Platelets, a Key Cell in Inflammation and Atherosclerosis Progression

Huilcaman, Ricardo; Venturini, Whitney; Fuenzalida, Lucia; Cayo, Ángel; Segovia, Raul; Valenzuela, Claudio; Brown, Nelson E.; Moore‐Carrasco, Rodrigo

doi:10.3390/cells11061014

Cited by 33 publications

(22 citation statements)

References 90 publications

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“…This index has been used in the field of oncology, but in the last few years, it has become a promising biomarker in other conditions, particularly in cardiovascular disease [ 20 , 21 , 22 ]. In the atherosclerotic process, the inflammatory response and oxidative stress also play important roles, and the activation of platelets by inflammatory triggers may be a critical component of vascular damage [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Marco

Urbano

Filippello

et al. 2022

JCM

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Alterations of glucose homeostasis are associated with subclinical vascular damage; however, the role of platelet reactivity in this process has not been fully investigated. In this cross-sectional study, we evaluated the correlation between markers of platelet reactivity and inflammation and markers of vascular disease in subjects with prediabetes. Markers of platelet reactivity such as 11-dehydro-thromboxane B2 urinary levels (11-dh-TXB2) and mean platelet volume (MPV) and inflammatory indexes such as platelet-to-lymphocyte ratio (PLR) were evaluated in subjects with prediabetes (n = 48), new-onset type 2 diabetes (NODM, n = 60) and controls (n = 62). Furthermore, we assessed the cardiovascular risk profile of the study population with arterial stiffness and quality intima–media thickness (qIMT). Subjects with prediabetes and NODM exhibited higher 11-dh-TXB2 urinary levels and MPV and a proinflammatory profile with an increased PLR, high-sensitivity C-reactive protein, ferritin and fibrinogen. Furthermore, after multiple regression analyses, we found that urinary 11-dh-TXB2 was one of the major determinants of IMT and arterial stiffness parameters. In conclusion, subjects with prediabetes exhibit increased platelet reactivity as well as a proinflammatory profile. Furthermore, this condition is associated with early markers of cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Marco

Urbano

Filippello

et al. 2022

JCM

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“…Studies have suggested that changes of platelet size, density and other parameters in blood circulation have an important impact on the development and prognosis of ACS 20 . There is also evidence that platelets cross the endothelium and act as a direct mediator of plaque development 21 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Yan,

Wu,

et al. 2022

Preprint

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Colchicine has an obvious anti-inflammatory effect. The occurrence of acute coronary syndrome (ACS) is accompanied by a series of inflammatory reactions. We aimed to evaluate the efficacy and safety of colchicine in patients with ACS. Randomized controlled studies (RCTS) about the effects of colchicine on the treatment of patients with ACS were identified by searching databases including PubMed, EMBASE, Web of Science, and Cochrane Library. A meta-analysis was performed using RevMan5.3 statistical software. Eight RCTs with 6730 patients were included in the meta-analysis, involving 3362 patients in the colchicine group and 3368 patients in the control group. Compared with the control group, the major adverse cardiovascular events (MACE) [OR 0.69, 95% confidence interval (CI) 0.57–0.83], recurrence of ACS (OR 0.71, 95% CI 0.56-0.91), revascularization (OR 0.45, 95% CI 0.29-0.70), and stroke (OR 0.36, 95% CI 0.17-0.75) were reduced in the colchicine group, but there were no significant differences in cardiac death, all-cause mortality, or gastrointestinal symptoms. In conclusion, Colchicine can be used as a new effective and safe medicine for the treatment of ACS, which can effectively reduce the occurrence of MACE, cardiovascular and cerebrovascular ischemic events, and revascularization without increasing the adverse reactions. The results is expected to be further verified by increasing the clinical sample size in the future.

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“…However, under pathological conditions, platelets are prone to uncontrolled activation and aggregation, and may lead to vascular occlusion. Platelet activation can cause blood vessels to block and promote AS development (Huilcaman et al, 2022; Lindemann, Kramer, Seizer, & Gawaz, 2007). LA inhibits the activation of phospholipase Cγ2 (PLCγ2)–PKC, Akt and MAPK and subsequently attenuates calcium and glycoprotein IIbIIIa (GPIIbIIIa) activation and ATP release, p‐selectin secretion, and calcium, thereby blocking platelet aggregation and thrombus formation (Lien et al, 2017).…”

Section: Glycyrrhizae Radix Et Rhizomamentioning

confidence: 99%

Therapeutic potential of traditional Chinese medicine in atherosclerosis: A review

Liu

Zhu

Chen

et al. 2022

Phytotherapy Research

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Atherosclerosis is the onset of endothelial cell damage and is characterized by abnormal accumulation of fibrinogen and lipid in large and middle arteries. Recent researches indicate that traditional Chinese medicine including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Ginseng Radix et Rhizoma, Fructus Crataegi, Glycyrrhizae Radix et Rhizoma, Polygoni Multiflori Radix, Fructus Lycii, and Coptidis Rhizoma have therapeutic effects on atherosclerosis. Furthermore, the pharmacological roles of these kinds of traditional Chinese medicine in atherosclerosis refer to endothelial function influences, cell proliferation and migration, platelet aggregation, thrombus formation, oxidative stress, inflammation, angiogenesis, apoptosis, autophagy, lipid metabolism, and the gut microbiome. Traditional Chinese medicine may serve as potential and effective anti‐atherosclerosis drugs. However, a critical study has shown that Notoginseng Radix et Rhizoma may also have toxic effects including pustules, fever, and elevate circulating neutrophil count. Further high‐quality studies are still required to determine the clinical safety and efficacy of traditional Chinese medicine and its active ingredients.

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Platelets, a Key Cell in Inflammation and Atherosclerosis Progression

Cited by 33 publications

References 90 publications

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Efficacy and safety of colchicine in patients with acute coronary syndrome: A meta-analysis of randomized control trials

Therapeutic potential of traditional Chinese medicine in atherosclerosis: A review

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