Platelet Transfusion: A Clinical Practice Guideline From the AABB

Kaufman, Richard M.; Djulbegoviĉ, Benjamin; Gernsheimer, Terry; Kleinman, Steven; Tinmouth, Alan; Capocelli, Kelley E.; Cipolle, Mark; Cohn, Claudia S.; Fung, Mark; Grossman, Brenda J.; Mintz, Paul D.; O’Malley, Barbara; Sesok‐Pizzini, Deborah; Shander, Aryeh; Stack, Gary; Webert, Kathryn E.; Weinstein, Robert A.; Welch, Babu G.; Whitman, Glenn J.R.; Wong, Edward C.C.; Tobian, Aaron A.R.

doi:10.7326/m14-1589

Cited by 754 publications

(668 citation statements)

References 67 publications

Supporting

Mentioning

628

Contrasting

Unclassified

Order By: Relevance

“…Single-donor platelets retrieved from apheresis and random donor pooled platelet concentrates have a shelf life of about 5 days, when stored at 22+/-2°C with similar efficacies in raising the post transfusion platelet counts [1].…”

Section: Discussionmentioning

confidence: 99%

“…Platelet count at 24hour 65,000 (50,000-1,00,000) 12,000 (9,(0)(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) A randomized trial consisting of 26 haematology-oncology patients found that the incidence of acquiring PLT refractoriness was lower amongst those who received ABO identical PLTs compared to those who received ABO mismatched PLTs [16].…”

Section: Discussionmentioning

confidence: 99%

“…Although according to some of the studies, there is no role for prophylactic platelet transfusion therapy in dengue patients, many clinicians transfuse platelets to correct thrombocytopaenia during the critical phase of recovery from dengue infections to avoid haemorrhagic complications [1][2][3]. Dengue virus-induced bone marrow suppression and an immune mechanism of thrombocytopaenia results in severe thrombocytopaenia in patients with Dengue Hemorrhagic Fever (DHF) [3].…”

Section: Discussionmentioning

confidence: 99%

“…A platelet unit refers to one aphaeresis platelet unit or a pool of 4 to 6 whole blood-derived platelet concentrates, containing 3 to 4 × 10 11 platelets [1]. In case of adults, six units of random donor pooled platelets can be transfused in 20-30 minutes.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, to prevent the lethal outcome, the dengue patients are often hospitalized and serial platelet counts are monitored. When the platelet count is severely low, prophylactic platelet transfusions are given to circumvent haemorrhagic manifestations [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effectiveness of Pooled Platelet Transfusion in Concordant and Discordant Groups among Dengue Patients

Bhat¹

2016

JCDR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of Pooled Platelet Transfusion in Concordant and Discordant Groups among Dengue Patients

Bhat¹

2016

JCDR

View full text Add to dashboard Cite

Trends in Red Blood Cell, Plasma, and Platelet Transfusions in the United States, 1993-2014

Goel

Chappidi

Patel

et al. 2018

JAMA

View full text Add to dashboard Cite

Blood transfusions are one of the most common hospital procedures. Randomized trials have demonstrated the safety of restrictive transfusion strategies. 1 Hospitals have subsequently implemented patient blood management programs to facilitate restrictive transfusion practices aimed to improve patient outcomes, reduce costs, and conserve blood. We are unaware of nationally representative studies evaluating temporal trends in red blood cell (RBC), plasma, and platelet transfusions while accounting for the influence of patient-level or hospitallevel characteristics.

show abstract

Association of Lumbar Puncture With Spinal Hematoma in Patients With and Without Coagulopathy

