with a low peripheral neutrophil count than in those with a high peripheral neutrophil count (11.5 vs. 5.0 months, respectively; P<0.001). The multivariate analysis showed that peripheral neutrophil count, α-fetoprotein level and tumor size were independent prognostic factors for OS. In addition, using the nomogram model for the prediction of OS, the Harrell's c-index was 0.79. Therefore, it was concluded that a lower peripheral blood neutrophil count was associated with a better prognosis following treatment with sorafenib therapy.

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Platelets and Granulocytes, in Particular the Neutrophils, Form Important Compartments for Circulating Vascular Endothelial Growth Factor

Cited by 483 publications

References 12 publications

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Peripheral blood neutrophil count as a prognostic factor for patients with hepatocellular carcinoma treated with sorafenib

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