Platelet Transfusion Medicine

Perrotta, Peter L.; Parsons, Jeremy; Rinder, Henry M.; Snyder, Edward L.

doi:10.1016/b978-0-12-387837-3.00062-6

Cited by 9 publications

(16 citation statements)

References 263 publications

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“…However, until today, this aspect has attracted only a little attention (5,15,228). It must be considered, that a certain amount of PL-EVs underlies changes within PSL and it is not obvious, whether and how the viability and activatability of platelets in stored PCs in vitro are affected by the vesiculation of platelets.…”

Section: Discussionmentioning

confidence: 99%

“…Agitation is carried out in bags with oxygen exchange in order to maintain the aerobic adenosine triphosphate (ATP) formation. Obviously, there are several factors which influence PSL such as temperature, storage duration, form and intensity of agitation, volume of suspending plasma, permeability of the membranes of a storage container and a leukodepletion technique (5). Exemplarily, storage carried out almost at physiological temperatures (37°C) improves the viability of platelets due to a decrease of a rapid ATP turnover and a lower metabolic activity of stored platelets (5, 6).…”

Section: Preparation Of Solutionsmentioning

confidence: 99%

“…Shape change causes the disappearance of the "swirling" phenomenon caused by the fact that shapechanged platelets are not able to refract light (5). The weaker "swirling" phenomenon correlates to a lower platelet increment in vivo which is measurable after transfusion (5,35). This happens because pH lower than 6.3 translates to diminished in vivo survival after transfusion (5).…”

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

“…The analysis of platelet activation during manufacturing by flow cytometry and evaluation of the p-selectin (CD62P) exposure at the platelet surface (36) is another useful measurement of PC-QC and it is applied as the most common measurement of platelet activation in PCs (5). In contrast to the physiological behavior of activated platelets, ex vivo p-selectin expression on the platelet surface upon activation by cold or pH below 6.2 is not reversible (37).…”

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

“…In general, the activation of platelets entails the occurrence of adverse effects during storage, but it is hardly evident that the rate of activation is associated with post-transfusion recovery (5). Several studies reported that p-selectin expression does not affect platelet clearance (38,39) and may not reflect platelet survival and function in vivo (5).…”

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

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Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

et al. 2015

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BACKGROUND Platelet‐derived extracellular vesicles (PL‐EVs) are present in plateletpheresis concentrates (PCs) and may influence the quality of PCs. The aim of the study was to analyze PC‐derived PL‐EVs and to correlate them with standard quality control (QC) variables of PCs and with donor‐specific laboratory variables. STUDY DESIGN AND METHODS PL‐EVs were analyzed by standard as well as advanced high‐sensitivity flow cytometry (FCM) and nanoparticle tracking analysis. A hematology analyzer was applied to the determination of platelet (PLT) count and immature PLT fraction (IPF). Functional capacity of PLTs (CD62P in response to thrombin receptor‐activating peptide 6 activation) was measured by FCM. All in vitro measurements were carried out on Day 0 and on Day 5. Altogether, a total of 42 PC samples, 15 irradiated on Day 0, were investigated. RESULTS Externalization of CD62P, as an indicator of intact PLT function, significantly decreased during in vitro PLT senescence and CD62P expression inversely correlated with increased PL‐EV levels. Interestingly, in fresh PCs a significant correlation was found between PL‐EVs and different hemapheresis instruments, duration of apheresis, and IPF count in peripheral blood of the donor before apheresis. In senescent PCs, the body mass index of donors inversely correlated with the PL‐EV counts. CONCLUSION Loss of PLT function in PCs was associated with increased PL‐EV levels. Shedding of PL‐EVs depends on shear stress influenced by different hemapheresis settings and diverse preanalytical conditions of donors. PL‐EV analysis may stimulate new quality and apheresis strategies for more vital PLTs for transfusion.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Solutionsmentioning

confidence: 99%

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

Section: Possibility Of Transfusion Reactions (Tr)mentioning

confidence: 99%

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Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

et al. 2015

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Blood Transfusion

Guillaumin¹,

Kofron²

2023

Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care

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Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

Yang

Tang

et al. 2022

ACS Appl. Bio Mater.

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Traditional Chinese herbal medicine (TCHM) is the naturally available pharmaceutical with millennia of evolution from ancient China, capable of a superior therapeutic index and minimized unwanted effects on the human body. This work presents a therapeutic microrobotic platform based on pollen typhae (PT), a typical type of TCHM, fabricated by coating porous PT microspheres with Fe 3 O 4 nanoparticles (PT robots) via electrostatic adsorption. The PT robots exhibit effective and controllable motion in various biological media upon external magnetic control and, meanwhile, preserve the inherent hemostasis property of PT. The blood clotting capacity of PT robots is attributed to their stimulation of the endogenous blood coagulation pathway and platelets with increased counts, which could be further improved by their effective magnetic propulsion. The remote magnetic control also allows the manipulation of PT robots in mice stomach, inducing enhanced binding and prolonged retention of PT robots in stomach mucosa. Moreover, PT robots upon magnetic control show an enhanced hemostatic effect in treating the mice bearing acute gastric bleeding compared with other passive groups. This work offers a facile and feasible route to integrate TCHM with manmade micromachines possessing the innate curative features of TCHM. Such a design expanded the versatility of microrobots and can be generalized to vast types of TCHM for broader biomedical applications.

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Platelet Transfusion Medicine

Cited by 9 publications

References 263 publications

Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

Blood Transfusion

Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

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