Bodilsen

Mariager

Vestergaard

et al. 2020

JAMA

View full text Add to dashboard Cite

IMPORTANCE Coagulopathy may deter physicians from performing a lumbar puncture.OBJECTIVE To determine the risk of spinal hematoma after lumbar puncture in patients with and without coagulopathy.DESIGN, SETTING, AND PARTICIPANTS Danish nationwide, population-based cohort study using medical registries to identify persons who underwent lumbar puncture and had cerebrospinal fluid analysis (January 1, 2008-December 31, 2018; followed up through October 30, 2019). Coagulopathy was defined as platelets lower than 150 × 10 9 /L, international normalized ratio (INR) greater than 1.4, or activated partial thromboplastin time (APTT) longer than 39 seconds.EXPOSURES Coagulopathy at the time of lumbar puncture.MAIN OUTCOMES AND MEASURES Thirty-day risk of spinal hematoma. Risks were provided as numbers and percentages with 95% CIs. Secondary analyses included risks of traumatic lumbar puncture (>300 × 10 6 erythrocytes/L after excluding patients diagnosed with subarachnoid hemorrhage). Adjusted hazard rate ratios (HRs) were computed using Cox regression models.RESULTS A total of 83 711 individual lumbar punctures were identified among 64 730 persons (51% female; median age, 43 years [interquartile range, 22-62 years]) at the time of the procedure. Thrombocytopenia was present in 7875 patients (9%), high INR levels in 1393 (2%), and prolonged APTT in 2604 (3%). Follow-up was complete for more than 99% of the study participants. Overall, spinal hematoma occurred within 30 days for 99 of 49 526 patients (0.20%; 95% CI, 0.16%-0.24%) without coagulopathy vs 24 of 10 371 patients (0.23%; 95% CI, 0.15%-0.34%) with coagulopathy. Independent risk factors for spinal hematoma were male sex (adjusted hazard ratio [HR], 1.72; 95% CI, 1.15-2.56), those aged 41 through 60 years (adjusted HR, 1.96; 95% CI, 1.01-3.81) and those aged 61 through 80 years (adjusted HR, 2.20; 95% CI, 1.12-4.33). Risks did not increase significantly according to overall severity of coagulopathy, in subgroup analyses of severity of coagulopathy by pediatric specialty or medical indication (infection, neurological condition, and hematological malignancy), nor by cumulative number of procedures. Traumatic lumbar punctures occurred more frequently among patients with INR levels of 1.5 to 2.0 (36.8%; 95% CI, 33.3%-40.4%), 2.1 to 2.5 (43.7%; 95% CI, 35.8%-51.8%), and 2.6 to 3.0 (41.9% 95% CI 30.5-53.9) vs those with normal INR (28.2%; 95% CI, 27.7%-28.75%). Traumatic spinal tap occurred more often in patients with an APTT of 40 to 60 seconds (26.3%; 95% CI, 24.2%-28.5%) vs those with normal APTT (21.3%; 95% CI, 20.6%-21.9%) yielding a risk difference of 5.1% (95% CI, 2.9%-7.2%). CONCLUSIONS AND RELEVANCEIn this Danish cohort study, risk of spinal hematoma following lumbar puncture was 0.20% among patients without coagulopathy and 0.23% among those with coagulopathy. Although these findings may inform decision-making about lumbar puncture by describing rates in this sample, the observed rates may reflect bias due to physicians selecting relatively low-risk patients for ...

show abstract

Platelet Transfusion: A Clinical Practice Guideline From the AABB

Abstract: The AABB cannot recommend for or against platelet transfusion for patients receiving antiplatelet therapy who have intracranial hemorrhage (traumatic or spontaneous). (Grade: uncertain recommendation; very-low-quality evidence).

Cited by 754 publications

References 67 publications

Effectiveness of Pooled Platelet Transfusion in Concordant and Discordant Groups among Dengue Patients

Effectiveness of Pooled Platelet Transfusion in Concordant and Discordant Groups among Dengue Patients

Trends in Red Blood Cell, Plasma, and Platelet Transfusions in the United States, 1993-2014

Association of Lumbar Puncture With Spinal Hematoma in Patients With and Without Coagulopathy

Contact Info

Product

Resources

About